The Signal podcast is now one year old. And in our first year, we've been able to cover so much truly fascinating science. It's also clear to us how much things have changed — and how much the understanding of science and medicine can evolve in single year.In this episode, we jump into our time machine to look back at human fecal matter transplants; drugs aimed at Duchenne muscular dystrophy and Alzheimer's; deaths in clinical trials; the cost of cures vs. drug prices; and the politics of medicine.This Signal podcast was produced by Jocelyn Gonzales. Illustration by Molly Ferguson for STAT.