Rejuvenation biotech is a new industry forming around the theme of life extension technologies. This episode provides a broad look at the state of the industry, its most promising life extension technologies and their potential timelines.Life

Microbiome Labs: How Actionable Are They Today? In the Future?

Mar 20th, 2018

Microbiome testing can be confusing: many companies, different technologies and a lack of standards make it hard to get actionable insights from the data. Find out how technologies and labs differ and what information is actionable from today's

50: Machine Learning Applied to Functional Medicine – Christopher Kelly & Tommy Wood

Aug 25th, 2017

Looking at an example of Machine Learning applied to functional medicine with the goal of helping athletes optimize performance. The question - with the help of artificial intelligence, can a 7-minute questionnaire identify physiological weakne

49: How Carbohydrate Intolerance Works – Robb Wolf

Apr 30th, 2017

What is carbohydrate intolerance? Do each of us have a personal tolerance or intolerance of carbohydrates? Does this also vary by source of carbohydrate? Learn how evolutionary tools may explain appetite regulation and carbohydrate metabolism a

Eran Segal & Lihi Segal: Is Your Glucose Metabolism Unique to You?

Dec 26th, 2016

Is your glucose metabolism driven by your personal microbiome? Recent research reveals how the microbiome influences blood glucose, weight gain and weight loss. And how the new company, "Day Two", is using microbiome sequencing data to provide

47: Using Supplement Testing Results to Ensure Supplement Efficacy – Neil Thanedar

Sep 23rd, 2016

Recent investigations have shown supplements to not always contain what they say they do. Or at other times to have unwanted contaminants such as heavy metals. Learn to use 3rd party lab testing to select supplements that contain the active ing

Chris Masterjohn: Fat Soluble Micronutrients Optimization

Jul 23rd, 2016

Micronutrient status is a foundation of health, performance and chronic disease minimization. This episode looks at how to optimize fat soluble micronutrients status.In this episode we look at ensuring micronutrient status. Ensuring your body

Dominic D’Agostino: Leveraging Ketone Bodies for Health, Performance and Longevity

Jun 19th, 2016

Ketone bodies, whether gained from fasting, keto diets, MCTs or exogenous ketones have many potential applications with benefits ranging from performance, to health, to longevity and mitigating symptoms and risks of certain diseases.There is

44: N=1 Experiment: Using Ketosis to Fight a Brain Tumor

May 8th, 2016

Putting the body into ketosis and controlling blood glucose levels may prove to be effective therapy against certain cancers. This real case reveals one aggressive self-experimenter who used a combination of the ketogenic diet, fasting and othe

43: Learnings from Continuous Glucose Monitoring (and the Future of Blood Sugar Management Tech) – Tim Omer

Apr 26th, 2016

Most of us have non-optimal blood glucose regulation today.The impact? Reduced performance, and reduced longevity. We wrongly assume that it's only diabetics that are exposed to these issues. This episode explores using continuous glucose monit

42: 10 Day Water Fast Results (Self Experiment)

Mar 29th, 2016

Part 3 in our series of Fasting Self-Experiments. In this longer 10 day water fast I tracked results with a broad set of biomarkers (ketones, glucose, weight, hormones and cognitive performance panels).This is a long post - if that scares you

41: How to Quantify Cardiovascular Fitness – Marco Altini

Feb 25th, 2016

A look at how to accurately quantify your cardiovascular fitness in order to optimize endurance sports or your cardiovascular health. Is VO2Max the gold standard? Are the metrics in the current "fitness trackers" useful for this goal?In this e

40: Quantifying Heart Disease Risk and Reducing Plaques in Your Arteries

Jan 20th, 2016

Heart disease affects 50% of the U.S. population in their lifetime. Learn how to accurately quantify your personal heart disease status and risk, and if necessary, take clear actions to reduce that risk by eliminating plaque in the arteries.Th

39: Meditation Tech to Increase Focus and Self Awareness (Interaxon’s Muse) – Ariel Garten

Dec 24th, 2015

Meditation - ever more popular as studies pile up proving its benefits. However, how do you assure yourself that you gain the same benefits with your meditation practice? Muse Calm is a neurofeedback device that promises accurate feedback on th

38: Can Genetic Testing Give Us Precision Health? – Michael Nova

Dec 3rd, 2015

What is genetic testing able to do and not do with current services? We talk with one of the top genetic lab services to understand how technologies differ in accuracy and where it is working, where it is not yet ready and why.In this episo

37: How the Human Microbiome Impacts Health – Dr. Rob Knight

Nov 18th, 2015

What defines human microbiome health? The co-founder of American Gut Project discusses the differences we've found in the gut microbiome and how it influences our health. We look at tools and lifestyle choices that have been shown to change the

36: Quantifying Cancer and Reexamining Which Cancers May be Inhibited by Fasts – Gene Fine

Oct 27th, 2015

Water fasting or ketogenic therapies may be effective with some cancers, and not with others. Learn about the PET scan and how it can provide insights into whether a cancer is likely to be responsive or not to the water fast tactic we've covere

35: Heart Rate Variability Biofeedback as a Tool to Reduce Stress – Richard Gevirtz

Oct 10th, 2015

An in-depth look at using heart rate variability biofeedback with slow breathing to reduce stress, enhance athletic performance and provide therapeutic support for some chronic health issues.Heart rate variability biofeedback is being used pr

34: High Impact Endurance Upgrades – Ben Greenfield

Sep 23rd, 2015

A look at a collection of high impact endurance tools and tactics - and the top biomarkers to watch for optimization. Vetted by an endurance athlete with years of experiments and competitions behind him.Today's episode is about endurance trai

33: How to Know What Improves Your Mental Performance (in Only a Few Minutes per Day) – Yoni Donner

Sep 21st, 2015

We strive for the best mental performance but how do you know if your routines (sleep patterns, coffee habits, etc.) are helping or hurting? The Quantified Mind is a web-based project that allows you to quickly check your cognitive function in

32: Quantified Medicine: Working with a Quant-Friendly Physician and Where Self-Tracking Makes Medicine Better – Paul Abramson

Sep 20th, 2015

Can physicians improve health outcomes using new self-tracking tech with their patients? Or is the tech still too inaccurate or impractical? We take a hard look at the reality and potential with a physician testing quantified self practices in

31: Fast Mimicking Diet (Self Experiment)

Sep 19th, 2015

Is the Fast Mimicking Diet (FMD) an easier way to get the benefits from fasting? In this self experiment I tracked lean muscle mass gains, improved metabolism (ketones, glucose), strong regeneration signaling (IGF-1) and a couple of downsides.

30: Is Oxaloacetate the Next Big Brain & Anti-Aging Supplement? – Alan Cash

Sep 18th, 2015

Oxaloacetate is an important metabolic intermediate in the energy pathway of the mitochondria. Recent case studies support the use of oxaloacetate as a nutritional supplement to help regulate blood glucose levels, potentially support longevity

29: How to Repair Mitochondria with Lipid Replacement – Garth Nicolson PhD

Aug 15th, 2015

Mitochondria, the power plants of our body, get damaged through aging and other stressors. Lipid Replacement Therapy (LRT) is a tool being used to repair part of this damage to mitochondrial membranes, and can help people recover and optimize t

28: 5 Day Water Fast Results (Self Experiment)

Jul 19th, 2015

A walk-through of the 5-day water fast with the tracked results (ketones, glucose, weight) and the practical do's and don'ts to make the most of the experience.I'm not a fan of cancer. The only people I've lost in memory - my grandfather and o