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Understanding The Vaginal Microbiome And The Impact On Women's Well-Being While Shaping The Future Women's Health With Pita Navarro

Understanding The Vaginal Microbiome And The Impact On Women's Well-Being While Shaping The Future Women's Health With Pita Navarro

Released Saturday, 20th January 2024
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Understanding The Vaginal Microbiome And The Impact On Women's Well-Being While Shaping The Future Women's Health With Pita Navarro

Understanding The Vaginal Microbiome And The Impact On Women's Well-Being While Shaping The Future Women's Health With Pita Navarro

Understanding The Vaginal Microbiome And The Impact On Women's Well-Being While Shaping The Future Women's Health With Pita Navarro

Understanding The Vaginal Microbiome And The Impact On Women's Well-Being While Shaping The Future Women's Health With Pita Navarro

Saturday, 20th January 2024
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We\u0027re we\u0027re set out to do to build a platform to really unlock the power of precision female health because I would say we we finally are starting to have precision health care, but really for middle age midsize white men. Um, and so we were really We\u0027re really excited to be able to build this database on thinking about what are those biomarkers that we\u0027ve been previously ignoring in our definitions of health and disease, and how can we use those to help women, um, feel healthier and feel better.\n\nClaudia: I mean, it\u0027s such an important mission as well. And I think so many people are just not even [00:05:00] aware. Talking about medical doctors included. I have a lot of friends and I was at a talk the other day about functional genomics and how, depending on how your genes are expressed, the hormones are the conductor of the symphony, right?\n\nAnd then your gene expression that as estrogen breaks down, it can be, you know, either, um, protective to the body or very toxic. And so women are just given birth control and be like, Oh, you know, you should just be on it or actually better yet. don\u0027t even have a period, just continue 365 days a year of overdosing hormones to yourself or even with HRT.\n\nIt\u0027s just kind of like, Oh, sure. Just, you know, try and see how you feel, et cetera. And without actually knowing what\u0027s going on. Um, so I, I think this is so, so, so important and I\u0027d love to, for you, maybe even to take a step back. It\u0027s like, what is your roadmap and why? Are you focusing first on the, um, vaginal microbiome and what is that, what are the next steps thereafter in terms of the biomarkers and things that you\u0027re looking at?\n\nPita Navarro: Yeah. You know, usually when we say we\u0027re starting with the vaginal microbiome, we get one of two [00:06:00] questions, either what is the vaginal microbiome, um, or why are you starting there? So I\u0027ll start with a quick one on one on the vaginal microbiome, um, and then I can dive into. Um, what we\u0027re doing in the microbiome and the road map ahead.\n\nUm, but if you think of the vagina, um, and its role in the female body, it\u0027s essentially the structural connection between the outside world and your most important reproductive organs. Um, and as for the microbiome, you know, most people know What a microbiome is in concept, at least the community of microbes that live on on different parts of your bodies includes bacteria, fungi, viruses.\n\nUm, we have one in our gut. We have one in our skin in our mouths. It turns out we also have one in the vagina, and these microbes in our vagina have really co evolved with us to do a lot more than just hang out there. It turns out they play a really interesting and protective role for us, um, which I like to refer as your local immune system.\n\nUm, so really the, the, the vaginal microbiome can be a critical determinant of, of health. [00:07:00] Um, uh, and then in terms of why we started there, I would say we talked to. a lot of women. We talked as well. Um, and it seems experiencing these condi you know, relief, they wo and statistically they\u0027re misdiagnosed than correct even if they get correctl of treatment than to get better.\n\nUm, and so this pointed out to a huge consumer problem that we can start with. And when we talked to doctors alike, they were equally frustrated. Why? I don\u0027t have, you know, more tests I can give. I don\u0027t have any novel treatments I can give. 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So one, they produce lactic acid, keeping the vaginal environment optimal, um, and aesthetic, um, making it really difficult for pathogens to survive and replicate in the vagina. Meaning that even if a pathogen gets into your vagina, they can\u0027t really make it upstream and cause havoc because it\u0027s an acidic environment.\n\nBut I always say anything fun, right? If you have sex with a new partner, or if you have your period, um, your hormones can start to fluctuate. Um, your vaginal pH can actually rise and some of those bad microbes can take over that protective bacteria. And that\u0027s when women start experiencing common infections like.\n\nbacterial vaginosis, UTIs, yeast infections, um, and it turns out that, you know, your local immune system is [00:09:00] responsible for actually a lot more than just these infections that women experience so often. This breakdown is also associated with much broader health outcomes like fertility or IVF failure, STI acquisition, cervical and so much more.\n\nSo it m sense that without a prot microbiome, you no longer preventing pathogens from so for us, it seemed like to start with. If we\u0027re a help women deal with their vaginitis, then we can also do research on, you know, how are these conditions related to cervical cancer progression or STI acquisition, fertility outcomes, preterm birth.\n\nUm, and so I think there was an amazing opportunity on the data side. Um, but there was also a very prevalent and frustrating problem that women are experiencing. And so I always like to say we\u0027re doing. patient centric research. So we started with the patient who\u0027s the most incentivized to change and and needs more help.[00:10:00] \n\nUm, and through that we are building the data sets that will allow us to do a lot more interesting research. \n\nClaudia: So exciting. And can you share a little bit more about how you are gathering the data? Like how does that process look like? Where are you in that process and how receptive are providers as well to this?\n\nUm, because they\u0027re obviously Obviously, if they\u0027re trained in a certain way, it\u0027s like, Oh, well, at medical school, I learned this way. Like, what are you guys doing? Right. So I\u0027d be curious to hear how that experience \n\nPita Navarro: is. Yeah. I mean, I\u0027ve been actually very pleasantly surprised. Um, I thought it was going to be, um, you know, an uphill battle battle with providers, but I would say, even from the last two years, you know, when we started off by saying, you know, you need to pay attention to the vaginal microbiome, these conditions are recurring.\n\nWomen are suffering from this. Um, I think providers We\u0027re already using a PCR test. You know, there\u0027s LabCorp and Quest already have PCR tests. So it wasn\u0027t that hard. Women are already going to the doctor for these conditions. They\u0027re already [00:11:00] doing a type of sequencing for test testing for the presence or absence of bacteria that we know are related to these infections.\n\nI think a lot of the education we were doing with providers are why are these tests coming back negative and the patient is still experiencing symptoms. And that\u0027s because We are only looking for the current tests, only look for four to five bacteria that could potentially be causing these symptoms.\n\nAnd if that comes out negative, the doctor says, you know, you don\u0027t have an infection when in reality there is hundreds of bacteria that could be causing this. And our tests are just limited and biased in what they\u0027re looking for. 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We do a lot of education on, on menopause. I think, you know, previously our. Women\u0027s education on menopause was hot flashes. You know, that\u0027s all your experience. And in reality, it\u0027s so multifactorial that, you know, I think now there\u0027s 36 symptoms [00:16:00] associated too. And so I think a lot of the work we do is, especially for perimenopause, where you\u0027re kind of like.\n\nDo I have an illness? Do I have a cold? What is happening to my body? It\u0027s this big area of, you know, am I in menopause? Am I not in menopause? Um, but we actually are very surprised. We have about 20 percent of our customers are in menopause, and that is because there is such a high, Um, relationship between estrogen and the vaginal microbiome.\n\nMm-Hmm. , um, you know, estrogen produces something called glycogen. And glycogen is actually what healthy lactobacilli bacteria use as an energy source. Mm-Hmm. . And so when you start seeing those estrogen levels decline, you start seeing women having their vaginal uh, symptoms. Whether that is dryness, that leads to irritation.\n\nor whether that is infection. Um, I will say most of the studies on the vaginal microbiome, um, have been done on women of reproductive age. Um, so it\u0027s hard to say, um, you know, this microbiome, what we think of a healthy, an optimal microbiome is [00:17:00] for women of reproductive age should be the same for menopause, but we do see, we know women in menopause are, are having, you know, symptoms, um, whether that is they\u0027ve never experienced vaginal symptoms and all of a sudden they have.\n\nrecurrent UTIs or they have BV or odor or discharge. Um, it\u0027s really correlated to estrogen. And so we like to work with menopause specialists on how do we approach this more holistically, right? Whether that is, um, addressing the dryness, if they have an infection, addressing the infection. Um, but I would say, for example, women are more likely in menopause because of the lack of estrogen have what we call dysbiosis or high diversity of bacteria.\n\nSome women have vaginal infection symptoms. Some women don\u0027t, they just, they just have the atrophy symptoms, the dryness. Um, and so it\u0027s really tricky. They really have to go with the right providers because if you just run a lab core test or a quest test, it can come back as positive for BV. But that might mean that that is what their microbiome looks like now, right?\n\nAnd a lot of the risks [00:18:00] with dysbiosis are associated with preterm birth, IVF outcomes, fertility outcomes. Um, and so I think there should be a lot more research on what is an optimal microbiome and menopause for asymptomatic women. Um, But we are doing a lot of research. We actually are. Um, the first pass we took at, can we use the vaginal microbiome to predict a condition, whether that was endometriosis or menopause or PCOS?\n\nUm, so really, can we find a microbial signature associated with it? Menopause was actually the strongest signal. We were able to predict whether someone was in menopause or not with 99 percent accuracy and that\u0027s age. I was just looking at the microbial composition of, of someone. Um, And so hopefully we can use the vaginal microbiome, especially for those women who are transitioning and they, they\u0027re not really sure what is happening.\n\nUm, then it\u0027s hard to have data on your body on what is happening. So we\u0027re, we\u0027re excited about the work we could potentially do in the menopause space. That\u0027s \n\nClaudia: super exciting. And because [00:19:00] again, like, why is there no predictor yet? Right. I\u0027m speaking to a few different people in the space, but like. 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And I\u0027m sure you guys speak with her too, um, to understand for fertility. So to come back to fertility point.\n\nWhat, how can you explain for people just thinking like, okay, how does my vaginal microbiome influence fertility? Is it not different components? Like what, what is the impact there? Um, and [00:20:00] what\u0027s the correlation and what could people should, should people be thinking about? \n\nPita Navarro: Yeah, of course. Um, if you go back to, you know, how I was explaining the vaginal microbiome as your local immune system, I would use that as a premise of how does it link to fertility?\n\nUm, I would say overall, there is evidence that lactobacilli dominance is beneficial for fertility. And this seems to be true for just about any population that is studied. you know, even in different geographical areas, um, there is the normal healthy population. Those that have recurrent implantation failure, miscarriage, unexplained infertility.\n\nUm, most, most studies point to lactobacilli dominance being beneficial for fertility. Um, so up until Last year, we really knew, you know, lactobacilli is associated with optimal fertility and pregnancy outcomes. Dysbiosis is associated with suboptimal outcomes. And actually, um, there has been some more, much more exciting evidence that suggests that microbial modulation actually improves fertility outcomes.\n\nAnd so, the [00:21:00] main goal is really to get a patient to a lactobacilli dominant state. Um, if that happens, then the pregnancy rates go up. And we also see that with assisted reproductive technologies. Um, although I will say specifically for IVF and other, um, uh, reproductive technologies, there\u0027s a few things to keep in mind as we dive into the research.\n\nOne is most studies are pretty small and on very specific populations. There\u0027s also a variation in sampling locations. Some look at the endometrial microbiome, some look at the vaginal microbiome. Um, And I always like to remind people, you know, the fertility journey is complicated and there\u0027s a lot of different patient populations to potentially focus on.\n\nBut there was actually a really interesting meta analysis done where they looked at 17 studies. I think it included like 3500 patients and it found that vaginal dysbiosis and IVF couples was associated with both early pregnancy loss and a reduction in clinical pregnancy rates. Um, and so Really going back to the, you know, you want [00:22:00] to be in a state of lactobacilli dominance because you want to have that local immune system.\n\nUm, and, and really, we\u0027ve never really had a way of testing, right? Or a lot of doctors are starting to test for, you know, vaginal infections before doing, um, IVF, but I would say, um, My, my favorite researcher in this space, her name is Inmaculada Moreno. She\u0027s based, um, out of the Carlos Simón Institute in Spain.\n\nShe\u0027s doing fascinating research on, um, on the microbiome\u0027s role in, um, fertility outcomes in IVF. \n\nClaudia: That\u0027s so exciting. And would you say, okay, so you go from testing, right? So what are solutions? What are things that people can be doing? And also. What are conversations people should be having with their care provider, right?\n\nTheir gynecologist, um, or obstetrician potentially. Um, what should people be aware of, would you say? \n\nPita Navarro: Yeah, of course. 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I don\u0027t think they would go to the doctor\u0027s office and get education on their vaginal microbiome.\n\nUm, there are some doctors that are very advanced and very, um, comprehensive that potentially do, um, endometrial microbiome, um, biopsies, which are helpful. Um, But I would say with thinking about how [00:24:00] can I be healthier, your vaginal microbiome should definitely be a part of that conversation. Um, and then I say, when you go to a doctor for IVF, for example, you have now tried for six to 12 months, you\u0027re not able to get pregnant.\n\nYou\u0027re going to the doctor, they\u0027re running a lot of different analysis. Um, you know, seeing if there\u0027s any, um, anything in your tubes that\u0027s abnormal, looking at any hypothalamic Pituitary failure, dysfunction of your ovaries. That that is also the right time to do it. Um, and usually those tests, they all come back.\n\nIf they all come back negative, the patient gets put into this black box of you have unexplained infertility, right? And what I am hoping is that we can do enough research to have that 30 percent be a lot less and us being able to point to actually it\u0027s your microbiome and we that\u0027s a great that\u0027s great news because we can we know how to modulate it or we know how to or we can start gathering the data on how to actually transition your microbiome to a lactobacilli dominated state.\n\nUm, and so I think that is [00:25:00] also when we should start testing, especially that black box. It can be so frustrating for women, right? Um, and it can feel like such a biological failure when there is really, we\u0027re not doing much for these women. We\u0027re just kind of leaving them as unexplained. And I think that is a misuse of the term unexplained.\n\nI think it\u0027s just, we haven\u0027t really looked into it. Um, and last year there was a really interesting study done out of Japan. It was the first interventional study looking for people who had experienced recurrent implantation failure. They would look at their microbiomes. And for those that had dysbiosis, they would.\n\nput them through antibiotics and probiotics, so they would modulate the microbiome. And those that were able to modulate the microbiome actually had the same fertility outcomes as those who started out in a lactobacilli state. Um, and so that I think will prompt fascinated research and hopefully a lot of hope for women, most importantly, that get put into this unexplained infertility bucket.\n\nClaudia: That\u0027s beautiful. Yeah. And I know I have friends who\u0027ve gone through this unexplained [00:26:00] infertility and later they\u0027ve had better outcomes as well, but it\u0027s so painful because you see kids everywhere, right? 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Um, that doctors actually really recommend. Um, and I think in the US, you know, there is, there\u0027s a lot of researchers that have these novels going selections that are currently undergoing clinical trials, but what\u0027s available over the counter to women, um, there are, I would say the most well researched strains that are in most of the products you find over the counter.\n\nUm, there\u0027s also a lot of doctors that recommend, um, They\u0027d get the compounding pharmacies to actually create vaginal suppositories with lactobacilli strains, um, to help with that. Um, and I, I\u0027m not sure if actually the probiotics that were used in the study in Japan were, are available over the counter to most women.\n\nUm, But I would say there, there is a lot of probiotics out there with minimal [00:28:00] research. Um, so it\u0027s hard to help women decipher, you know, what is your money, what\u0027s not worth your money. A lot of the times women are already lactobacilli dominant and the education we do is, you know, you don\u0027t necessarily need to take all of these things.\n\nActually, you\u0027re, you are, you know, your microbiome is in a good place right now. Um, but I would say that the thing I would really recommend is looking at the ingredient list and seeing if there is any. additional ingredients that shouldn\u0027t be in there. Um, and if they\u0027re able to find any research online on the specific strains mentioned and what they\u0027ve been researched for.\n\nA lot of the times they\u0027re researched more for overall health or gut health. Um, but I would say it\u0027s important to have vaginal specific strains, whether that is Crispatis or, um, Jansani, um, Kiseri in your probiotic. You guys need to \n\nClaudia: invent \n\nPita Navarro: this. I know we\u0027re working on it. \n\nClaudia: What are some of the, um, roadmap items that you guys are working on that you\u0027re most [00:29:00] excited about over the next few years?\n\nPita Navarro: Yeah. Um, well, there is so much work to be done. I think what it excites. me and my team about the spaces that there is really, um, not a lot done yet. We do stand on the shoulders of amazing researchers who have gotten us here. Um, and so it\u0027s really one, um, working with all of these researchers in the academic centers on, okay, we now have the largest data set on the vaginal microbiome and the metadata associated to it and start tapping into the labs, you know, whether they\u0027re working it, um, on diabetes.\n\nwhether they\u0027re working on preterm birth, um, but also really running clinical trials, um, and better characterizing disease. I think in the beginning we started the company, we said, I want to predict preterm birth. I want to predict IVF. And what we have learned is we have to take so many steps back because we first need to understand the very basic conditions.\n\nLike we, we\u0027re, we don\u0027t really understand. Or I would say properly, um, what dysbiosis means for all ages, [00:30:00] for all races, um, for all conditions and demographics. And so we\u0027re going to really start out with better characterizing disease. And once we have that better characterization, then we can start linking it to all of the diseases that we.\n\nwhere the microbiome plays an important role. Um, I think we are really interested in definitely helping those with unexplained infertility and what can we find in the microbiome. Um, so we\u0027re definitely looking into the fertility space, um, over the next year. Um, and also just, um, using our data to advance, you know, our understanding of the vaginal microbiome and working with all the scientists and the community.\n\nClaudia: It\u0027s, it\u0027s so beautiful, so exciting. 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Like, would you be able to access that? But to even help, maybe I guess from of teenage years or something like that as well, to set them up for a positive start in life to then go into the twenties, thirties, et cetera. Um, do you think that there\u0027s scope for, for looking at younger age girls as well, just to ensure that they are in a healthy state going into their twenties?\n\nPita Navarro: Of course. I think, um, the very least we can do is start with education, right? Like nobody taught us about, like, I had never even heard of the vaginal microbiome up until a few years ago as a scientist in women\u0027s health, right? Like how, how had we never heard about it? And I think part of it stems from people\u0027s.\n\nUm, you know, even saying the word vagina is hard for people. And so I think just doing a lot of education, um, in the teenagers, um, and really helping them, um, be comfortable with, you know, how do I talk about my symptoms? 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And I think, um, even what, how we can start today is just education. \n\nClaudia: Um, so phenomenal. Thank you so much for the work that you\u0027re doing for [00:33:00] the women around the world.\n\nUm, it\u0027s just so, so important. And this absurdity of knowing so little about women and the female body, I mean, this. It, we really need to exponentially change this. So, um, thank you. I really applaud you as well. Pita, can you share what excites you most and more in general now about the future of health and longevity and wellbeing in the coming years and beyond?\n\nPita Navarro: Oh my gosh, I think we can be talking about this for hours. I think, you know, every day I\u0027m reminded of, you know, it\u0027s so depressing. We don\u0027t know anything about the female body, but I think in a way it\u0027s actually equal parts exciting. I think, um, we are, I think. finally getting a little bit of attention now and a lot more funding.\n\nI would say. 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And so I think we\u0027re now starting to see a lot more companies that are focusing on the research that are focusing on why are ovaries aging before any other organ in our body?\n\nHow can we create, um, models of disease to actually properly properly study, right? Because if we don\u0027t have models of disease, We can\u0027t properly study the disease. We can\u0027t create medications or drugs. Um, and we can\u0027t really understand what\u0027s going on in the female body. 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Go back to first principles, and we say, let\u0027s start with biology because we kind of skipped over the biology and we just started giving women medications that weren\u0027t invented for them. And so I\u0027m really excited about this change in mindset of wait a minute. We have to start with the research.\n\nLet\u0027s actually understand from a biological perspective, what is going on and through that, then start creating a new standard of care. But I\u0027m optimistic. I think we\u0027re getting a lot of excitement and I think we are screaming from the top of our lungs that we need to help women and we need to research their bodies a lot more.\n\nAnd I think, um, we have a unique opportunity, I would say, because as we think about, you know, AI and generative AI, and, and if we don\u0027t have training sets with female body and female biomarkers in them, then we can\u0027t even use. You know, these algorithms that are being [00:36:00] invented to diagnose cancer to diagnose other conditions because, you know, people who are who look like you and I, we\u0027re not in the training data sets.\n\nSo how can we actually play Abby play a pivotal role in thinking about, um, how do we include our data in? You know, AI predictive diagnostics. Um, and I think in terms of generative AI vaginal health will be completely left behind because there is no data to, you know, to, to generate information. And so I think, um, I\u0027m excited about the opportunity that Evie.\n\nWe\u0027ll play, um, making sure that we don\u0027t get even further left behind in the world of AI. Yes, \n\nClaudia: so important. And thank you for sharing that. Um, yeah. And I think that\u0027s a really interesting point around with the AI is right. It\u0027s training on data sets, but the data sets are.\n\nAnd how, what do you think, like, what\u0027s the solution to that? How do we help people to understand the importance of training data sets are trying to [00:37:00] get access to data that is specifically, um, for women, like, is it there, is it available, do you think, or do you think it\u0027s just completely not even available to, for the AI to be training on?\n\nPita Navarro: Yeah, I would say it\u0027s going to depend on each condition. Um, I think, um, you know, we\u0027re going to have to be, you know, Hopefully that the guidance on how you create these algorithms before actually using them to diagnose is going to be to report on the demographics of the data that was that was used, um, in order to train and I think, um, I think it\u0027ll just require a lot of, um, rethinking of, um, you know, how do we actually build fair algorithms that will properly diagnose women?\n\nAnd I think, um, for female specific conditions, there is still a lot of research to be done before we start even training models. So I think for the, for the conditions that AI is being applied to, whether that is. Heart disease or whether [00:38:00] that is, you know, all different types of conditions. For example, heart disease and lung cancer, number one killers of women.\n\nSo we can start thinking about if those are the number one killers of women, what is being developed in this space and how can we make sure women aren\u0027t being left behind? Um, because that\u0027s what happened right in the 1980s. That\u0027s when we started figuring out, wait a minute. Um, you know, In the 1980s, heart disease was the number one killer of women and men.\n\nAnd it was an amazing technological age of creating stints and creating statins and a lot of pills and so much innovation was done. And 20 years later, the rate of heart disease in women kept going up while in men, it started going down. And that is the first time when we looked back and we realized, wait a minute, when we were inventing all of these screening procedures, all these medications, women were never included.\n\nUm, and so that should be, I think, a good learning as we think about Generative AI and predictive AI, um, making sure that, um, we have a reporting system in place. Um, and we also have a checks and balance of how can we make sure we, we make it better [00:39:00] for specifically women diagnosed. 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You were just saying this is how effective it was, but we didn\u0027t know it was effective. You know, this strong in women and this in men. So now we\u0027re starting to get all of these reporting systems in place.\n\nIt\u0027s just a matter of making sure the doctors and the clinicians who are treating the patient understand the limitations of the tools that they\u0027re using. \n\nClaudia: Yeah. And I think for women to feel empowered to ask those questions to their healthcare providers and, you know, is this safe for women? I saw some statistic at the talk that I think 80 percent of adverse medical condition, um, conditions for medication isn\u0027t on women.\n\nAnd purely because the medication was tested on men and not on women as well. And, um, yeah, so it\u0027s really time to change here. And I mean, part, [00:40:00] part of my time here in the UK and they\u0027ve introduced, um, talk therapy for women of menopausal symptoms, which is like, you know, talking about it will help the physical symptoms be better.\n\nI mean, it\u0027s just like, how is this possible in this day and age? Um, so I think it\u0027s. allowing women, trust yourself, listen to your intuition. Like we\u0027re so much more wise, like we just have to touch into that. And like, if you feel like something is off or wrong, you know, get a medical opinion, get a second or third one as well.\n\nAnd just know that the medical system As with, you know, status quo, the way it is, is not focused and caring for the women as it should be, because we don\u0027t have the medical research around it as well. So feel empowered, ask questions, ask again, don\u0027t be told, Oh, it\u0027s just, you know, your symptoms are go on an SSRI or whatever it might be that you, if your symptoms.\n\nFeel like symptoms and they probably are real and you can get to the \n\nPita Navarro: bottom of it as well. Exactly. I always like to tell people, you know, women, when you go to the [00:41:00] doctor, ask if the medication that they\u0027re giving you was ever tested on women or what the efficacy was on women. And also ask what are the tests that they are deciding not to run and why, right?\n\nLike there is, because there is. So much that doctors are kind of on autopilot. I don\u0027t blame them. They have 15 minutes, but they\u0027re not thinking about how you can be different from one of their male patients. And as a patient, you are completely in the right to ask as many questions as, as you can.\n\nClaudia: Exactly. I mean, since my young age, my mother always sent us with like, make sure you have your 10 questions ready for the doctor. That\u0027s a great, always liked it. \n\nPita Navarro: Yeah. Some doctors, you know, like it\u0027s most doctors, I would say. Won\u0027t be delighted, but I think that they would be happy to educate the patient, or at least answer some questions.\n\nClaudia: Yeah, no, I mean, I\u0027ve had the, I\u0027ve had another example of my first obstetrician. I have two kids, right? But the first one, um, he, uh, honestly went on to, I would come with my questions and he\u0027s like, Oh no, don\u0027t believe what you hear from other people or what you read on the internet. [00:42:00] Always different. And I was like, but I still have questions that I would like answered.\n\nAnd then my, my then husband asked a question. He\u0027s like, you\u0027re not even pregnant. It\u0027s like, this is not good medical care. 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I would say our content team has done an amazing job at taking everything my team works on on the research side and [00:43:00] science side and translating that into information for our users. I would say there is There is a lot of amazing books, I would say, um, there is a book called sex matters that I highly recommend that kind of dives into how the bias in the medical system actually affects women.\n\nUm, that would be mine. If you were to read one book, it would be sex matters. Um, and, um, yeah, I think there is, there are amazing. Resources online, I would say. Um, they\u0027re also amazing communities, um, where women are being very open about their symptoms, whether that is on Reddit or different Facebook communities where women are educating other women, or at least making them feel like they\u0027re not suffering in silos.\n\nUm, but I highly recommend the sex matters book as my all time favorite book. Um, And, um, yeah, I think if you, if you don\u0027t find information on our website, um, feel free to, um, email us. Our science team is always reading every single paper that is [00:44:00] published every week. Um, and we are trying to make sense of, you know, is this something that our audience would want to learn about?\n\nUm, and so you can go to ask Abby. com and submit a question if, if you don\u0027t find the resource there. \n\nClaudia: Beautiful, Pita. And where can people follow what you\u0027re up to? And Evy\u0027s up to, um, what are social media handles or websites that you\u0027d like to send people \n\nPita Navarro: to? Yes. Um, the blog is, um, evy. com slash ask Evy.\n\nUm, we\u0027re on Instagram as Evy. We\u0027re also on TikTok, um, doing amazing videos. Um, and we\u0027re also on LinkedIn. Um, and. You can definitely follow my personal LinkedIn. Um, I like to post about the research I\u0027m reading, um, or via the blog posts. Um, but we\u0027re also available if anyone wants to learn, please feel free to reach out.\n\nClaudia: Beautiful. Thank you for being so inclusive. Peter, do you have a final ask or recommendation or any parting thoughts or [00:45:00] message for my audience today? \n\nPita Navarro: Oh, that\u0027s a great question. Um, I would just like to one for all the women who are out there listening to this that have had their own story where they feel dismissed or they lose hope, um, where they\u0027re suffering in silo with symptoms.\n\nI would just say, you\u0027re not alone. We are doing as much work as possible to, to help understand your bodies and help treat your conditions. Um, and I would also say, you know, just to repeat what we always said is you have the right. to seek a different doctor, um, until you find the right answer. Until you find an empathetic doctor, you have the right to ask questions.\n\nUm, you are the expert on your own body, right? 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The Longevity & Lifestyle Podcast

Claudia von Boeselager is here to empower you to live at your best and reach your highest potential by sharing groundbreaking strategies, tools, and practices for your longevity and lifestyle from the world’s pioneering experts. For more, visit: LLinsider.comWelcome to The Longevity & Lifestyle Podcast!Claudia is on a mission to help 1 billion people optimize their lives and reach their fullest potential so that they can make a positive impact in the world!Tune in to learn how to increase your healthspan, improve the quality of your life and lifestyle also around entrepreneurship, managing personal finances and investing, and much more. Topics include how to optimize your health in areas such as sleep, nutrition, cognition, metabolic health, reversing diabetes, intermittent fasting, biomarkers, gut health, hormones, the female biorhythm, skin, hair, biohacking tips, supplements, mastering your mindset, improve your relationships and overall happiness, meditation, how to perform better in business, optimize your daily routines, achieve peak performance, biohacking your age, and more.Claudia is a Peak Performance Coach and Serial Entrepreneur passionate about helping you thrive in all areas of your life & business! She knows what it’s like to feel close to burnout and not be at your best. Thanks to 10+ years of research, countless interviews with global pioneers, and hundreds of thousands spent, she continues to uncover how you, too, can achieve peak performance to live your life at its best - all while having lots of fun!So make sure to TUNE IN and start living the best version of yourself!

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