Brian Cox and Robin Ince take to the stage at this year's Cheltenham Science Festival to discuss science mavericks. They are joined by comedian Marcus Brigstocke, medic and broadcaster Dr Kevin Fong, evolutionary biologist Aoife McLysaght and Nobel Laureate Professor Barry Marshall. Marshall, an Australian physician, famously experimented on himself to prove his theory that a bacterium was responsible for most peptic ulcers. He drank the bacterium he suspected was the cause, and as a result reversed decades of medical doctrine. He and the rest of the panel discuss the role of mavericks in science, how new theories get accepted and whether you have to go to such extreme lengths to truly push the frontiers of our scientific understanding.

Presenters: Robin Ince and Brian CoxProducer: Alexandra Feachem.