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Little boys and girls, ladies and germs. This is Tim Ferriss.

4:29

Welcome to another episode of the Tim Ferriss show, where it is my job to interview world-class performers from all different disciplines to tease out the habits, routines influences, life lessons, and so on that you can apply to your own lives.

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My guest today is Andrew Huberman.

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That's H U B E R M a N.

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PhD. You can find him on Twitter and Instagram at Huberman lab.

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Andrew is a neuroscientist and tenured professor in the department of neurobiology at Stanford university school of medicine.

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He has made numerous important contributions to the field of brain development brain function and neuroplasticity.

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Andrew is a McKnight foundation and pew foundation, fellow and recipient of the 2017 cogen that's C O G a N award for his discoveries in the study of vision work from the human laboratory at Stanford.

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Medicine has been consistently published in top journals, including nature science and cell.

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Andrew is the host of the Huberman lab podcast, which he launched in January of this year.

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The show aims to help viewers and listeners improve their health with science and science-based tools, new episodes air every Monday on YouTube and all podcast platforms.

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As mentioned, you can find him on Instagram and Twitter at Huberman lab.

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You can find him on the [email protected].

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Andrew,

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many

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people

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have

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been

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to

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for

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five

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or

5:39

six

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years. And finally, here we are welcome to the show.

5:48

Oh, thanks so much for having me here.

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Yes. We've crossed paths near misses for a long time, and it's great to finally sit down and chat.

5:55

I thought I would start right in your wheelhouse and use a headline to introduce the subject of vision scientific American interview do not long ago.

6:06

And they titled the piece quote, vision and breathing, maybe the secrets to surviving 2020 and quote.

6:12

So breathing, I think for a lot of folks might seem self-evident stop that you have a lot of problems on your hands, or if you do it incorrectly, we can, we can certainly dive into that later on vision.

6:23

I think we'll jump out is perhaps odd to a lot of folks.

6:27

Why vision?

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Why is vision perhaps a secret or a key to surviving 2020 or any year for that matter?

6:36

Yeah, so the vision and our visual system is perhaps the strongest lever by which we can shift our state of mind and body.

6:45

And that might at first come as a surprise because we think of vision as this thing that we have to see colors and motion and recognize faces, et cetera.

6:56

But the two little goodies in the front of our skull, our eyes are actually part of our central nervous system.

7:03

So a lot of people don't realize this, but your neural retina, the little light sensing piece of the eyes in the back of the eye, kind of lines, it like a pie crust, or actually two pieces of your brain that were deliberately squeezed out during early development.

7:19

So they're the only two pieces of your brain that are outside the cranial vault, as we say, and those little pieces of brain have an enormous impact on the state of the rest of your brain.

7:30

So it's fair to say that what you see and how you view the world literally has an incredible impact on your state of mind, respiration breathing also on your state of mind and body.

7:43

But the reason is the following our visual system is not just for seeing objects, shapes and colors, et cetera.

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Our eyes have to function so much in the same way that our ears are responsible for hearing, but also there's a balance mechanism in there.

7:59

Our eyes are responsible for detecting shapes and colors, et cetera, but also for telling the rest of the brain, whether or not to be more alert or more relaxed and the most fundamental way that our eyes do that is communicating time of day, the presence or absence of sunlight to our central circadian clock.

8:17

And then the central circadian clock, which is really just an aggregation of neurons communicates to the rest of the brain and body.

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Whether or not for instance, metabolism should be higher.

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Metabolisms should be low, whether or not we should feel like moving or feel like lying down and not moving at all.

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But there are a number of ways in which the visual system works on fast time scales to adjust our inner state.

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And one of the most simple ways that it does that is one that normally happens when we're stressed or relaxed, but we don't recognize it.

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So for instance, if we are very relaxed, our pupils change or the shape of our lens changes such that we actually have dilated vision, We

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see the entire environment we're in so-called panoramic vision when we are stressed or we are excited about something.

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The pupils dilate the shape of our lens changes.

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Literally the optics of our eye changes and the information about the outside world that's delivered to our, the rest of our brain and body changes the aperture of our experience, our entire experience shrinks.

9:18

We get so-called soda straw view of the world.

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We're looking through soda straws, essentially when we are alert or stressed and we've experienced this, but we don't normally notice it happening so much, like breathing our experience of life, whether or not we're alert or stressed, excited, or calm changes our patterns of breathing.

9:38

We're all accustomed to that. You know, our breathing speeding up, we're holding our breath in anticipation, but as well, our interstate drives changes in our visual system, the aperture of whether or not we see the big picture or we have a very contracted view of the world, but both of those things, breathing and vision also run in reverse.

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Meaning if we change our pattern of breathing, we change our interstate.

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If our state changes our breathing changes.

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So it's reciprocal, it's, bi-directional likewise with vision when we're excited or stressed, the aperture of our visual window shrinks, we get that soda straw view of the world when we are relaxed, the aperture of our vision expands, but as well, it runs in both directions.

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If we expand our view of the world, literally force our, our visual field or just, it's very easy.

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Actually, you can do it no matter where you are right now.

10:29

If you just try and expand your visual field, not by looking around or moving your head or eyes, but by trying to see yourself in the environment that you're in.

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So you literally dilate your view. So you could see the ceiling and the floor and the walls if you're inside, or if you're outdoor seeing as big an aperture of your visual field or your visual environment as possible.

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So you're directing your attention to, even though you might remain looking straight ahead, you're just directing your attention to as wide a peripheral view, horizontally and vertically as possible.

10:57

Is that what you mean? That's right. Exactly.

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So essentially, if you keep your head and eyes mostly stationary, you don't have to be rigid about rock steady, but if you look forward and you expand your field of view, so you kind of relax your eyes so that you can see as much of your environment around you as possible to the point where you can see yourself in that environment.

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What you do is you are turning off the attentional and believe it or not the stress mechanisms that drive your internal state towards stress.

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This is why when you go to a, a Vista or you view a horizon, it's very relaxing because you naturally go into panoramic vision.

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When you are indoors, you're looking at your phone, you're looking at a computer or a camera or something of that sort, or you're talking to somebody or an intense conversation.

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You may not notice it, but your entire visual field shrinks to a much smaller aperture.

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And that drives an increase in alertness and internal state.

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And we sometimes call that stress.

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If it's a negative experience, if it's a positive experience, we might call that love or obsession or fascination.

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But the important thing to realize is that both vision and breathing have a profound and very rapid effect on our internal state of mind and body.

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And it runs in both directions.

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Our internal state that could be triggered by a text message or hearing something that somebody says drives changes in our breathing and our vision, but our breathing and our vision can also drive changes in our internal state.

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And so that article in scientific American was a discussion about how we can leverage the visual system and the respiration, the breathing system in order to take control over our internal state, because it's not just that 2020 was stressful, it's that our internal state determines everything.

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It doesn't just determine if we feel like we're having a hard time falling asleep or we're having a hard time focusing, for instance, it also determines how we batch time, how we analyze where we are in the world in terms of our lifespan.

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A good example of this would be when we are very stressed, we find slice time.

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This is why when people are in a car accident or something, they might report that things were in slow motion.

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They're actually your frame rate increases.

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Whereas when you're very relaxed, your frame rate slows down.

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And when we are relaxed, we get so-called perspective.

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We are able to say, well, this too shall pass, or I can place this stressful event in a context.

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So one thing that's just fundamental to our nervous system works is that we are constantly placing our experience, both our immediate and past experience, as well as our anticipation of the future into some sort of larger context and our visual system, literally how we are viewing the world at that moment, dictates how we create perspective in terms of states of mind.

13:43

It sounds a little bit abstract, but it's actually, it boils right down to optics of the eye and very concrete things like how you move your eyes and how you view the world.

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This is super fascinating to me because I've thought a lot about breathing and how on one hand breathing is a function of the autonomous nervous systems.

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When you're asleep, you don't have to consciously inhale and exhale, but simultaneously it's this almost API into your autonomous nervous system, because while you're awake, you can control and direct and modify your breathing for that directionality.

14:18

But I've never thought about it from the, from the visual perspective and just a quick bit of trivia that is out of left field.

14:27

But nonetheless came to me that people might find interesting is that the dilation or this hyper dilation of pupils is, I don't know how much it is associated with arousal or sexual arousal, but for those who have ever heard the word, Bella, Donna is a plant.

14:46

The reason it's called Bella Donna beautiful woman in Italian is that it used to be Turned

14:52

into a tincture. And it, it is a psychotropic and it is also very dangerous.

14:56

I don't recommend people consume it but many, many years ago, hundreds of years ago, women in certain parts of Europe would create a tincture and put it into their eyes to hyper dilate their pupils because it was thought to be very, very attractive, beautiful woman.

15:10

Could you speak to how one can think about using their visual apparatus or stimulating or not stimulating their eyes, their visual system for say sleep.

15:27

If one wants to optimize for sleep, what are some considerations?

15:31

And it could be that it could be other inputs, but I'd just be curious to know how this fits into sleep for you.

15:39

Personally. Our light viewing behavior has perhaps the strongest effect on our levels of alertness and our capacity to fall asleep and get a good night's sleep.

15:51

And this is because at the fundamental layer of our biology, every cell in our body needs information about time of day.

15:59

It's no coincidence that we have a collection of neurons over the roof of our mouth.

16:05

The so-called super cosmetic nucleus.

16:07

That's our central circadian clock.

16:08

It informs every cell in our body about time of day, but it is deep in our brain has no access to light.

16:15

So there are a collection of neurons in the eye, the so-called melanopsin ganglion cells, or sometimes called intrinsically sensitive photosensitive ganglion cells.

16:25

These are just neurons in the back of your eye.

16:26

Remembering of course, that the eye is actually part of the brain that's outside the skull.

16:31

And those neurons communicate to the central clock when it's daytime and when it's night.

16:38

So the simple behavior that I do believe everybody should adopt, including many blind people.

16:44

We've talked about why that is, is to view ideally sunlight for two to 10 minutes every morning upon waking.

16:52

So when you get up in the morning, you really want to get bright light into your eyes because it does two things.

16:59

First of all, it triggers the timed release of cortisol, a healthy level of cortisol into your system, which acts as a wake up signal and will promote wakefulness and the ability to focus throughout the day.

17:12

It also starts a timer for the onset of melatonin, this sleepy newness hormone, or the hormone of darkness, as they say, melatonin is inhibited by light.

17:23

So by viewing light, first thing in the day, you set in motion, these two timers, one for wakefulness that starts immediately.

17:30

And one for sleepiness that starts later.

17:32

The key thing here is that people are hearing a lot nowadays about avoiding blue light blue light is so terrible.

17:39

Well, it turns out that blue light is exactly the wavelength of light that triggers activation of these cells.

17:44

And that's exactly what you want early in the day.

17:46

So people generally will, well, Maybe

17:49

I should just look at my computer or my phone first thing in the day.

17:52

Well, it turns out that the cells are very hard to activate early in the day and very easy to activate at night.

18:00

So it's kind of like the biology is encouraging us if you will, to take on the right behaviors, which are to get outside.

18:06

Even if there's cloud cover, there's a lot more light energy, a lot more photons coming through cloud cover.

18:11

Then you're going to get off your phone or a computer.

18:14

And early in the day, two to 10 minutes outside without sunglasses is going to be really beneficial for a huge range of biological functions and brain state.

18:25

I've made a practice I'm in the middle of nowhere in the country right now of, of getting up and not necessarily doing a full workout, but just jumping rope for literally two to five minutes, two to 10 minutes outside facing the sun where the sun is rising.

18:41

And there's certainly an effect.

18:44

I mean, I am moving. So there's an effect on cortisol.

18:46

And as you noted, it's cortisol gets this ridiculously bad rap across the board.

18:51

And it's like, guys, if you don't have cortisol, you're dead.

18:53

If you like having storing glycogen and breaking it down into glucose and so on you, it's important to have some cortisol.

19:01

There's a tremendous for me, mood elevating effect of this exposure.

19:07

And I'm just, I really have never familiarized myself with the mechanism by which that would be the case.

19:14

And certainly if it's placebo, I'm happy to just take placebo.

19:17

But do you have any explanation for why that exposure can have such a mood elevating effect?

19:23

Yeah, it's definitely not placebo that morning light exposure is going to also trigger the activation of dopamine release dopamine being this essentially feel good.

19:32

Neuromodulator that the best way to conceptualize dopamine is that yes, it's part of the reward system, but it's really the molecule of motivation and positive anticipation.

19:40

That's really what it's about.

19:42

And I should mention that the cortisol is going to be released in a pulse once every 24 hours, no matter what that's coming as we call it an intrinsic rhythm, but you can time it by viewing light and or by getting exercise early in the day, there are actually data to just kind of emphasize what happens when you don't do this.

20:02

There are really nice data from my colleague, David Spiegel's lab.

20:05

He actually co-published this with the great Bob Spolsky few years ago, David's our associate chair of psychiatry at Stanford.

20:11

And they showed that if that cortisol pulse shows up later in the day, and especially if it's around eight or 9:00 PM, then it's associated with depression by shifting that cortisol pulse earlier in the day, you ameliorate some of the symptoms of depression and because of the dopamine release, you get this overall mood enhancement.

20:33

There are four things that really time our circadian biology and these mood mechanisms properly and align us for sleep.

20:40

And they, the most powerful timekeeper as they say, Zeit Gaber cause Germans discovered this mechanism initially.

20:46

So the Most powerful timekeeper top guard that's there it is.

20:51

I know you do it better than I would is light.

20:54

When you view light and light is the most powerful stimulus for your biology and central circadian clock, then it's exercise.

21:01

So it's your protocol of jumping rope facing the sun.

21:05

You're layering on timekeepers.

21:07

You're giving more signals to the central clock and the rest of your body about when to be active.

21:13

And you're also indirectly singling when you will want to be asleep later, then it's feeding.

21:18

Yeah, I know a lot of people fast through the early part of the day.

21:21

Now that's very fashionable and I do that as well, where you to eat early in the day, that can also help.

21:28

And then the other one is social cues.

21:31

So interacting with people early in the day, or with your dog early in the day, have a dog had lived alone with my dog.

21:38

So that's how I interact with the world socially.

21:41

But those things are, we're going to create wake up signals and your body will start to anticipate them.

21:46

And your brain will start to anticipate them such that if you miss it for a day, you're still gonna wake up and feel that alert in a signal early in the day.

21:53

So this is not something that you have to do every day, but ideally you do it every day because it's like setting a clock or watch properly.

22:00

And I should mention that for people that live in areas with very dense cloud cover, you can use light boxes and things of that sort.

22:07

But irrespective of that in the morning and during the day and any time you want to be alert, you want to flip on as many overhead lights as possible.

22:14

This is because these cells in the eye that trigger activation and alertness of the rest of the brain and nervous system reside in the lower portion of the eye.

22:22

They view the upper visual.

22:23

Now the inverse of all, this is also important as you approach the evening or nighttime, and you want to go to sleep.

22:31

That is a time to start avoiding bright lights of any color, not just blue light and if possible, to place whatever lights are present in your environment, lower in your visual field.

22:42

So this would be desk lamps. Most people don't have floor lighting, dim the lights.

22:46

If you want to wear blue lockers or do something of that sort, that's fine.

22:50

But I think people have taken the blue blocker thing a little too far by wearing them all day.

22:54

That's actually going to disrupt your circadian.

22:56

Yeah. Clocks. So in the evening, you really want to avoid bright light of any kind.

23:01

And again, it's an averaging. If you do this every week, once in a while, you go to the bathroom and all night, or you have an emergency and things are really bright for one night, it's not going to screw you up.

23:10

However, there was a paper published in the internal sell a few years ago by my good friend and colleague at the national institutes of mental health.

23:17

His name is He's the head of the chronobiology unit at the national institutes of mental health.

23:22

And what Samara's lab showed is that bright, light exposure of any wavelength between the hours of about 11:00 PM and 4:00 AM cause a serious disruption in the dopamine system, such that in subsequent days you have a disruption in a lowering of mood, difficulty in learning.

23:43

There's a of things that happen.

23:45

In other words, we get punished for light viewing at the wrong times of their circadian cycle, and we get rewarded for light viewing at the correct times of the circadian cycle.

23:54

Hmm. Let's talk about the latter portion of the day before I get to that though.

24:00

Just for my understanding.

24:02

If one say, wants to target, going to bed or more accurately feeling sleepy enough to go to bed easily with rapid onset at say 10:00 PM.

24:15

Is there a preferred time to get that exposure early in the day in the sense that if I'm doing my 10 minutes of jumping rope facing the sun, is it best to have it a certain distance temporarily from when I want to go to sleep?

24:32

Yes. It's about 14 to 16 hours prior to when you want to sleep as the ideal time to get that morning light exposure.

24:39

And if we want to get a little bit technical about this, we can and I'll do my best to make it clear because there's also a way that you can use this mechanism to shift your circadian clock, to avoid jet lag and shift work.

24:53

I'll just ask you, so what's your typical wake up time, not getting up in the middle of the night and using the restroom necessarily, and then going back to sleep, but when do you finally get, get up and get out of bed?

25:02

What, what time does is that typically I

25:06

would say when I'm living my best life and not, not being Marty from back to the future, it's usually seven o'clock let's just say, Okay.

25:16

So if seven o'clock is your average wake up time, then we can be pretty sure that two hours prior to your natural wake-up time is what's called your temperature minimum.

25:25

It's when your body temperature was lowest, that temperature minimum, and I should be clear.

25:31

We don't need to know your actual temperature.

25:32

No one needs to know their actual temperature minimum, but you can count on the fact that two hours before waking up your body temperature is close to or at its lowest point.

25:42

And to be clear, this would be if you are waking without an alarm clock, right, that would be if you following natural, right?

25:49

That's correct. So if you view light, I should mention that you have to do this light viewing behavior with your eyes.

25:56

And that might seem obvious, but some years ago there was a paper published in the journal science, which is one of the three apex journals science nature cell.

26:04

And it stated that light presented to the back of the knee of humans could shift their circadian clocks.

26:12

And that paper was retracted by the same authors that publish the study.

26:16

There was a technical flaw.

26:18

Humans have no extra ocular photo reception.

26:22

So we need to tell those cells of the body, what time of day it is essentially where we are in time by light viewing behavior with the eyes blind.

26:33

People do this a little bit differently. Some blind people actually still retain these so-called melanopsin cells, people without eyes at all, maybe from a burn victim or something.

26:42

They, they are going to use social cues and exercise and other things.

26:45

But most everybody on the planet does this through light viewing behavior.

26:48

So when I say get light, what I mean is get light in your eyes.

26:52

Obviously he never so bright that it's going to damage your eyes.

26:55

You'll know if I'd light, right?

26:56

Because you'll want to close your eyelids.

26:58

That's a simple rule of thumb.

27:00

But the key thing here is that if you view light in particular, bright light in the hour or two, before that temperature minimum.

27:11

So for you, Tim, that would be between, you know, around 3:00 AM, 4:00 AM.

27:16

It's going to have the quality of delaying your circadian clock.

27:21

What it'll effectively do is make you want to stay awake later and it will make you want to sleep in later the following nights.

27:30

However, if you view light in the hour or so immediately after that, so-called temperature minimum.

27:36

So this for you, this would be 6:00 AM or seven, 8:00 AM.

27:40

It's going to shift your clock the other direction.

27:43

You're going to want to go to bed a little bit earlier, and you're going to want to wake up a little bit earlier than that next night.

27:48

Now, if you hear this, you're probably thinking, well, my clock is always more or less in the same place.

27:54

How come it doesn't jump around? I wake up, I view light.

27:56

How come I'm not going to bed earlier and earlier every night and waking up earlier and earlier, the reason is there's a second time of day, which is in the evening as the sun sets where your circadian clock is also vulnerable again to these shifts.

28:09

And typically because most of us are viewing light in the late night during noon, all of us are naturally having our clock shifted so that we want to get up earlier and go to bed earlier the next night and morning.

28:20

But we're also delaying our clock a little bit in the afternoon.

28:24

Now we can make this all very simple.

28:26

The simple thing to do is within 30 minutes of waking up, get bright, light exposure in your eyes and not from a phone or from a screen because it won't be sufficiently bright, get it from sunlight.

28:36

And if you can't get it from sunlight, you can use one of these light pads.

28:40

I don't use one of these expensive wake up clocks or something like that.

28:44

I bought an led drawing pad.

28:46

It's like a trace table.

28:47

It's like the artists cheat mechanism.

28:49

It actually says on it. And I forget the company, but it says 930 locks.

28:53

You can find these very inexpensively online and that's going to work great.

28:57

I just said it at my desk in the morning.

28:58

If it's very overcast and I'll work now, it is important to get outside because even though your windows or the windshield of your car is optically clear, it filters out a lot of that blue light.

29:11

That's important for setting your circadian clock.

29:13

So two to 10 minutes of light viewing early in the day, and then you can do yourself a great favor as well.

29:19

By going in, outside in the evening or late afternoon as the sun is approaching this, what we call low solar angle, because that will also send another signal to the brain that it's evening.

29:33

So there's a morning stimulus and an evening stimulus.

29:36

This only takes a few minutes each day.

29:39

And what's key to is that the cells in the of your body, they're going to have all these rhythms of liver function and metabolic function.

29:46

Your brain is going to have its rhythms of alertness and anxiety and sleepiness providing multiple signals.

29:52

So for you exercise and light in the morning, and then in the afternoon, a little bit of light is going to tell your system in a redundant way, but in a powerful way, these are the times to be awake.

30:03

These are the times to be asleep. And then if you like, we can talk about evening behavior, but that temperature minimum is worth knowing because if ever you are traveling for instance to Europe, what you can do is in the two or three days before you can just set your alarm, wake up around your temperature minimum of maybe an hour before, turn on some bright lights in your home.

30:23

So you get bright light exposure and you will start to shift your clock forward.

30:27

That nine hour jump can be accomplished in about two days.

30:30

If you do this correctly.

30:30

And the reverse is also true.

30:33

You could shift your clock earlier, if you like.

30:35

And when you land in Europe, if we want to get down into the weeds, when you land in Europe, you have to be cognizant of what your clock is back home.

30:44

Remember your temperature minimum, it's much more important than where you are in your new environment.

30:49

That temperature minimum is an anchor point.

30:51

Remember light viewed in the hour or two before that temperature minimum will make you want to go to sleep later and wake up later light viewed.

30:58

After that temperature minimum will make you want to go to sleep earlier and wake up earlier.

31:04

Let's talk about something that is a perennial topic, and that is sleep aids specifically.

31:11

I'd love to get your opinion on various supplements or prescription medications for that matter that people might use.

31:19

There's a huge list of things that people could use on the prescription side.

31:23

Certainly you've got the Ambiens and the Tramadols.

31:25

And so on.

31:27

Then on the supplemental side, you've got melatonin very, very popular.

31:32

You have California poppy.

31:35

I mean, there's an infinitely long list of various supplements.

31:38

I would love to hear your thoughts on at least two of these one is melatonin because of its popularity.

31:46

And then the second is actually so PS for short and using it to blunt cortisol release after going to bed.

32:00

And I'd just be curious to know if you have any opinions on those or any others that you would advise against or advocate for or use personally.

32:11

Sure. So I'll say why I'm not a fan of melatonin.

32:13

When I was a graduate student, I worked on the melatonin system and the circadian system.

32:19

And one of the most powerful effects of melatonin is to suppress puberty.

32:23

The melatonin system is closely linked up with GABA, inhibitory neurons in the hypothalamus.

32:31

It effectively keeps puberty from happening.

32:33

So the melatonin rhythms of young children, pre-pubertal children are not as phasic, right?

32:40

They're pretty constant.

32:40

And that's one of the reasons they don't go into puberty.

32:45

There are many other reasons they don't go into puberty until a certain triggers are set, but melatonin has strong effects on the sex steroid hormones, the pathways related to estrogen and testosterone.

32:56

And I think it was the one experiment that I did where we took.

33:01

We were working on these little they're called Siberian hamsters, these little hamsters who in long days, because they are seasonally breeding animals in long days.

33:11

These Siberian hamsters have testicles.

33:13

Well that at least for Siberian, hamsters are pretty impressive size.

33:17

If however you want inject those animals with melatonin, or you put them into short days, so you increase the amount of darkness and you decrease the amount of light, remembering of course, that light inhibits melatonin, their testicles shrink to the size of a grain of rice.

33:32

So I don't know if this was my male ego or something, but I saw that experiment and I thought, wow, this is powerful stuff.

33:39

This melatonin stuff. And it turns out in females of the same species, they leave estrous, they stopped cycling.

33:46

They don't have menstrual cycles, they have estrous cycles and there are powerful effects of melatonin on the reproductive axis.

33:52

Now humans are not seasonal breeders and we have a more robust sex steroid hormone access than that, but especially for children, but also for adults.

34:01

It just seems to me that melatonin has a number of other effects that are worth considering enough affects that I tend to avoid it.

34:09

Now I should also say, I say that most of the concentrations of melatonin that are in supplements are 10 to 1000 times what the indogenous internal levels would naturally be.

34:19

So people taking melatonin are seeing dramatic effects, but you're taking super physiological levels of melatonin.

34:27

We all kind of balk when we hear about people taking, you know, a thousand milligrams of testosterone cypionate a week, which unfortunately certain, certain people do, but this is the equivalent of super dosing sleep hormones.

34:42

And these are hormones that have other issues and other roles I say in the body.

34:47

So that's why I veer away from melatonin.

34:49

Also, there are three things that I found to be much more beneficial that seemed to have very good safety margins.

34:57

Of course, everyone needs to check with their physician, but those three things are magnesium three and eight T H R E O N a T E or by glycinate, magnesium by glycinate magnesium three and eight and magnesium by glycinate are able to be tracked that's ported across the blood-brain barrier, more readily than other forms.

35:17

So magnesium, I know, you know, a lot about this topic, Tim, so correct me anywhere I might misspeak, but like for instance, naseum citrate is a great laxative.

35:25

He goes by another name too.

35:27

You can imagine what it might be that will remind you that it's a, it's a great laxative.

35:30

What, it's not great at inducing sleep.

35:33

Newseum three and eight are magnesium by glycinate.

35:35

So 200 to 400 milligrams, about 30 minutes before sleep is a powerful sleep aid.

35:41

People with heart issues might not want to take it or might want to check with their doctor, but I take a cocktail of magnesium three and eight, and then two other things.

35:50

One is very commonly known, which is T H E N I N E 200 to 400 milligrams of theonine can create a kind of a hypnotic state help you fall asleep.

36:00

Basically falling asleep requires turning off your thoughts.

36:02

And the only people that should really avoid theonine I think are people who suffer from sleep walking or night terrors, it can create very vivid dreams.

36:13

And then the third thing is apigenin API, G E N I N, which is a derivative of chem a mile, but it acts as a chloride channel agonist.

36:24

So it essentially helps shut down the forebrain by hyperpolarizing neurons and all this kind of stuff for the aficionados, if they want to know.

36:32

So that cocktail of 50 milligrams of apigenin 300 to 400 milligrams of magnesium threonate or by glycinate and 200 to 400 milligrams of theonine for me has been the best way to consistently fall asleep quickly and stay asleep most, if not the entire night, which for me is about seven, eight hours.

36:51

And of course I'm not a physician, I'm a scientist.

36:53

Everyone needs to figure out what's right for them.

36:55

But many, many people who I've recommended this to have told me that in combination with the morning light viewing that their sleep has been completely transformed.

37:06

They thought they were so-called insomniacs, but they actually were just having a hard time turning off their thoughts and probably their cortisol was drifting too late in the day.

37:15

Sit to that cortisol point. This is fascinating.

37:17

And I just find it endlessly interesting that different forms of magnesium can be so target specific with respect to different tissues in the body.

37:29

So, so fascinating with respect to cortisol and needless to say, I have used fascial serin before sleep to help blunt cortisol release, but I do cycle, I use it as needed really, if there's a lot of rumination or I've had a particularly stressful day, but do you have any thoughts on whether or not you would ever do that personally, or if you'd be too concerned about side effects or long-term side effects, I suppose that could be a larger issue if you're just never cycling off, but do you have any thoughts on using different compounds to blunt cortisol release, if you're over ruminating and wants to sort of minimize that in this case stress response while you're trying to sleep?

38:16

I have not tried PS.

38:18

I use ashwagandha from time to time, if I'm in a particularly long bout of stress.

38:23

One of the things that I think is relevant here is that we hear about stress, but as terrible, but of course short-term stress buffers, the immune system, it actually activates the spleen to release killer cells and things of that sort.

38:34

We Are more robust in fighting off infection in the short term from pulses and cortisol.

38:39

But I would say we can define long-term stress as if you are having sleep disruption or you're feeling like you're in that wired and tired mode.

38:50

We don't really have a technical name for this for more than two or three days.

38:55

You're starting to enter the realm of long-term stress.

38:58

And that's where buffering cortisol can really help.

39:01

And that's where I start to take some ashwagandha late in the day.

39:04

There's good evidence that can buffer cortisol.

39:06

I do cycle it. So I'm not going to take it every night or every day.

39:10

I would probably stop after a week or so.

39:12

And then just go back to my normal regimen, which doesn't include ashwagandha, but I always have some on hand.

39:17

I have to say that I certainly use an and enjoy the benefits of supplements, many of them, in fact, but the practice that for me, has really helped reduce stress and allowed me to fall asleep more easily and control my state of mind late in the evening is this practice that some people call yoga nidra, which literally means yoga sleep and that practice of taking 20 or 30 minutes a day.

39:44

And it doesn't have to be done every day and lying down and doing a sort of body scan.

39:49

It involves some long exhale breathing, which is very relaxing to the nervous system and really allowing the mind to enter one of these pseudo sleep states.

39:58

We know from work in my laboratory and work that I'm doing with David Spiegel's laboratory, as well as work from other labs that that state of shallow nap or shallow sleep done in waking allows the brain to, and the person to get better at turning off their thoughts and falling asleep in the evening.

40:16

So I use both behavioral tools and pharmacology, which of course is really what supplementation is.

40:23

I don't have any problem with buffering cortisol a little bit in the short term.

40:28

So doing that for a week or two, but I wouldn't suggest that people suppress their cortisol long-term unless there's a real clinical need to do that.

40:37

Long-term being longer than two weeks, Just

40:44

a quick, thanks to one of our sponsors. And we'll be right back to the show.

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42:26

You mentioned long exhales in the context of the yoga nidra practice.

42:30

Is it fair to refer to that yoga nidra practice is also non sleep deep rest or NSD are those separate phenomena?

42:41

Yeah, so yoga nidra is one of several what we call NSD non sleep, deep rest protocols.

42:46

Admittedly, I coined the term and SDR because scientists like acronyms almost as much as the military likes acronyms.

42:53

And I did it deliberately not to Rob the beautiful history and community that is yoga nidra and the yoga communities of anything, but rather because many people are averse to doing anything that has a name like yoga nidra.

43:09

And yet it's such a powerful tool.

43:11

It's a zero cost tool that has enormous effects on not just accessing sleep and calm, but enhancing rates of neuroplasticity.

43:19

Something that we could talk more about.

43:22

Also David Spiegel, again, our associate chair of psychiatry at Stanford and close collaborator and friend of mine is a world expert in clinical hypnosis.

43:29

We are part of a, just in, in full disclosure.

43:32

We both sit on the advisory board of a company called reverie, R E V E R i.com.

43:37

Reverie is a zero cost app on Android and apple that has short hypnosis protocols anywhere from 10 minutes to 15 minutes hypnosis and yoga nidra both fall under the umbrella of NSD, our non sleep deep rest.

43:54

And these are protocols that people can use to deliberately access states of deep rest for sake of, again, falling asleep, more easily, reducing stress, but also for enhancing rates of learning of neuroplasticity.

44:07

And because these are zero cost tools.

44:09

And because they're grounded in excellent peer reviewed research, I feel comfortable mentioning them.

44:14

And what you find is that if people who are not familiar with meditation or mindfulness, or maybe they're not from west LA or the bay area, if they hear yoga nidra, they think magic carpets and they think, and they hear hypnosis.

44:30

They think that somebody is going to control their brain.

44:32

And SDR is my attempt to create a more friendly language, which is because all of these things are really just the same thing.

44:40

They really involve two things. One, self-directing a state of calm.

44:43

That's something that we never learned how to do unless we have a need to do it.

44:48

We suffer some trauma. We have chronic stress.

44:49

We start taking a mindfulness class.

44:51

We self inducing, a state of calm through respiration and vision is the hallmark of yoga, nidra and hypnosis.

44:57

And frankly of all meditative practices, our thoughts follow our vision and breathing.

45:03

And I can explain why that is in a moment.

45:04

In addition, these NSGR type practices involve not just self-directing calm, but they also involve directing our focus to something.

45:15

We generally have a hard time falling asleep because we think we have to turn off our thoughts completely like a switch, but the transition to sleep involves allowing our thoughts to become fragmented.

45:26

And then we become relaxed.

45:28

And then the brain enters the state where space and time are very fluid and not under our conscious control.

45:33

And those are things that we can teach ourselves.

45:35

So yoga need your scripts are found all over YouTube.

45:39

There's some great apps out there.

45:40

The zero-cost ones that I use are any of the stuff by Kameni.

45:45

K a M I N I decide D E S a I, I like her voice very much.

45:52

Some people like my sister loves Liam Guillen's voice another zero cost yoga nidra tool, Liam Gillen, a double L G I L L E N.

46:00

You have to find a voice that you like.

46:02

The reverie app is David's voice.

46:04

He has a very hypnotic voice, and there are scripts in there for smoking cessation stress and anxiety sleep, et cetera.

46:13

These, I really want to emphasize in addition to being zero costs are very powerful tools.

46:18

If done regularly, there are two papers that were published in the last two years from cell reports and cell press journal, excellent journals showing that a 20 minute non sleep deep rest protocol after about of intense focus or intense attempt to learn anything, skill learning or cognitive learning accelerates plasticity by about 50%.

46:39

So you are learning faster, much faster, and retention of that information lasts much longer.

46:46

And that's because these are sleep like states.

46:48

And we know that neuroplasticity, the brain's ability to change in response to experience is triggered by high focus, by deliberate periods of very high focus, but the actual rewiring of neurons, the formation of new synopsis and the reordering of the circuitry that leads to that skill or that cognitive ability becoming reflexive that happens in states of deep rest and non sleep, deep rest and SDR, whether it's gnosis or yoga nidra, or a shallow nap of about 20, 30 minutes, those things will all accelerate learning.

47:23

Let's hop around just a little bit yoga nidra first on the NSD, our study that you and the Increase

47:29

in plasticity, which I'm assuming it was measured by retention, recall, et cetera, but perhaps it wasn't, if you could send afterwards a link to that study, I'll put it in the show notes for listeners who, who might be interested.

47:42

We've touched on breathing in a few different capacities.

47:45

I have term in front of me, that seems kind of self-explanatory, but I don't know what form it takes.

47:54

Physiological size contrasted with other breathing methods for stress reduction.

47:59

Could you define what that is?

48:04

Yeah. A few years ago, when my laboratory got interested in studying stress in humans, we asked ourselves, what are the patterns of breathing that allow for the most rapid reduction in stress levels?

48:15

And more importantly, what are the patterns of breathing that can be done in real time so that people can adjust their stress while they're still engaging in life?

48:24

Right? Breath, work classes running off to SLN for a weekend is a magical experience, but life demands pressing on you.

48:30

That's typically when you feel stressed. So it is still true that vacation, long meditation retreats and massages, or a nice drink, if you're drinking age still work, but they're slow and they take you offline.

48:41

The physiological side is a pattern of breathing that was actually discovered by physiologists in the thirties.

48:47

And that was essentially rediscovered by professor Jack Feldman at UCLA, a world expert in the neurobiology of respiration.

48:55

And by my colleague, mark Krasnow at Stanford who studies lung function.

48:59

The physiological side is a pattern of breathing that we all engage in in deep sleep.

49:06

When levels of carbon dioxide in our bloodstream get too high, we, or our dogs, you can see your dog do this.

49:13

We'll do a double inhale, followed by an extended exhale children or, or adults for that matter that are sobbing and lose their breath.

49:22

So to speak. We'll also do a double inhale exhale.

49:25

That's the spontaneous execution of what we call the physiological side.

49:28

The reason it works so well to relax us is because it offloads a lot of carbon dioxide all at once.

49:35

And the way it works is the following.

49:37

Our lungs are not just two big bags of air.

49:40

We have all these little millions of sacks of air that if we were to lay them out flat, they would be as big as about a tennis quarter.

49:47

So the volume of air, therefore, and the volume of carbon dioxide that we can offload is tremendously high, except that we get stressed as carbon dioxide builds up in our bloodstream and is kind of a double whammy, these little sacks deflate.

50:02

Now, when we do a double inhale, so I'll do this now twice through my nose, or you could do this, or you could do it through your mouth, but it works best for the nose it's inhale.

50:10

And

50:10

then

50:10

you

50:10

sneak

50:10

a

50:10

little

50:10

bit

50:10

more

50:10

air

50:10

in

50:10

at

50:10

the

50:10

very

50:10

end

50:10

when

50:10

you

50:10

do

50:10

that,

50:10

you

50:10

reinflate

50:10

those

50:10

little

50:10

sacks

50:10

and

50:10

when

50:10

you

50:10

exhale,

50:10

then

50:10

you

50:10

discard

50:10

all

50:10

the

50:10

carbon

50:10

oxide

50:10

at

50:24

once. So the simple way to describe this protocol is unless you are underwater, you do a double inhale, followed by an extended exhale, and you offload the maximum amount of carbon dioxide.

50:35

And we found in our laboratory and other laboratories have found that just one, two or three of those physiological size brings your level of stress down very, very fast.

50:48

And it's a tool that, you know, you can use any time.

50:51

I do hope that people will kind of watch other people or dogs as they start to relax or go down to sleep.

50:57

You'll see this pattern of breathing, but again, it can be consciously driven.

51:00

The other thing about breathing and the reason why exhales are so vital is the following.

51:06

I know there's a lot of interest nowadays in heart rate variability.

51:09

Well, most people don't realize this, but your breathing is actually driving heart rate variability.

51:16

So when you inhale this dome shape muscle beneath your lungs, your diaphragm actually moves down because the lungs expand.

51:23

It moves down. When you do that, you create more space in the thoracic cavity and you actually, the heart gets a little bigger.

51:31

It actually expands as a consequence, blood flows more slowly through that larger volume.

51:36

And the brain quickly sends a signal down to the heart to speed the heart up.

51:40

The short, simple version of this is inhales speed.

51:43

The heart up when you exhale, the opposite is true.

51:47

That dome shaped muscle, the diaphragm moves up the space in your thoracic cavity gets a little bit smaller.

51:53

The heart gets a little bit smaller.

51:55

Blood moves more quickly through that small volume.

51:58

And the brain sends a signal to the heart to slow the heart down.

52:01

Physicians know this as respiratory sinus arrhythmia, but this is the basis of what we call HRV heart rate variability.

52:09

And the simple way to remember this is anytime you emphasize exhales, in other words, making them longer than your inhales.

52:15

You are slowing the heart rate down.

52:18

You're calming your system. Anytime you emphasize inhales, you make them more vigorous or longer than your exhales.

52:24

You're speeding up your heart.

52:26

I'd like to come back to hypnosis for a second.

52:29

I've never been hypnotized nor maybe I have self hypnotized and just not realized that's what I was doing.

52:37

What characterizes hypnosis, or how would we define that?

52:41

And do the states induced by hypnosis have any shared characteristics with some of the states induced by any psychedelics?

52:53

So hypnosis is a state of calm and high focus.

52:57

So context is restricted.

53:00

It's like looking at something through a telephoto lens, you're eliminating the surround.

53:05

So it's a state of high focus, which normally, as we talked about earlier with the aperture of the visual system would be associated with a high degree of excitement or stress, but hypnosis is a unique state because you have a high degree of focus, but you're very relaxed.

53:20

And just to remind people that neuroplasticity is triggered by states of high focus, followed by periods of relaxation later in deep sleep or in non sleep, deep breasts in hypnosis.

53:33

It brings both those states together at the same time.

53:36

And this is one of the reasons it's effective in accelerating neuroplasticity.

53:40

I could probably do it right now to see if how hypnotizable you are.

53:44

There's actually a test, a clinical test called the Spiegel eye-roll test.

53:48

Spiegel's father was a hypnotist and a psychiatrist.

53:51

So these, I want to be clear. These are not staged hypnotists.

53:54

These are board-certified MDs and PhDs, who there's a lot of scientific research to support what we're about to talk about.

54:00

So typically when we get sleepy, when we're relaxed, our eyelids close and our eyes go down and the chin goes down, the induction to hypnosis, involves doing the opposite, looking up, which actually believe it or not creates a state of alertness.

54:15

And then having you close your eyes.

54:17

So it creates a kind of conflict in the cranial nerves that innervate the eye and eyelid muscles again, the eyes and your state of mind are so intricately wired back there in the brainstem.

54:27

So if you could look up toward the ceiling, Tim, with your eyes open, and then just while still maintaining upward gaze, if you could just slowly close your eyelids.

54:37

Oh

54:40

boy. You're really hypnotizable.

54:43

So what did you see? That was deeply uncomfortable.

54:45

Yeah, I know it's a, it's a little bit odd.

54:48

So, so for those of you listening or watching you, you sort of look up towards what, you know, sometimes in yoga communities or meditation communities, they call the third eye center.

54:55

You know, we don't actually have a third eye, but if we did, it would probably be someone decided it would be between our two eyes and our forehead.

55:01

So by looking up you're inducing alertness, and then you're creating this conflict where were I asked you to close your eyelids, which is what you do when you're in a state of sleepiness and what Spiegel, both Spiegel, senior and Spiegel junior have figured out is that it's a very good predictor of how hypnotizable people are.

55:21

You can look up the Spiegel eye-roll test.

55:23

And what I was looking for is let's say if somebody is not very hypnotizable, what'll happen is as they close their eyes, they'll have a hard time closing them slowly.

55:31

They'll just kind of snapshot and their eyes will roll forward.

55:34

In other words, I'll see their pupils again.

55:37

What happened when I saw you do this, is that your eyelids were closing very slowly.

55:41

And I saw the whites of your eyes. Your eyes were starting to roll back into your head.

55:45

So you would have a score of probably about a four, which is very hypnotizable.

55:49

I'm about a, for some people you'll just notice you say, look up and then slowly close your eyes and their eyes will just kind of snapshot and their eyes will roll forward right before it's snapshot.

55:57

So you can do this experiment of sorts on people that you know, and it predicts pretty well.

56:03

How quickly or easily you will go into hypnosis.

56:06

I should mention that no one will go into hypnosis if they don't want to, but if you're interested in exploring hypnosis with the reverie app or with a clinical hypnotist and your eyes roll back the way that yours did Tim, then your home For

56:18

a year, you're going to be long. Amazing.

56:21

Amazing. I could maybe I'll Speaking

56:23

in tongues too. It does have a good, good associated look with it.

56:27

How would you explain the utility of hypnosis?

56:31

And, and then I do want to hear if there are any sort of correlates to some of the known effects of psychedelics and that's a wide spectrum of class, so we could choose, we could choose a given compound, but what, what are the, what are the clinical applications?

56:50

Because in my hypnosis naive mind, I think smoking cessation, isn't it good for quitting smoking?

56:58

Isn't it good for really just these anecdotal reports that I've read at one point or another, but what's the sort of clinical, what are some of the clinical applications or practical applications of hypnosis?

57:11

Yeah. So for smoking cessation, if people do the practice about a 60 to 80% success rate, depending on the study, you look at, these were all blinded controlled studies in terms of anxiety relief.

57:22

Those are tremendously strong effects.

57:24

As many as 90% of people are going to feel significant improvement in anxiety for pain management, for chronic pain, there's a high degree of success.

57:33

So, you know, people will vary depending on how hypnotizable they are and how regular they are about the practice, but anywhere from a 50 to 75% of people will experience a significant reduction in chronic pain.

57:44

And if they are using pain meds, they tend to be able to take lower doses of pain medications in order to manage that pain.

57:52

So it's quite powerful now for trauma and things of that sort, it, it needs to be done with a clinical hope.

58:00

I would hope board certified MD clinical hypnotist, and there, the success rates are quite high as well.

58:06

And if you want more research about this inside the reverie app, there's a long list of resources.

58:10

You can also, I can send over a good review article that David's written in.

58:16

These are again, published in very fine quality peer review journals of the new England journal JAMA sort and things like that.

58:24

Great. In terms of similarity, the psychedelics, they are quite distinct actually.

58:30

So hypnosis being a state of high degree of focus and relaxation is a bit similar to some of the so-called psychedelic.

58:38

So MTMA assisted psychotherapy, which it appears thanks to the support and work of people like you and the maps group and the group at Hopkins in particular, Matthew Johnson.

58:49

And I realized there were other people in that mix, but it's it.

58:51

I have to just say as a, as a point, it's, it's really exciting to see what's happening and the enthusiasm about safe building, safe protocols that people can access after so many years of people having to do this kind of Renegade or in unregulated environments, MTMA creates an, a very atypical state.

59:10

It's a state of high dopamine release.

59:13

And typically dopamine is associated with a focus on things external to us, dopamine being a, a molecule Associated

59:21

with motivation and reward makes us want to do more of things that brought the dopamine, whether or not that's food, sex, online viewing of any kind, et cetera.

59:32

It's not always, It's

59:34

not all dad, but online viewing online, viewing whatever that, Because

59:39

the best way to describe the effects of dopamine are that there's a book actually quite good book called the molecule of more.

59:45

And that's a great way to describe it. I wish I had written that book.

59:47

I read the book and thought, I wish I'd written this book.

59:49

It's because I, I loved the neuromodulator systems and it is the molecule of more.

59:53

And actually anyone that thinks that dopamine is about pleasure, not motivation or seeking more consider this.

59:59

This is an anecdote I borrowed from my colleague, Anna Lemke.

1:00:03

Who's in the department of psychiatry at Stanford.

1:00:05

The next time you eat a piece of chocolate or you engage in a behavior that feels particularly delicious.

1:00:11

Notice the sensation and the thoughts in your mind, it's rarely about complete presence and desire for staying present.

1:00:20

It's usually a desire for more it's this.

1:00:24

I want more of this, please, as opposed to really basking in the experience.

1:00:28

And I should mention that Anna has a wonderful book coming out in August called dopamine nation.

1:00:35

She was in the social dilemma.

1:00:36

She's an addiction therapist and psychiatrist and talks a lot about the dopamine system.

1:00:41

So dopamine makes us want more of whatever feels really good, and that tends to place us in an external focus, serotonin another feel good molecule is exact opposite.

1:00:52

It tends to make us feel good with what we already have.

1:00:55

It tends to be the incredible feelings of warmth that, you know, holding a child or a loved one or time with your dog.

1:01:04

I have this bulldog Costello, and there's times when I just sit with him and I feel immense pleasure just being there.

1:01:10

I don't think I want for bulldogs.

1:01:11

In fact, I definitely don't want for full blocks.

1:01:13

The snoring is loud enough already, but it's about experiencing the here and now in a full and complete way.

1:01:20

MDM is unique because it creates huge increases in dopamine and serotonin at the same time.

1:01:28

And we don't ordinarily see that in natural experience.

1:01:32

And it has this unique property of making people feel very excited and positive about their relationship to their internal state.

1:01:41

And so it has a kind of looping back of a mechanism that normally would place us in the viewing of the exterior what's out there.

1:01:49

What can I get more of? Who can I interact with more of what drug can I take more of?

1:01:53

That's going to make me feel this way. So MTMA is very unique.

1:01:56

And I mentioned it because it has certain correlates with hypnosis in that it's a very focused state in fact, so much.

1:02:04

So that let's just say, I could imagine that if you're hearing music and you focus on that music, you can really kind of start to merge with the music.

1:02:12

Whereas if you focus on your internal state, you can merge with your internal state.

1:02:15

And that's why I do think it's important that some of that, if people are doing it in a clinical setting, be guided because otherwise the experience can be sort of lost on whatever is external, other psychedelics of the sort like silicide and LSD.

1:02:29

They have a very sleep like state.

1:02:31

They are tend to be more serotonergic in nature, and they are very similar to sleep in the sense that space and time become very fluid, whatever top-down governing mechanisms exist in the brain.

1:02:43

So-called, you know, executive function.

1:02:45

Some of that seems to be dysregulated enough so that inside of those psychedelic states and in certainly inside of dreams, anything can really happen.

1:02:55

And you can essentially see and appreciate novel associations that normally wouldn't occur in waking states.

1:03:02

We should remember that the two extremes of human experience are stress and or excitement.

1:03:09

So highly contracted visual window, highly contracted time domain.

1:03:14

Everything's sliced very finely what's happening next.

1:03:16

What's going to happen next. Think you're in the line at the airport.

1:03:18

And the first in front of you is moving slowly and you got a plane to catch everything constricted to right there, both in space and time, and then sleep where in sleep space and time are extremely fluid.

1:03:30

Anything can happen and you are essentially out of control mentally.

1:03:35

It's just, whatever is going to happen is gonna happen.

1:03:37

Psychedelics are very much like that, except that in LSD and psilocybin assisted states you're alert.

1:03:43

So I would say that siliciden and LSD like states are similar to hypnosis in that way, but hypnosis has a little bit more of a rigidity to it.

1:03:52

It's set toward a particular focus, like let's work on your control over stress or smoking or pain.

1:03:59

And so I would say the three of them occupy neighboring spaces, but none of them overlap completely.

1:04:06

That'd be so curious to see some type of multimodal study and perhaps they've been done, but just looking at pharmacological interventions combined with hypnosis, right?

1:04:19

So if we made hypnosis the, the default sort of control state, and then you had an arm that was comparing hypnosis plus fill in the blank, not necessarily psychedelics, certainly.

1:04:32

I mean, you could, it could be an intact degenerate and pathogen, like MTMA, it could be a tryptamine like psilocybin, or it could be like a phenethyl amine, like Mescalin, which has very different effects.

1:04:45

Certainly I think that a Michael Pollan does a good job of describing this in his new book.

1:04:51

Your mind on plants is in that entire section discussing the Mescalin experience, which is really in a sense, an amplification of the real in high resolution, certainly dose dependent versus transportation, Allah, the tryptamines like LSD or psilocybin.

1:05:09

That'd be very, very interesting to see It.

1:05:12

Would I, and I have to say, you know, as usual you're you're five years or more ahead of else, Tim

1:05:17

and I don't say that at, for sake of flattery.

1:05:19

I mean, you, you have a, you have a way of spotting the horizon, and I think we are so caught up as a culture now in asking, what should we do?

1:05:27

What should we take? What device should I use?

1:05:29

I always say you've got behavioral tools.

1:05:31

We all have to eat sooner or later, nutrition, supplementation, prescription drugs, off-label and on-label.

1:05:38

And then you got brain machine interface, devices for reading and writing to the nervous system and body for measuring things and changing things.

1:05:44

And we always think of those as separate bins, but as you're pointing out, I think the most interesting Ben is to consider, well, maybe at some point, a learning bout is going to be 300 milligrams of alpha GPC and a particular breathing protocol that will have a synergistic effect.

1:06:01

I think that's where the real immediate future of beneficial brain change lies.

1:06:06

And I think even the folks at neural link, you know, a guy that came up through my lab, he's a neurosurgeon, Matt McDougall is at neural link now, and they have other excellent neuroscientists there.

1:06:16

And you can be sure that they're thinking clinical issues first.

1:06:19

And they're thinking obviously, brain machine interface and chips and robotics and things of that sort.

1:06:24

But you can bet just given who makes up that company of roster, that they're all probably also thinking about ways to accelerate plasticity using a combination of brain machine interface and pharmacology.

1:06:35

And if they're not thinking about that, they definitely should.

1:06:38

So I think for the typical person who's knocking plant a chip beneath their skull.

1:06:41

I think you're hitting the nail on the head, which is that we need to think about what works independently and combining those for sake of synergy.

1:06:49

That's, what's going to get us where we need to go much faster.

1:06:53

I also think just to build on what you said and thanks for the kind words that when you look at these possible synergistic combinations, you could also end up and then this is not a certainty, but it's a possibility having a much more appealing risk benefit calculus in the sense that if you can lower the required dose of a pharmacological intervention, if you can lower the exposure necessary with some type of neurofeedback or neurostim like a TMS or a tDCS or any of these other tools, if you're able to lower the required doses of several things, when they're used in combination and get a similar or better outcome, it just has such incredible ramifications for the, for the clinical use of these things.

1:07:44

Let's take a step back here.

1:07:46

So now we've covered a bunch of the research.

1:07:49

We've covered a bunch of the sort of tactical practical implementations of some of the research findings.

1:07:57

Now I want to paint a picture for people who don't, who don't know you at all.

1:08:02

So we've already covered Castello. We have not discussed the fact that you have, it looks like full sleeve tattoos on both arms.

1:08:11

I think you're the guy. I think you outed me. Yeah, there's a, you're the first that's the first.

1:08:14

It's true.

1:08:16

Alright. Birthmark. They're all birthmarks.

1:08:19

Of course. They're all birthmarks kids.

1:08:21

Don't start because they're like potato chips.

1:08:23

I get just one And

1:08:26

we may get to Aqua scaping.

1:08:28

That's a whole separate conversation.

1:08:30

So we may get to that. But I want to, I want to rewind the clock for a second because I read your bio, obviously, very impressive.

1:08:36

Bio you've received numerous awards.

1:08:39

You've produced a lot of incredible work with your colleagues and your lab.

1:08:45

Let's go back to what happened to you in July of 1994.

1:08:53

So in July of 1994, I was living in a little town called Aila Vista, which is near Santa Barbara.

1:08:59

It's the home of UC Santa Barbara university of California, Santa Barbara, just as a little bit of background, I was not a good high school student.

1:09:08

I had a very disrupted high school experience despite growing up in a, in a good area, just a lot of tension and stuff at home.

1:09:17

So I'd barely finished high school, but I followed a high school girlfriend off to college.

1:09:22

Somehow I got in at the time I wanted to be a firefighter, took fire science courses at mission college in the south bay.

1:09:29

And I thought it'd be a firefighter.

1:09:31

And I put that in my entrance exam.

1:09:33

And somehow they let me in.

1:09:35

But by the end of my freshman year of college, I had terrible marks.

1:09:39

I had been thrown out of the dormitory living for getting in fights, something I'm certainly not proud of.

1:09:48

And I was basically doing nothing that summer I was living in.

1:09:52

I was squatting. I was living in an empty house because a lot of the houses were empty.

1:09:56

I figured why pay rent, you know, and living in an empty house with my pet ferret and to sort of set the context, right?

1:10:05

I was, I think I was still grappling with a lot of anger and resentment and confusion based on having a rather confusing teenage years and, and a lot of disruption.

1:10:15

Fortunately, I'd formed a lot of friendships and formed a community in the skateboarding and punk rock culture.

1:10:21

I was fortunate enough to get to know a lot of guys that have gone on to do great.

1:10:25

Like my friend, Carl Watson is Adidas skateboarding.

1:10:27

I, I spent some time and got to know, although we weren't close friends with the great Denny way, probably the great one of the greatest skateboarders of all time jumped the great wall of China, but I wasn't a very good skateboarder.

1:10:37

I was not a musician. I knew how to do essentially nothing.

1:10:41

Well, and July 4th, 1994, I went to a barbecue with some friends and some guys were robbing the house that we were having this party at.

1:10:52

We came back from the store and we saw these guys essentially taking a bunch of possessions out of the house.

1:10:57

And the thing erupted into this big fight, this huge melee, I definitely went in excited to fight.

1:11:05

I've been involved in fights before, and I had an adrenaline seeking thing.

1:11:09

I felt like it was justified.

1:11:11

I'm certainly encouraging anybody else to do this.

1:11:14

But essentially what happened was my friends took off.

1:11:16

My so-called friends, took off and I ended up in a fight with a four or five guys.

1:11:21

Knives came out bottles.

1:11:23

It's the sort of thing where quickly you realize that things can go badly wrong.

1:11:28

Fortunately, I stayed on two feet and nobody got badly hurt or killed.

1:11:34

The police showed up.

1:11:35

And actually because of the fact that they were robbing us, they actually congratulated me.

1:11:40

I'll never forget. This is actually what made me feel worst of all.

1:11:43

It was one of the police officers said, you know, like nice work or something like that.

1:11:47

And I, and I just realized that I was in serious trouble.

1:11:50

You know, I'm 19. I barely finished high school.

1:11:54

I barely scraped through my first year of college.

1:11:56

I'm living in a squat with my ferret.

1:11:58

My girlfriend had left me.

1:12:01

I didn't do anything. Well, I didn't know how to do anything well.

1:12:05

And so that day, and I still have this letter, I actually sat down and I wrote a letter to myself and to my parents saying that I was going to turn things around.

1:12:17

I don't know why I wrote to them because at the time I was kind of avoiding contact with them entirely.

1:12:21

I've since formed a really good relationship with both my parents.

1:12:23

But I decided that day that I would use the one power that I seem to have, which is to remember facts and information.

1:12:34

And what I did was I left Santa Barbara.

1:12:37

I took a leave of absence, went back, went to a local community college in the bay area.

1:12:41

I did two quarters there and I just started studying like a maniac first psychology, then biology.

1:12:48

I eventually fell in love with neuroscience and related themes of endocrinology.

1:12:53

And the rest is sort of history in terms of eventually going to graduate school and getting a PhD and coming and professor tenured and all that stuff.

1:13:01

But it was one of those moments where I realized I am no longer going to be a young screw up.

1:13:10

I'm going to be a 20 year old screw up.

1:13:12

And with time, people are going to be less and less forgiving and whatever had happened prior.

1:13:17

No one's going to care.

1:13:19

It doesn't even really matter.

1:13:21

And if I do want people to care and it's not like I have a need to talk about the challenges early on, but I need to get my act together.

1:13:28

I need to do something. I need to get good at something.

1:13:30

And so I became a kind of a maniac actually, when I read your book, the four hour workweek in the F and the four hour body, which I read and loved and own, I should say again, not for sake of flattery because they, but they really helped me.

1:13:42

There are a lot of useful tools in there. There were certain things that resonated.

1:13:45

I figured out that if I drank a lot of coffee and took certain supplements, I could focus for many hours.

1:13:52

And then if I worked out, I built another capacity.

1:13:55

And if I ran, I built another capacity for endurance.

1:13:57

And I started to explore the crossovers between weightlifting is one thing it's not about building muscles or necessarily maybe it's about that.

1:14:06

It's about really moving against a physical force in real time.

1:14:10

And really learning how to do that. Endurance work is about learning how to push through a different kind of barrier and learning the carry over and crossover points.

1:14:18

So I was the guy that would sit down at my desk.

1:14:20

I moved, I decided to live alone in a studio apartment, and I would set a timer for several hours and I wouldn't allow myself to get up.

1:14:27

I was allowed to listen to rancid, best band ever for me on repeat and Bob Dylan, that's all, I wouldn't even allow myself to change music.

1:14:37

And then I would just sit there and I would read my textbooks, underline my textbooks, write my textbooks.

1:14:42

And I just decided I'm going to get straight A's marks.

1:14:45

I'm going to go to graduate school. I'm going to get a PhD.

1:14:46

I should mention. There were people that came up along the various times and helped me role models, mentors, people that spotted that.

1:14:53

But it started with a switch that flipped on July 4th, 1994 and getting in a bad fight.

1:15:00

And I am deciding to choose a different path.

1:15:04

So I want to underscore or explore a few things.

1:15:08

And I really appreciate you sharing this because I think it's very easy for people listening to folks with a bio like yours, to sort of assume a certain trajectory to assume that it has always come easy.

1:15:25

And that you've always, since you were two years old known exactly which direction you were heading, which is not the case.

1:15:31

One clarification with UC Santa Barbara, this might be an important point.

1:15:36

It might not. You did not drop out.

1:15:38

You took a leave of absence. Is that right?

1:15:40

Is that material to the story? Because I know in a lot of cases, there are folks who are kind of painted as dropouts, but in fact, they kept their options open by taking the leave of absence instead.

1:15:52

So I just wanted to clarify, Yes.

1:15:55

A leave of absence is a mechanism that most universities have.

1:15:58

I think it was designed for things like family situations.

1:16:01

If somebody gets pregnant or they have a family member who's sick that allows you to leave and come back and it's distinctly different from dropping out.

1:16:10

Although I was pretty close to dropping out of being forced to drop out for reasons related to poor grades and poor behavior.

1:16:16

Fortunately, that didn't happen.

1:16:18

I think it's a really important point because we hear that bill gates dropped out of college.

1:16:23

Steve jobs dropped out of college. Mark Zuckerberg dropped out of college.

1:16:26

I think maybe it was Ryan holiday, who, I don't know who said, something like that.

1:16:31

The people who are doing poorly in college, they're the ones that should stay in college because it's the one environment where everything's scripted out for you, what you need to do in order to hit the next metric of success.

1:16:42

And a leave of absence is very different.

1:16:45

None of those people dropped out of college.

1:16:47

They took leave of absences that gave them an insurance policy that they could go back if they wanted to.

1:16:54

And it's very hard to make it back into a system of any kind, but it certainly is much harder if you completely divorce yourself from that system.

1:17:02

I am a believer in formal rigorous coursework.

1:17:05

I am a university professor. I know that college isn't perfect for everybody.

1:17:09

It's might even be the wrong decision for certain people, but if you're still uncertain about what you want to do, I think if it can be arranged financially and it's in the scope of things that somebody might want to do.

1:17:23

I think learning how to sit down in a chair and force yourself to learn and then compete with others in terms of how well you learn that information, I think is a great way to evaluate oneself early in life.

1:17:34

And it sets the stage, right?

1:17:37

I agree with that. If you're open to it and certainly you can say no, or we can talk about it and then you can elect to have it edited out of the conversation.

1:17:45

But you mentioned tension and stuff at home disruption, are you open to sharing a bit more detail about what you mean when you say those things?

1:17:58

Sure. So I had a pretty magical childhood.

1:18:02

Really? My dad's a scientist. My mom wrote children's books and was a teacher.

1:18:06

We ate dinner as a family, everybody together in the early part of my life.

1:18:11

I, I acknowledged that I had great privilege in having that experience and growing up where I did good schools, good public schools.

1:18:18

I completely acknowledged the benefits of that.

1:18:21

Especially early in life, around 13, when I was 13, my parents split up and either because of the time in which it happened or because they weren't equipped with the right tools, there was a complete fracture of that picture.

1:18:34

My dad was very much out of the picture at that time.

1:18:38

My mom hit, I think, a series of challenges adjusting.

1:18:42

I think it was a ma what could only be described as a, a major depression.

1:18:46

I think her view of family was one in which everyone stuck together, no matter what she's from the east coast, she's from New Jersey.

1:18:54

Like you stick together.

1:18:56

It's why we had an argument the other day.

1:18:58

I don't think she'll mind me telling this. And like we got on and we were like ready to scrap.

1:19:02

And, but we haven't had one of those in years, but I just remembered that at the end of this conversation, we're going to be okay.

1:19:07

And at the end we were, we were closer.

1:19:09

So we both have that.

1:19:10

And I think for her, the fact that there was a complete disintegration of the picture, my sister out of the house and my dad out of the house and me there, she really hit the skids and home became a very empty very quickly.

1:19:23

It became a very empty and depressing place.

1:19:26

It was really, it was just really sad and I found care and love and community in the world of skateboarding.

1:19:35

This was the early nineties.

1:19:37

And there was this collection of mostly young guys at that time who would aggregate at Embarcadero Plaza, Justin Herman Plaza in San Francisco.

1:19:44

I started going up there and hanging out at the it's.

1:19:47

Now the famed EMB for it's kind of got a golden era reputation now.

1:19:52

And that's where I learned that you don't have to go to school.

1:19:57

There are a lot of guys not going to school.

1:19:58

There was a lot of drinking.

1:20:01

Lot of drug use a lot of wild behavior, but also I should say a lot of amazing skateboarding and amazing characters and personalities and fights and everything.

1:20:13

It was true street life. And so I started staying there.

1:20:15

I'd stay at people's houses or sometimes we'd even sleep there.

1:20:18

And I learned a lot about how people outside the cozy suburbs of the south bay, how they lived.

1:20:26

I'm grateful for that because it exposed me to the fact that many of these kids had no parental oversight from any age that they had to scrap for everything.

1:20:36

But quickly, I realized that I wasn't very good at skateboarding.

1:20:40

I didn't have a future in it.

1:20:42

And I wasn't going to school. My home life was really disrupted and I lapsed into a pretty serious depression.

1:20:49

I just remember, and anyone And

1:20:52

has experienced depression. I, I hope this will resonate with, although I I'm sorry that it exists, but there's this weird thing about depression, Which

1:20:59

is that it changes your Actual

1:21:01

view of the world. I remember leaving Embarcadero Sometimes

1:21:05

and looking up at the sky back then they had the Embarcadero freeway and thinking the sky is so sad.

1:21:12

Like not the sky is a third as in separate object, but that the scene of the sunset is so sad.

1:21:18

And actually yesterday I was thinking about That's

1:21:21

because there's this beautiful sunset where I live.

1:21:23

And I thought, gosh, I haven't felt sad at the view of the natural world in so long it's.

1:21:29

And so it was clearly a shift in mind, Internal

1:21:31

state and fast forward.

1:21:33

What happened was eventually the school picked up on the fact my high school picked up on the fact that I wasn't going, they called them.

1:21:40

I mean, at some point I was sitting down with a school counselor and they had this guy in the room, The

1:21:45

room with me sitting there.

1:21:47

And pretty soon I realized that I was in a different kind of situation.

1:21:53

And I realized they were going to probably try and take me away because I was completely truant.

1:21:56

I hadn't gone to school. I was clearly depressed.

1:22:00

So that's what happened against my will.

1:22:02

And despite an attempt to run away, I was taken to a place up the peninsula, which was neither a juvenile hall nor a psychiatric hospital, but we were under lock and key.

1:22:12

And I was in there with kids, Dealt

1:22:17

with everything from sexual abuse to hardcore Core

1:22:20

substance abuse issues.

1:22:22

I'll never forget this. They said the kids in the, in the ward next door, they're crazy because they're really young.

1:22:30

And the adults in the ward on the other side, they're crazy, but you guys, you're not crazy.

1:22:35

And I thought, Well, that's ridiculous because they're probably saying the same thing to the ones on the other side, But

1:22:41

I had no one to call.

1:22:43

I called my Skateboard team manager out of sympathy, not because I was any good.

1:22:47

I'd got put on a, on a wheel company, in a truck company for skateboarding.

1:22:51

And I called them The guy. And I said, I don't know what to do.

1:22:54

I'm in this place. And, and he, I'll never forget.

1:22:57

He said, look, I can barely take care of myself.

1:23:00

And you're the most normal guy I know.

1:23:03

And I've realized at that point, I'm like, I'm really alone here.

1:23:06

So the long and short of it was I did the work.

1:23:10

I put my trust in the counselors that were there.

1:23:12

They seem to know Good people.

1:23:13

And you know, I did the work, but it's part of an agreement for getting, let Back

1:23:20

into school. Actually, it's part of an agreement for Being

1:23:22

led out. I had to do weekly therapy and I was fortunate enough that I got placed working with somebody who understood My

1:23:31

particular needs, worked with adolescents And

1:23:34

really encouraged me to start exploring my mind.

1:23:38

Certainly the situation I was in, but encouraged me to start Meditating.

1:23:41

He gave me John book, wherever you go.

1:23:44

There you are. He saw how much physical energy GI

1:23:47

had. And he encouraged me to start running, Hurting

1:23:50

myself skateboarding. And he said, well, maybe running or swimming and running and swimming are amazing because Unless

1:23:55

you really do it wrong, you can go and go and go.

1:23:58

It's just an, I could burn off all that anger and energy over time.

1:24:02

And then I started getting into weightlifting and the weightlifting, It's

1:24:05

kind of a double-edged sword. I should mention. I think it's one of those things that Is

1:24:09

great. But you know, if you exceed a certain size, it can actually Make

1:24:14

people kind of scared of you. So we're like the tattoos thing.

1:24:16

A lot of like a lot of the reason why I cover up tattoos is because then people just see the, see your tattoos, but it's true.

1:24:22

I started getting tattooed pretty young, the wrong way.

1:24:24

Don't do it this way with India ink and a needle.

1:24:26

This was before this was autoclaves that don't do it.

1:24:30

But I decided at that age that the therapy and this one person who seemed to really care about my mental and physical wellbeing and would spend the time was really worth investing in.

1:24:41

And I hid it from everybody because no one did therapy, then no one talked about it.

1:24:45

It's like late eighties, early nineties.

1:24:47

Nobody did that. Yeah. And I will confess, I don't think I've ever said this publicly, but I've found a way either through insurance or through my own income, I've continued Therapy

1:24:58

with that same individual now for 32

1:25:01

years. Wow.

1:25:03

And so I do, I confess, So

1:25:05

I do three sessions a week of psychoanalysis remote or in person.

1:25:10

And I know people have a lot of, they do the They're

1:25:13

kind of, eye-roll not the Spiegel eye-roll test, but the other kind of viral, when you say psychoanalysis, I think an exploration of the mind is extremely powerful.

1:25:19

It has to be done with the Right person.

1:25:21

And there's only one person I know who's done this kind of extended work for so many years and that's the late Oliver sacks.

1:25:30

Who's a kind of a hero of mine.

1:25:32

Also worked with a psychoanalyst for many, many years.

1:25:35

And so psychoanalysis a fight on J on July 4th, 1994, a lot of attempt to both stabilize my mind and also organize my behavior.

1:25:46

Those things go hand in hand, of course, but also biology to leverage.

1:25:51

I guess you could call it biohacking or you call it, I just call it biology.

1:25:55

I mean, when I learned, for instance, that taking A

1:25:59

thousand milligrams per day of EPA essential fatty acids, not just Fish

1:26:03

oil, but getting above that threshold is as effective as antidepressants in double blind placebo controlled studies.

1:26:10

You know, when I saw those papers, I realized, well, I probably have a bit of a leaning toward depression.

1:26:17

I'm going to do that now. Did I do that and drop therapy?

1:26:19

No, I do that in therapy. And I train and I try and work on my sleep.

1:26:23

It's a constant process, but biology and the information contained in books like yours and hopefully in the information that I'm trying to put out into the world now that that stuff helps in a major way too.

1:26:35

So it was a multi-pronged support system and many incredible mentors along the way.

1:26:41

But I was definitely at the edge.

1:26:43

I know you've talked about this public too.

1:26:44

I mean, there were times when I just thought, like why continue?

1:26:47

And I'm fortunate nowadays.

1:26:49

I feel very far from that.

1:26:52

There's a saying in that in the world of addiction and addiction treatment, which is that no matter how far you drive, you're always the same distance from the ditch that I would say is true of addiction.

1:27:02

Fortunately, at least in my own experience, that is not true of depression.

1:27:06

I have vowed to never go back to a place where living seems meaningless and anyone who's been close to that place, all I can say is the work works.

1:27:18

Whether or not it's therapy, biology, et cetera, you have to do it.

1:27:22

And there are things that can accelerate that process, but it's an ongoing battle, to be honest, While

1:27:29

you're fighting the good fight, man, I'm certainly right in there with you.

1:27:32

How does it feel to talk about this stuff?

1:27:34

It's interesting. I always get a little quickie on this.

1:27:36

I would say there are only two things that will always consistently make me cry.

1:27:40

And, and those are the thought of, I don't even want to talk about for too long because I prefer not to cry, but a one would be when my bulldog Costello goes that we're very bonded and he's close, unfortunately.

1:27:50

So he's in his final years. And the other is when I think about my mentors in particular, one passing away, talking about this gets me in a mode where it's uncomfortable.

1:28:00

I'm definitely uncomfortable this moment.

1:28:03

I'm okay to talk about it because I think these issues are important.

1:28:06

And I wholeheartedly believe that many people struggle with them.

1:28:09

You know, I'm always conscious of protecting the people in my life who were doing the best they could with what they had.

1:28:14

So, you know, my parents are good people.

1:28:16

That generation didn't have the tools that I had access to.

1:28:20

And I do hope the next generation and we'll have access to more tools.

1:28:24

So I want to protect them.

1:28:26

They, they are, you know, I'm blessed.

1:28:28

I acknowledge my privilege and I don't say that for political reasons, by the way, I just want to say, I acknowledge that I was born into a pretty fortunate, we're very fortunate situation that provided buffers.

1:28:39

And I only know my own experience, but I, I acknowledge it as real.

1:28:44

Thanks for sharing all of that. And a mutual friend has prompted me to ask about the Hoffman process.

1:28:53

Oh yeah. The Hoffman process. So the Hoffman process is a, it's a personal development process.

1:28:58

It's a full immersion week long process.

1:29:01

I think it used to be two weeks. I don't want to give away too much about it because if one were to go, you want to have the experience for the first time without expecting or knowing what's coming.

1:29:11

It involves a lot of both physical and kind of emotional purging.

1:29:15

And what's interesting is it's generally between 20 and 40 people go, you don't publicly share any of the issues that you're grappling with.

1:29:23

There is a teacher there that you communicate with and who knows a lot about your situation.

1:29:30

There's a lot of work that you do beforehand and paperwork.

1:29:33

So they really know closely what you're grappling with.

1:29:36

And you do get to know people there, but there are strict rules, no romantic relationships, no discussion of politics, no discussion work, no discussion of sports.

1:29:43

And you quickly find that you realize that you spend a lot of time thinking about and talking about those things in the outside world and B that there are other ways to connect with people that are very authentic, that don't involve those things.

1:29:56

Hoffman process was one of several things for me that was transformative for me.

1:30:03

It was most transformative in the realm of forgiveness.

1:30:06

I felt completely resolved of my challenges with, you know, inability to focus, complete work structure, et cetera.

1:30:15

I'd solved all that. I learned how to work hard perform well, by the time I went to Hoffman, which was in my early forties, I'm 45.

1:30:21

Now I learned how to control my physical landscape as best as one could or should I went there thinking like, why would I go here?

1:30:31

What's the purpose in going?

1:30:32

And yet I, I realized that I harbored a lot of resentment, mostly toward family members, but also toward experiences and, and, and people outside of my family.

1:30:44

And I almost got kicked out of Hoffman the first day, not for misbehavior, but because I slept through the first day I'd been working so hard.

1:30:52

They kept saying, you're trying to escape by sleeping.

1:30:55

And I'm like, I'm just tired.

1:30:56

Like they take really good care.

1:30:59

They take really good care of you. There.

1:31:00

I've actually never felt so nurtured.

1:31:02

I'm not somebody who accepts nurturing very easily.

1:31:05

I like to think I'm more of a caretaker and a more of a kind of caretaker loner type than being taken care of and Hoffman date.

1:31:13

I felt comfortable to be taken care of in certain ways.

1:31:16

And I discovered in doing the work that there were all these resentments and I was able to purge those resentments and I have to say it completely erased all feelings that I was wronged by anybody or anything.

1:31:32

And that's powerful and it's completely behavioral in nature.

1:31:36

There is no pharmacology there.

1:31:38

I would say Hoffman is among the two or three things that were maybe four or five things that were really transformative for me.

1:31:44

And there is a price point, but they do have a scholarship program that's been established thanks to the generosity of various folks.

1:31:52

So for people that can't afford the price point, they do have a fairly simple scholarship program where you write something out, people are practitioners, you know, therapists and in the wellness community.

1:32:02

I think also get a break of some sort.

1:32:04

I have no business relationship to Hoffman, but I've recommended that several people go and it is powerful.

1:32:10

And it does last.

1:32:12

In fact, the reason I decided to go to Hoffman was because somebody actually a mutual friend of ours, Tim, who I don't think when Wendy Yalom, who I know from way back when we haven't been in touch in years, but I think she said something about Hoffman.

1:32:26

And she said, she knew somebody who went and I contacted that person.

1:32:28

And that person said, I went to Hoffman and 10 years later, it still has a profound, positive effect on my life.

1:32:38

And I found it to be more useful than any other therapy or training of any kind.

1:32:44

That's my Hoffman story.

1:32:46

And it's powerful.

1:32:48

And for people who want to hear more about Hoffman, I talk about it at, at length, also with Blake Mycoskie in the last conversation I had with him.

1:32:57

So people can find that that episode, you mentioned one of four or five things.

1:33:02

What are some of the other things that have had a disproportionate positive impact?

1:33:08

This is a broad category, but get your biology right.

1:33:11

Start with sleep, figure it out, figure out how to get your sleep, right, because it's the fundamental layer of mental health.

1:33:17

So get that one, right?

1:33:19

Other things in the biological category are learn how to focus, learn how to de-focus learn how to flip the switch on, learn house, flip the switch off, get good at sleeping.

1:33:28

Of course, exercise of various kinds is going to be good and all the other things, but there's, there's that physical bin.

1:33:33

And those are the primary leavers there.

1:33:36

I do think some form of exploration, whether or not it's psychoanalysis, psychotherapy, journaling, or some sort of internal reflection, that's somewhat unregulated, but obviously not damaging to you or anyone else.

1:33:52

So don't punch concrete walls, but have the ability to sit down and data dump and reflect.

1:34:00

If you can't afford therapy, reflect on what you're seeing and reading and feeling have the ability to experience what's internal.

1:34:08

So that would be the second one.

1:34:10

The third one is an, I realize there's some issues around legality and things.

1:34:16

And right now everything's in transition.

1:34:18

I was part of a clinical trial.

1:34:20

So I can safely say this.

1:34:22

You know, I do think that there are certain aspects to let's just call it what it is, either plant medicine, or I was part of MTMA assisted psychotherapy trial.

1:34:33

That was extremely valuable.

1:34:35

There's no question to me that that's a powerful mover of one's ability to feel comfortable in internal state.

1:34:44

The way I would just briefly describe that experience for me is that I could feel and perfectly fine from here to here and from the belly button down.

1:34:52

But I had this feeling always that I couldn't kind of experience things in mind and body at the same time.

1:34:58

I know this is gonna sound really wacko to people who maybe haven't experienced this, but somehow in that brief experience, I was able to resolve that.

1:35:07

And I now experienced my nervous system as a complete entity.

1:35:10

And I do not think people should cowboy this stuff and do it on their own, or try and do therapy for their friends or do this on their own.

1:35:18

I don't think this is something that people should play around with.

1:35:20

These are very powerful tools. You should do this with a board certified MD sign up for a clinical trial.

1:35:25

Hopefully this will be done in the, you know, in these sorts of medical settings soon, legally, and you don't have to be part of a clinical trial, but if you struggle ongoing in some way, I do think there's utility there.

1:35:39

So that's another bin. And then there's another bin, which for me has been very powerful, which is stay on the adventure, continue to have fun.

1:35:47

It's so easy to forget, to have fun when you're doing all these other things like stay in the adventure and don't get killed doing it.

1:35:55

But, you know, really try and keep exploring.

1:35:58

I do believe these dopamine systems are positively reinforced by novelty and exploration.

1:36:04

We know that and by venturing into new territories and that requires getting certain things wrong, it means going to a retreat that sucks.

1:36:13

It means taking a class that is not that interesting.

1:36:18

It means finding out that, you know, a particular relationship is not right for you, but it's important to stay in a mode of adventure because that's fundamental to the human experience.

1:36:29

And it's fundamental to these neurochemical systems as well.

1:36:33

Well, the points I'd love to underscore here, so the biological piece you've discussed in other places, this principle, it's a quote of sorts of Maxim that I think is really worth remembering.

1:36:47

And I'm saying that to myself, as much to anyone listening that as you cannot control the mind with the mind and whether or not there might be exceptions to that.

1:36:56

I think as a general rule through using the BI directionality, as you've mentioned, sort of body mind, mind, body, and you know, when in doubt working through your fuller biology is incredibly powerful.

1:37:11

I mean, for me like to get out of my head, I need to get into my body if there's just no metacognitive way, generally for me to otherwise do that.

1:37:21

Or if there is, it's just much more difficult, I've even told my girlfriend.

1:37:25

I'm like, if I'm trying to figure out what is bothering me and I spend more than like a half hour on it, just tell me to go to the gym and lift heavy things for at least 30 minutes.

1:37:36

That's the best remedy in the world.

1:37:38

And then I come out, I'm like, yeah, That

1:37:40

bullshit's fine. It doesn't matter. And that's what was necessary on the adventure side actually, before I get to the adventure side, just a quick note on Costello, because I think a lot about my dog, Molly and mortality, and it's just, it's like so easy to get sad.

1:37:58

And how old is she?

1:38:00

She's seven, but she's had some health issues.

1:38:03

She's had two spinal surgeries.

1:38:04

And if you haven't looked into the canine research with Rappa rapamycin, I would look into that.

1:38:14

It's very, very compelling.

1:38:15

So that might be, I'll

1:38:17

do that. I listened to your podcast with Peter TIAA and a lot of discussion about rap myosin.

1:38:23

I I'll definitely check it out.

1:38:25

Yeah. It's, it's worth checking out. There's also a separate episode with David Sabatini of MIT, who is a genius and, and it's sort of M Tor wizard who said Family,

1:38:38

his, he has a brother Bernardo Sabatini.

1:38:41

Who's a famous neurobiologist at Harvard who I know quite well.

1:38:45

And their dad, there's another Sabatini who is at NYU med.

1:38:49

So those 17 days, they're kind of like the Kornberg's Kornberg discovered RNA.

1:38:52

His son discovered the structure of RNA.

1:38:54

They both got Nobels and I think their brother is an immunologist, something like that.

1:38:58

So if your last, if you're thinking about changing your last name, Sabatini or Kornberg is a good one to select Not,

1:39:05

not bad. Yeah. They come from the secretariat stock scientific gene pool on the adventure side.

1:39:12

So you said don't die or don't let something kill you, which I think is a perfect segue to, as I'm reading it from a paragraph from outside magazine, Huberman was about 40 miles off the coast of Mexico and 40 feet below the Perry Winkle surface of the ocean.

1:39:28

What does this refer to?

1:39:30

Oh my, yeah. So before I went to Hoffman, I was still working out some things, the quick backstory, this is in 2016, I decided I was going to shift a lot of my laboratory work toward humans.

1:39:43

I understand the issues of animal research and why it's important.

1:39:47

My lab still does work on mice because there's certain things you can only do on mice, but I want to work on humans and I want to use virtual reality to induce fear in the laboratory and study stress and fear and other brain states.

1:40:00

And we realized that VR, as it stood at the time was just pretty lame.

1:40:05

It was computer generated images.

1:40:07

It didn't have 360 video or sound.

1:40:09

And so I got linked up with a guy named Michael Mueller, M U L L E R.

1:40:15

Who's a very, very famous photographer in Hollywood.

1:40:19

Mostly does all the Marvel stuff.

1:40:21

He shot everybody that you just can go to his website.

1:40:24

It's just, it's kind of a, just a constant scroll of iconic images, Mueller and I got to be friends.

1:40:30

And the reason I was excited about getting to know him is because a hobby of his is that he takes photos of great white sharks under water.

1:40:39

He brings these giant strobe lights, underwater, and Mueller is, you know, you hear about the character of the Wolverine Hugh Jackman, right?

1:40:46

Mueller is a Wolverine.

1:40:47

He's kind of hunched over and he's the nicest guy in the world, but it was like, It

1:40:53

was immediate friendship, but he loves adventure.

1:40:56

He's got, he's got a family, kids, everything, but he loves adventure.

1:40:59

And he said, this is my best Mueller personation.

1:41:02

He's like, bro, you gotta come down to Guadalupe.

1:41:04

The sharks are there. And I was like, well, what are we going to do?

1:41:07

And he's like, well, we'll just film them with 360 cameras.

1:41:09

So in 2016 we went down there and we filmed great white sharks as a stimulus for this fear laboratory that we were building and got 360 video.

1:41:21

And the way we did that was that Mueller and a couple of other guys, these expert, great white shark divers would leave the cage.

1:41:27

You lower the cage about 40 feet below.

1:41:28

And they leave the cage to come back in. So called cage exiting, definitely illegal to do.

1:41:33

We got permits from the Mexican government because this was for a scientific study.

1:41:38

I would have loved to see that permitting process anyway, continue.

1:41:41

Yeah, that was something else. So we, we got the footage, brought it back, built this thing up.

1:41:45

And then what happened was in the subsequent year, the technology for VR really improved.

1:41:50

So we decided we were going to go back and I decided for whatever reason that I was going to cage exit also, I actually learned how to scuba dive for the first trip, but I'd stayed in the cage.

1:42:01

And so the second trip we went out there and I brought a good friend of mine who was actually a mutual friend through Blake Mycoskie.

1:42:08

Pat Dawson is a former former seal team guy.

1:42:11

I brought Brian McKenzie because Brian learned Brian Mackenzie learned how to scuba dive in a lake in Oregon.

1:42:18

And his first ocean dive was KJ exit with great whites.

1:42:23

Now of course, the guy Has unscarred tattooed on his knuckles.

1:42:26

I know he was featured in a number of your books.

1:42:29

So it was Brian pat, me and some other guys.

1:42:31

We went out there with the intention of getting better footage to create a very realistic VR experience of great white sharks.

1:42:38

So what happened was on the first day, I decided I'm not going to cage exit today.

1:42:43

Let pat go. He's a seal team guy.

1:42:45

He'll do it. He did it of course masterfully the first time when a few meters beyond everybody, because those guys aren't competitive or anything anyway, it all worked out.

1:42:54

But the first day I was in the cage.

1:42:56

So I went down, I've been in the cage before and you're breathing off of hookah line, which is up to the surface.

1:43:01

You're not on scuba. And the reason you don't bring scuba is because you don't want to take up too much space in the cage.

1:43:06

So the other divers Mueller and a couple other guys had left the cage and I was there just watching the sharks and really enjoying it.

1:43:12

I'd been down there the previous year and these great white sharks, their girth, isn't incredible.

1:43:17

And they come at you on like a Volkswagen and they'll stop right in front of you and hover.

1:43:22

They'll eyeball you and then disappear into the darkness.

1:43:26

Sodas. It's really amazing.

1:43:27

And I realized as I was down there, I'm like, I'm alone in the cage.

1:43:31

This time. I've never been alone in the cage.

1:43:32

We had a lot of sharks that day. So I was moving around and swiveling around a lot.

1:43:36

And then all of a sudden I had no air, nothing, just nothing coming through the mouthpiece.

1:43:42

And I looked up and the hookah line got all boa, constricted up.

1:43:47

So I popped up to it thinking I'll just untangle thing.

1:43:51

And it's like hardest concrete. I was like, oh good.

1:43:54

So I took another suck of air and nothing.

1:43:56

And I looked down their safety tanks in the two corners.

1:43:59

So I Spit out the mouthpiece.

1:44:01

I dropped down to the safety tanks, open Them

1:44:03

up and the needle doesn't move.

1:44:05

They're empty.

1:44:05

This

1:44:05

is

1:44:05

like

1:44:05

the

1:44:05

biggest

1:44:10

nightmare. And it's interesting. We were talking about Costello.

1:44:12

I had one thought at that moment, a totally inefficient use of mental space, but the one thought was, I'm going to go home alive.

1:44:22

I'm going to see Costello.

1:44:23

He just popped into my head.

1:44:25

So this stuff really does happen apparently.

1:44:27

So nothing off the safeties tanks.

1:44:31

So I decided I got to get out of here when there's sharks everywhere, but I've got to get to the surface and you're just desperate for air.

1:44:39

So I pop up to the top of the tank and I've got a weight vest on and I've got to take that weight vest off.

1:44:45

If I want to get up to the surface. Now the sharks actually don't eat you when you're outside the cage.

1:44:49

If you're swimming, They

1:44:51

actually, if you loom on them, they steer away.

1:44:53

That's the way that these cages exit Divers

1:44:55

are able to avoid getting eaten.

1:44:57

Or if you're ocean Ramsey, you just kind of understand them and you'd swim next to them.

1:45:02

But I was genuinely frightened and stressed.

1:45:04

And so I thought, okay, I'm going to Shoot

1:45:06

for the surface. I could see the silhouette of the boat.

1:45:08

I'm going to shoot for the surface. I'll either get eaten or altered, But

1:45:11

I'm certain I'll drown if I stay here.

1:45:14

And then what happened was one of the divers, his name's Brock saw me and started kicking back Toward

1:45:23

me. And he's carrying this big vacuum, cleaner Size,

1:45:25

the AR thing.

1:45:26

And that felt like an eternity.

1:45:29

You know, he's coming back to me Back

1:45:31

me slowly. So I know I'm just hoping if I pass out, I want to fall into the cage.

1:45:35

If I float, I want to make sure I float up, but it was a good 20 or 30 more seconds, which doesn't sound like very long, but it's not like a, Yeah,

1:45:43

there was an eternity. So he made it back.

1:45:45

We did the share error thing, but then we added a whole other problem, which was that we're sharing air.

1:45:51

Those guys are out there. We're now on One

1:45:53

tank and the safeties are empty.

1:45:55

So now There's a chance that we both might have to shoot for the surface.

1:45:59

So fortunately everybody made it back in time And

1:46:02

we got up to the surface, but I will never forget that experience.

1:46:07

I do feel like I'm on borrowed time and I did feel quite traumatized by it.

1:46:13

And I will say that that night I did one thing and the next day I did something else was that night.

1:46:18

I, I was able to sleep. I did yoga nidra and I was able to calm my mind and my nerves and the next day, because I, I understand a bit about the relationship between trauma and exposure.

1:46:30

I did go back down the very next day and I cage exited and some people might think that's foolish.

1:46:36

I certainly didn't do it to be tough.

1:46:38

Or does it seem like I'm tough? I did it because facing the trauma is the best way to purge the trauma.

1:46:47

We know this and KJ exiting for me, allowed me, I believe to report the experience.

1:46:52

I feel nothing in my body, no tension, no stress, no quaking or anything related to that.

1:46:57

So I do think it's been completely purged.

1:47:00

I want to dig into what I read as a definition of fear from you.

1:47:06

And just to hear more about your fascination with fear and where it comes from.

1:47:13

So here, here's what I have. And you can fact check this, please.

1:47:16

Quote, fear. It's the anxiety that you feel when you don't know what behavior can remove a feeling of helplessness in the face of a threat and quote, does that sound right to you?

1:47:29

You can't have stress without anxiety.

1:47:30

You can't have trauma without stress, but you can have stress or anxiety without trauma.

1:47:38

I think that the key variables are anxiety as a state of heightened alertness is contracting in the visual field, quick of the heart rate, breathing, all that kind of standard stuff that we hear of sympathetic nervous system activation.

1:47:49

But the mental component is one in which time is being sliced very finely.

1:47:56

So you're constantly anticipating in evaluating your environment and your internal state, because oftentimes people are aware of their so-called interoception, they're keenly aware of how nervous they are upset.

1:48:08

They are. And this element of uncertainty, of being unable to predict when it's going to pass.

1:48:16

And this creates a kind of meta stress is sort of like when people have trouble sleeping, then they create this kind of meta anxiety and insomnia there.

1:48:23

Now they're stressed about not sleeping. And so then it makes it even harder to sleep.

1:48:27

The same thing with stress, the more we stress, the more we want the stress to pass.

1:48:30

And I think that resolving the uncertainty element is powerful.

1:48:37

And I think it starts by taking control of the mind through the route of the body when our mind is not stable, whatever that means, but we're not able to control our mental state or it's not where we'd like it to be.

1:48:51

We need to look to the powers of respiration, of vision, of movement, of weight, training, of running to reorient the mind.

1:48:58

I think it is futile to try and rescue thinking with thinking.

1:49:02

That's not to say that thinking and an exploration of the mind like with psychoanalysis or journaling is not powerful, but for restabilizing our system, these brain states of mind and body, I think the body is the more powerful entry point.

1:49:18

And have you always been fascinated by fear?

1:49:20

Or why, why did that become a focal point?

1:49:24

Probably because I was the kid that was last to drop in on the ramp, probably because I have lived in existed with a fair amount of fear.

1:49:34

This seems to have gotten better over the years.

1:49:38

For instance, I can remember skateboarding home, there's this bike path that used to connect the school that I went to the back of some houses and I would push back through at night.

1:49:47

And I would start to imagine that terrible things were going to happen to me.

1:49:52

I think that fear was, it was a strong default and I can't assign that to any earlier experience.

1:49:57

I think I just had a lot of baseline anxiety and fear, and so resolving that and figuring out tools that people could use that I could use also to resolve those things really fast has been a major, a major effort in my life, including my laboratory.

1:50:15

I'd like to, if it's okay with you shift gears a little bit and just pepper you with a bunch of random questions that have absolutely no continuity with anything we just talked about.

1:50:24

Great. That's okay. Sure thing.

1:50:28

All right. Because I just, I have this sort of scratch pad full of these various things that I want to ask about often without a whole lot of context, just from, from various reading and so on.

1:50:37

So turmeric's effects on DHT.

1:50:39

Could you elaborate on this?

1:50:42

So DHT, dihydrotestosterone, I'm guessing what should we know about DHT in turmeric's effects on DHT?

1:50:48

And I ask in part, because it's something that I use all the time in cooking there's seems to be some research to suggest that products like thera acumen, I believe it's called, is the brand name might attenuate some risk related to say neurodegenerative disease or Alzheimer's.

1:51:04

So I'd love to know more about this.

1:51:09

Yeah. So brief endocrinology lesson on testosterone, DHT testosterone is the androgen.

1:51:14

Of course that's responsible for muscle growth deepening the voice regression sex drive, et cetera.

1:51:20

But DHT dihydrotestosterone is made from testosterone through an enzyme called five alpha reductase.

1:51:25

DHT is the more powerful androgen anywhere from 300 to 600 times.

1:51:31

The affinity for the androgen receptor DHT is the end its affinity for the androgen receptor.

1:51:37

Not so incidentally is the basis of nandrolone DECA known in gym circles, actually a female runner that was a good pick for the 1500, just got a four year ban, oops, or a nandrolone positive test.

1:51:53

She claims and her coach claims that it came from a burrito containing pork with nandrolone.

1:51:58

I actually would love somebody to go explore.

1:52:01

We're going to see more of this in the years to come.

1:52:03

I'd like somebody to actually analyze meat for Clenbuterol and nandrolone to just see cause the, and I'm not happy that this happened or it's, it's a sad situation, but we could fairly say that there's been a dark shadow cast by a burrito over the Olympic qualifications.

1:52:19

It's

1:52:19

kinda

1:52:19

like,

1:52:21

Well, all the sprinters were diagnosed as narcoleptics you remember that with a really Medallia for all?

1:52:27

Yeah. They're all on Modafinil and various stimulants.

1:52:29

And so they had these scripts from their doctors and letters saying they were all narcolepsy.

1:52:32

It's just amazing.

1:52:33

The Venn diagram To

1:52:36

get them quick out the blocks. That's where the race is one here, that gun and get out the blocks.

1:52:39

That's so nandrolone is DECA.

1:52:41

The reason people take it, whether or not she took her in.

1:52:44

I know, but the reason People take it is because DHT as the more powerful androgen with this higher affinity is the one that's mainly responsible for libido.

1:52:55

And many of the cognitive effects of testosterone.

1:52:57

One of the more powerful effects of testosterone is that because of the fact that there are androgen receptors in the amygdala, that it has a fear suppressing component to it and DHT testosterone, but really DHT has a property of making effort feel good.

1:53:17

That's probably the main psychological effect of testosterone aside from its effects on, on libido and the body periphery.

1:53:25

So some people are very DHT sensitive.

1:53:29

If you're somebody, for instance, that takes Creotine and experiences, hair loss very quickly.

1:53:35

You're probably dead. She senses that's because creatine increases DHT.

1:53:39

DHT will promote hair loss on the scalp.

1:53:42

Like my hairline's retreating quite nicely and outlet because of DHT receptors here and it promotes beard growth.

1:53:48

So it has these adverse effects on the face and on the scalp.

1:53:51

But tumeric is a fairly potent DHT antagonist.

1:53:57

Now, whether or not it does that by occupation of the androgen receptor or some other mechanism, I don't know.

1:54:02

People will vary in their sensitivity.

1:54:04

I am very sensitive to tumeric.

1:54:06

If I take tumeric, my DHT levels plummet, and I'm not taking nandrolone, nor am I eating pork burritos, But

1:54:16

The, the sensitivity will vary.

1:54:18

And you can kind of predict that sensitivity by how you react to creatine.

1:54:21

If you're somebody that takes low doses of creatine, which many people do and experience hair loss, chances are when you take tumeric, you're going to see a reduction in DHT.

1:54:29

It means that your five alpha reductase system and or this interaction between tumeric and the androgen receptor are for whatever reason, more sensitive and you, some people take tumeric and feel perfectly fine.

1:54:40

I noticed a, an immediate blunting of all the good stuff.

1:54:45

Let's say that DHT and testosterone do when I take even a minimum of tumeric.

1:54:51

Now that doesn't mean I can't have a little bit of tumeric and a drink like a juice drink or something, but dosing tumeric is not something that I do or that I recommend for people.

1:54:59

Now, women do make a little bit of DHT.

1:55:02

It might be a whole different story with them, but I, I think for men, you probably just want to do the experiment.

1:55:07

It's quickly reversible. If you stop taking tumeric, so you could evaluate this, some people will be fine, but you could do a blood test.

1:55:13

You could do it. Subjectively Is

1:55:15

a Finasteride Propecia that is often used for mitigating hair loss.

1:55:20

That is, I think it's a five alpha reductase inhibitor.

1:55:25

Would that also have the effect of decreasing DHT levels?

1:55:30

I want to say their anecdotal reports and people, please do your own homework, go to go to pub med and do some research.

1:55:37

But I want to say that least among strength athletes that I've heard anecdotal reports of Propecia use correlating to decreases in strength gains for male athletes.

1:55:50

Yeah, absolutely. And it certainly can reduce DHT levels.

1:55:54

Certainly more for those that are sensitive to it, just to underscore how powerful DHT is.

1:55:59

We have what are called primary and secondary sex characteristics, secondary sex characteristics.

1:56:04

So like body hair deepening the voice, et cetera.

1:56:06

But the primary characteristics like the presence of a penis or not, and this is independent of gender.

1:56:11

This is just biological sex. It's encoded by the Y chromosome.

1:56:14

That's entirely controlled by DHT during development and masculinization of the brain is a separate pathway.

1:56:21

But there's this phenomenon that I think is in the Dominican Republic, a genetic disruption in some of these pathways and there that people can look this up.

1:56:29

The so-called whoever dosas. This is a famous story in endocrinology of children that look female at birth by genitalia.

1:56:36

And then because of a surge in DHT later, they literally sprout a penis at about and testicles descend at about age 12, whether doses, wow.

1:56:46

And there's a whole story there.

1:56:49

It actually was part of the story that helped neuroendocrinologist and developmental biologists understand the role of five alpha reductase in testosterone's conversion to DHD fascinating biology.

1:57:01

They're much too much to go into now in detail, but you'd be, people can look it up online.

1:57:05

DHT is powerful in development and it's powerful throughout the lifespan.

1:57:09

So you want to keep levels of DHT appropriately high, but don't take nandrolone if you're sprinting in the Olympics.

1:57:16

So that's not the way to get your nandrolone is not the way to get your DHT.

1:57:20

Yeah, Yeah, yeah. Even if you do get it through, through anabolic piggies, just like there's so many more cost-effective ways to make pigs grow DECA drabble and injections is probably not high on the list.

1:57:35

Natty menus, right. Menus that are like, if you're Olympic athlete, please just prepare your own food.

1:57:40

Yeah, Yeah, yeah, exactly.

1:57:42

So, so many directions to go here.

1:57:45

It makes me wonder also, if anyone has looked at turmeric or curcumin or whatever, the actual compound is responsible for this DHD inhibition, whether it's via five alpha reductase or otherwise on pregnancy and birth gender, I'm wondering if that would have any effect.

1:58:03

If DHT is suppressed in a woman who is pregnant, if that would have any effect on birth gender.

1:58:10

Yeah. That's a topic that I don't think the experiments ever been done, but my postdoc advisor, Ben Barris was transgendered.

1:58:16

And it's an interesting story briefly.

1:58:19

He was an identical twin.

1:58:21

He from a very early age, he felt entirely uncomfortable in a female body.

1:58:28

He knew he wanted to be male from a very young age, long before puberty.

1:58:31

His sister who I've I've interacted with as well is perfectly happy.

1:58:35

Being a woman enjoys being a woman and they're identical twins and their was actually treated with an androgenic drug during pregnancy then unfortunately passed away of pancreatic cancer.

1:58:47

A few years ago, he was an incredibly accomplished neuroscientist and physician.

1:58:51

His name is Barris B a R R E S.

1:58:54

There are a number of obituaries. I wrote one for nature that describes his, his life and in his transition and some of the biology, but nonetheless Ben and I spent about a year before he died.

1:59:06

I recorded a lot of conversations with Ben that I haven't released yet talking about what it was like to be a girl, what it was like to be a woman, what it was like to be a man later in life, just as I is our close friend of mine.

1:59:18

I want to understand that. And he described that this was an immediate effect.

1:59:25

As soon as he knew there was a difference between boys and girls.

1:59:27

He knew that he was in the wrong body. He likened it to, if you woke up tomorrow and you were in a gorilla's body, that's how uncomfortable it was knowing that that's how he described it.

1:59:38

And he thought that perhaps, you know, this early intergenic drug treatment, might've shaped his brain differently than his sister somehow.

1:59:46

Hm. Raises so many, so many interesting questions about, you know, phytoestrogens or soon as these Xeno estrogens and the environmental inputs that could affect that entire biochemical cocktail to different different outputs testosterone.

2:00:05

So we've talked a little bit about DHT.

2:00:07

There's a Goldilocks range depending on your gender and your objectives for testosterone.

2:00:13

Are there any particular supplements that you use to, I hesitate to use this word because it's so goal dependent, but optimize your testosterone or DHT levels or reduce sex hormone binding globulin or whatever.

2:00:28

If you're sort of toying with your androgens, how do you like to do it?

2:00:35

Optimizing and or understanding?

2:00:37

Testosterone, I think is vital for men and women because it's so powerful.

2:00:41

Obviously get your sleep right.

2:00:44

That's an important one. And you do that through.

2:00:45

So that's an indirect effect.

2:00:47

Stress keeps stress chronic stress to a minimum.

2:00:50

That's an indirect effect, train hard, but not too long.

2:00:52

That's an indirect effect. Mostly in the supplementation space.

2:00:56

There are two things that have worked very well for me.

2:01:00

And that I've recommended to a number of people that have worked well for them.

2:01:04

And those two things are tone got Ollie, which at 400 milligrams per day is thought to reduce sex hormone binding globulin.

2:01:15

Because of, for those that don't know, testosterone can exist in a freer bound form.

2:01:18

People hear binding globulins and they bind up testosterone, prevent free testosterone.

2:01:23

They think this is terrible, but actually albumin and sex hormone binding globulin are wonderful because they ensure that whatever testosterone you make will be delivered to your tissues over a long period of time and different tissues need different amounts of testosterone.

2:01:35

And so you don't want to plummet hormone binding globulin, but Tonga Ollie either through reducing sex hormone binding globulin, or through direct effects on increasing androgen release will increase your testosterone.

2:01:51

Now the way to explore this, and I'm not saying anyone should do this, you definitely want to work with your physician, but the way to explore this as 400 milligrams per day taken once per day, early in the day, because it can have a little bit of a stimulant effect and make you more alert that works well.

2:02:09

It doesn't need to be taken chronically.

2:02:10

It tends to work better as you get into the second and third month of use.

2:02:14

And I don't see any reason to cycle it unless somehow something's, you know, spikes on your liver enzymes or something.

2:02:21

The other supplement that is quite useful is for doji aggressiveness for dojo.

2:02:28

Aggressiveness is one of these plant alkaloids that I think it's, it comes from a Nigerian shrub.

2:02:33

I might have that wrong, but the dojo aggressiveness acts as a routinizing hormone mimic.

2:02:39

So it actually stimulates the testes to produce more testosterone.

2:02:44

So It's like HCG.

2:02:45

It's like a, it's a Bit

2:02:47

like HCG, but it, for whatever reason, it doesn't seem to increase estrogen, which is unique because HTG will increase estrogen.

2:02:55

Now, just anecdotally, I started using those in combination.

2:03:00

So it's 400 milligrams of Tonga Ali.

2:03:02

I have no relationship to the company so I can mention where I get it from.

2:03:06

Although I hope they don't sell out as a co, they will sell out as a consequences.

2:03:09

A Solaray makes a good version of this.

2:03:12

Sometimes these things are packaged in with other things, but solar has a pure form.

2:03:16

And then for doji aggressiveness, I think it's herbal elixirs makes an, a dojo aggressiveness.

2:03:21

And some people make the mistake of taking far too much for dojo aggressiveness.

2:03:25

I think on the bottle, they recommend three, two to three times a day, 1, 425 milligram capsule I believe is more than sufficient.

2:03:34

And anecdotally for me, what this did is that it increased my total testosterone by about 200 points.

2:03:41

So I fell kind of in the middle of the range.

2:03:44

I was neither high nor low. I was at about 600 hovering, somewhere around 600, these two supplements consistently bring it up into the high sevens or low eights, which is in the direction that I wanted to go.

2:03:56

Do you think for dojo aggressiveness, if it is luteinizing hormone, similar, meaning it's a mimic of sorts.

2:04:05

Do you think that would have any, I guess it probably would have a sort of down-regulating effect on endogenous production of LH?

2:04:16

Well, what's interesting is when I've done my blood work twice a year, at least for me, it did not downregulate LH, which is nice because things like HCG definitely would downregulate LH people who take testosterone cypionate, you know, T so-called TRT or similar, we'll see a downregulation and luteinizing hormone.

2:04:34

So for Docia and Tonga Ali, I mentioned because there's sort of an intermediate between doing nothing with respect to supplements or taking things that don't really work.

2:04:44

There are a lot of those out there or taking the full plunge into TRT.

2:04:49

And I'll just mention if I, if I may about TRT, there's a lot of interest and excitement in TRT.

2:04:54

They now even have what's called sports TRT, which is not.

2:05:00

And just for people who don't have the context, if I'm not sure if you, if you already kind of named it out, but testosterone replacement therapy, TRT what's what's sports TRT is this like med med spa type stuff.

2:05:14

Yeah. So people were probably wondering, wait, you're a neurobiologist.

2:05:16

Why do you know so much about this stuff? Well, I have the good fortune of doing work with various high-performing communities.

2:05:22

And there's just a lot of discussion around hormone and neural augmentation.

2:05:27

And so I'm not making recommendations.

2:05:29

I, what I generally do with those communities and what I'm doing now is point people to the fact that there, there are things that lie somewhere between doing nothing and going the, the prescription drug route, eating pork burritos.

2:05:42

Yeah, exactly, exactly.

2:05:44

In the realm of TRT, testosterone replacement therapy, the typical dosages that people use are 160 to 200 milligrams a week, but the way it's administered doesn't match the biology.

2:05:58

I think this is a serious problem that needs to be dealt with.

2:06:00

Typically, if you get a prescription, you'll go in, they'll give you one injection of anywhere from 160 to 200 milligrams.

2:06:06

And then you go back two weeks later and you get another injection.

2:06:09

The testes normally make anywhere from about five to 10 milligrams of testosterone a day.

2:06:15

So if you're taking 160 milligrams of testosterone on one day, you're going to set in motion, all sorts of cascades of aromization industry, gen conversion, into DHT that you might feel terrible then great, four days later.

2:06:30

And then so, so two weeks later, the way people are doing this now more intelligently is to do their injections at home, either into subcutaneously or into muscle and every third or fourth day to take a low dose of maybe 40 milligrams and to dose it more evenly because these long lasting forms like Sipion eight do release over time.

2:06:51

But sports TRT is this intermediate that's been created on the internet where people are neither doing testosterone replacement therapy to get levels up to normal or high, normal, nor are they doing what the gym rats called blasting.

2:07:05

They're not taking three, four or 500, they're taking 200 a week or 300 a week.

2:07:11

And the amount of self-directed pharmacology that's happening out there is pretty incredible.

2:07:17

And like, I don't pass judgment everybody, it's your life to live, but there are a lot of horror stories too.

2:07:23

You can really mess yourself up by getting androgen levels too high.

2:07:27

I'm a fan of gently moving into the supplementation space for this, seeing how it works, doing blood test.

2:07:35

And then if people want to do TRT over time, that certainly there, right.

2:07:39

That's not my place to judge and you need to, you need a prescription anyway.

2:07:42

Yeah. I'll talk to it. Yeah. And just a couple of additional thoughts on all of this stuff.

2:07:47

Well, first the lower dose, higher frequency regimen can also be applied to too many things, right?

2:07:55

Growth hormone would be another example from the same sort of portfolio of interventions slash augmentations that a lot of folks would use.

2:08:03

And separately, I would say, and please, please feel free to correct me or fact check on this.

2:08:09

But whether you're eating pork burritos, injecting yourself with anabolics of different types or eating deer, antler velvet or whatever the latest fad is that people claim increases testosterone.

2:08:24

If you dramatically increase your testosterone levels, if you are not taking an anti Roma taste.

2:08:30

So you are also going to increase your estrogen levels, even though it depends on the anabolic.

2:08:36

Obviously nandrolone is very different from different types of testosterone.

2:08:39

So on which, you know, some are more anabolic, some are more androgenic, but if you suddenly wall up yourself with much higher levels of testosterone, you are also going to a portion of that will be converted to estrogen.

2:08:52

And so it's just something to be aware of.

2:08:54

It's very hard to get a biological free lunch.

2:08:58

And

2:08:58

if

2:08:58

you're,

2:08:58

if

2:08:58

you're

2:08:58

feeding

2:08:58

yourself

2:08:58

a

2:08:58

bunch

2:08:58

of

2:08:58

stuff

2:08:58

and

2:08:58

your

2:08:58

testes

2:08:58

like

2:08:58

the

2:08:58

Siberian,

2:08:58

what

2:08:58

were

2:08:58

they,

2:09:07

Rats and hamsters.

2:09:11

If your, if your balls go from whatever you're comfortable, ball diameter is down to like raisins, you may require post cycle therapy, PCT, various drugs to successfully off-ramp from these types of interventions in less like some powerlifters, you're just going to be loaded all year round 365, 24 7, which is obviously your, your choice.

2:09:36

If you want to do something like that, but suffice, I'm glad you're good.

2:09:40

Yeah. Good idea. To get medical, medical supervision for all these things.

2:09:43

Definitely. And, and along those lines, I should just mention, well, I will say that tends to have the opposite effect on the testicles.

2:09:49

It actually will cause a fairly, not pronounced, but a increases testicle size.

2:09:54

That's a pretty strong effect or immediate effect of

2:09:58

The other thing is that right now there's a lot of excitement about peptides.

2:10:01

People are like, oh, the so-called secretes dogs.

2:10:04

It sounds like synagogue, but it's secreted God.

2:10:06

Whereas these are like not, not taking growth hormone, but taking peptides that promote growth, hormone release.

2:10:12

And then people are taking, you know, gastric peptide this, and here's the deal.

2:10:16

Things that make us feel more vital like testosterone, DHT growth hormone generally will shorten your life.

2:10:26

I know that's a bit of a controversial statement, but what, but if you step back and use this, just ask yourself, what is the most vital, energetic phase of your life?

2:10:36

It's puberty. When all these hormones are really high and puberty is the most rapid period of aging that any of us go through.

2:10:44

I was talking about this recently with a longevity researcher and I, and it's kind of interesting that all the longevity, the attempts at increasing lifespan, or like starving yourself, which is catabolic, reducing blood sugar, which is catabolic.

2:10:57

And that's on the opposite side of all these things like testosterone, which is anabolic insulin, which is anabolic growth hormone, which is anabolic.

2:11:05

And so anibolism sounds like a great thing.

2:11:08

Although it does sound remarkably similar to cannibalism, but growth and vitality, libido, strength, et cetera, that all sounds wonderful.

2:11:17

And in its proper form and context is wonderful.

2:11:19

But the reason why I think we see people dying early, who do a lot of growth hormone and testosterone is because they've effectively created a third and fourth round of puberty.

2:11:30

You're accelerating aging.

2:11:31

And so I think vitality and longevity always have to be balanced with one another.

2:11:38

Totally. And we could go for hours just on this one, topic, one other cautionary note.

2:11:44

Well, two actually number one, unless you're type one diabetic, don't inject insulin.

2:11:49

There are athletes who do this, but you can very easily kill yourself.

2:11:52

The second is, if you're taking a lot of growth agents, some of them are not selective to skeletal muscle tissue.

2:12:00

And you may, as a male end up looking like you're in your second trimester from enlarged organs.

2:12:07

And guess what, when you get off of those drugs, your organs don't automatically resume their smaller size.

2:12:12

This is also why certain baseball players and so on have gone up multiple helmets sizes.

2:12:18

It's not from pork burritos.

2:12:19

Those effects are durable.

2:12:21

You can't just hit undo on those things.

2:12:24

So very, very good points pays to be cautious.

2:12:27

All right. So to a few other things, cognitive enhancement or cognitive boosting supplements, much like the testosterone playing field, there's a clown car full of ridiculous propositions.

2:12:42

There are, of course then the prescription and medical route, where there are certain things that'll help.

2:12:50

Some things like nicotine can be tremendously effective, but come with some possible downsides associated.

2:12:57

Do you have any particular thoughts on cognitive enhancement or how you think about that specifically on the pharmacological supplement side?

2:13:07

I know there are many other things that we can also talk about.

2:13:10

Yeah. I'm glad you mentioned that many other things.

2:13:12

I won't list them out again, but I do believe that the most powerful nootropic and cognitive support is going to come from quality sleep and a hundred percent, you know, so it's night and day on the pharmacologic side.

2:13:25

I, I think alpha GPC has real effects that are supported by quality peer reviewed studies, including some studies looking at offsetting age-related cognitive decline.

2:13:37

So generally it comes in capsule form of 300 milligrams or so I think taken occasionally or more than occasionally provide it's fairly early in the day.

2:13:48

It does increase focus without increasing the kind of sympathetic arm or the nervous system.

2:13:53

In other words, without increasing arousal and alertness too much.

2:13:57

So I do think alpha GPC is a useful supplement and I use it from time to time if I've slept well, I don't take it.

2:14:05

If I really want to push a workout hard or a work session, a writing session or data analysis session hard, I'll take 300 milligrams of that and drink a couple of espresso or drink some Mati and some water stay hydrated.

2:14:21

Hydration is a big one for cognitive function.

2:14:23

And it's one that people often overlook.

2:14:24

But the simple rule is that this is what I call the Galpin equation.

2:14:29

Cause Andy Galpin, who's a great exercise.

2:14:31

Physiologist came up with this for physical work, but it turns out to work for cognitive work too, which is that basically your body weight in pounds divided by 30.

2:14:38

We'll give you the number of ounces of water that you should drink about every 20 minutes when exercising or doing mental work might seem like a lot.

2:14:49

There might be an extra trip to the bathroom or two, but it's worth it.

2:14:52

Dehydration is a subtle, but very pernicious creep where you start having hard time focusing your eyes.

2:14:59

You, you just feel like you want to go to sleep.

2:15:01

That hydration factor is real.

2:15:03

So drink plenty of fluids, especially if you're ingesting caffeine, which of course is, is diuretic.

2:15:09

My personal favorite vehicle for caffeine remains Yerba Mata.

2:15:14

I just absolutely adore the effects of your Rahmati.

2:15:19

I'm not saying it's for everyone, but you have the caffeine and I might be getting the pronunciation off.

2:15:24

You also have a belief Seattle saline, which you would find in green tea and theobromine which you would also find and say dark chocolate side note trivia for folks Theo bromine from Theo as in theosophy Theo, Broma food of the gods.

2:15:39

So that's kind of fun.

2:15:40

Yeah, but the pharmacokinetics of those are all different.

2:15:44

So unlike coffee, which I, I have a love, hate relationship with because I metabolize it so quickly that I get this, this sort of Snickers bar sugar, high of caffeine for a very short time, 20 or 30 minutes.

2:15:59

And then my baseline of sort of subjective perceived energy is lower than when I started.

2:16:05

So what happens then? I become a crack head who drinks, you know, eight cups of coffee a day, not so with Yerba latte, especially when you're kind of titrating it in, in the way that they would consume it in a place like Argentina or UWA, where you're just kind of sipping it slowly, Great

2:16:22

stuff. I found a brand that I don't have any relation to them, but I found one that I particularly like it's has a weird name.

2:16:28

It's Anna Park, It's an organic and a part of a motto.

2:16:31

I don't know who Anna is or her park or maybe her name is Anna Park, but it's nice.

2:16:36

It has the right amount of that tobacco flavor, but it's not burnt to the point of feeling kind of overwhelming.

2:16:42

The other thing about caffeine, that's kind of interesting is that most people would benefit from waiting 90 minutes to two hours after waking to ingest their caffeine, the way caffeine interacts with the adenosine receptors.

2:16:54

Remember you get sleepy because of time of day with that sort of whole circadian clock mechanism, but also because of the buildup of a dentist seen in your system, that's the sleepiness factor really?

2:17:04

And when you wake up in the morning, if you immediately compete out any residual adenosine, you lose the benefit of that cortisol pulse, essentially clearing out the rest of the adenosine.

2:17:16

And so a lot of people, despite the pain of having to do this the first day or two, feel much better throughout the day, less of that cracked out kind of rise and crash feeling on caffeine.

2:17:29

If they delay their coffee or Mati for about 90 minutes to two hours after waking, Oh,

2:17:35

that's great to know, side note for people who may want to do some, some further research and reading into caffeine.

2:17:41

The name Roland Griffiths has come up multiple times on this podcast.

2:17:46

He's an incredible scientist and researcher based at Johns Hopkins, who is the, he is one of the most, I would say steamed researchers alongside Saint Matt Johnson.

2:17:57

Roland has just been at it for longer with respect to siliciden and psychedelic.

2:18:03

So he's associated with that. But prior to psychedelics, he was one of the world's foremost experts in caffeine metabolism.

2:18:09

And so he is, he has published and performed studies related to caffeine that are intensely interesting.

2:18:18

So for people who want to dig deeper into that, Roland is Roland.

2:18:22

Griffiths is a great resource.

2:18:23

You know, one thing I've been wondering because there are drugs that you can use to counteract other drugs, right?

2:18:30

So if you go to Bellevue and you're at the psych, ER, and someone comes in just high out of their mind on cocaine, right?

2:18:40

There are medications that could be given to try to take them down a notch or two or three or 10, the caledal, or I'm not sure if that's used any longer, but there, there are many different drugs that can be used in the case of caffeine.

2:18:54

Let's just say someone named Jim Barris, just for sake of argument is working on his laptop at a restaurant and said, restaurant has excellent service, which means they also have the never-ending cup of coffee.

2:19:08

And so before he knows that he's had five cups of coffee, even though he only ordered one coffee, is there a way to reverse or counteract the effects of caffeine on a dentist seen such that you can actually get to sleep because if you hit the golf ball and you're like, oh fuck looking at the half-life of caffeine, there's no way I'm getting to sleep until like three in the morning.

2:19:32

Is there any way to address that?

2:19:35

Or is it just fait accompli and you're more or less Yeah,

2:19:39

one direct and two indirect.

2:19:41

The direct way to do that is increase your glucose.

2:19:44

You know, the whole notion that you can soak it up by eating some bread, you will see a blunting of the stimulant effect.

2:19:50

Now, whether or not that's also due to some, I don't know, increase in serotonin or something from the carbohydrate isn't clear, but yeah, you could have a bagel or two or whatever it is that you're compatible carbohydrate.

2:20:02

These days, carbohydrates are such a complicated thing.

2:20:05

For most people. I like carbohydrates, especially late in the day.

2:20:07

I do the either fast and go low-carb no-carb during the day, because that lets me focus and that's so meat and salad during the day or not eating for portions day.

2:20:16

And then at night I eat pasta and rice and I eat very little protein sleep like a baby.

2:20:20

That's what works. But the other way is to take theonine.

2:20:24

So before we were talking about theonine in reference to pre sleep supplementation, 30 or 60 minutes before sleep, but a hundred to 200 milligrams of theonine, we'll take the jitters out of a caffeine experience.

2:20:38

And in fact, so much so that a lot of energy drinks now are starting to include the as an attempt to get you to ingest more of those energy drinks, because they understand that at some point people hit threshold and they feel so wide-eyed and wired that they're not going to consume more.

2:20:53

So they they're tricking you this way.

2:20:55

And it does indeed work. The other thing is if you ever really need to sleep, I mean, again, be cautious do what's compatible with your physician's advice, but Gabba, you know, you can buy GABA and glycine in capsule form.

2:21:09

So a gram of GABAA gram of glycine in combination, that's more of a heavy hit over the head, but if you're having a hard time getting to sleep that can help.

2:21:20

I don't recommend people take those chronically because GABA of course is a neurotransmitter.

2:21:23

And I don't believe really in taking things that are very close to the actual thing that you're trying to manipulate.

2:21:29

For instance, I'm not a fan of taking L-DOPA why would I do that?

2:21:33

I don't have Parkinson's, but people will take Macuna Purina, which is, you know, essentially 99% of L-DOPA and you'll get really, really elevated, but then you'll really crash for a day or two.

2:21:45

So I think that pulling on the marionette strings a little bit from a distance is better than taking the specific compound that you're trying to replace, unless there's a clinical need.

2:21:56

Of course, One more topic.

2:21:57

And since we're at about two hours and 30 we'll, we'll wrap up in just a little bit, but the vagus nerve, what is the vagus nerve?

2:22:07

What is the latest and greatest? Why is it of interest?

2:22:11

Yeah, so the vagus nerve is a nerve network.

2:22:13

It's many nerves. It could even be thought of as its own major branch of the peripheral nervous system.

2:22:19

It comes out of the brain basically and connects to all the organs of the body.

2:22:23

And this is the pathway By

2:22:25

which a mental state can influence our digestion, our heart rate, our breathing.

2:22:30

We talked to her Earlier,

2:22:32

but HRV heart rate variability, the Vegas is an important component to the slowing down of the heart rate.

2:22:38

We exhale. It's a very important pathway and it's binding Directional.

2:22:42

So the organs of the body that I just mentioned, the lungs, The

2:22:45

gut, the heart, et cetera, the spleen, they also send nerve connections back to the brain.

2:22:50

And there's been a lot of interest in the Vegas as a purely calming system.

2:22:55

And that's simply not true.

2:22:57

The medical textbooks call it appropriately, cranial nerve 10 it's in there, Parasympathetic

2:23:01

arm of the nervous system, which suggests that it's all calming, but actually Really

2:23:05

it's not, it has branches of it that are kind of stimulating as well.

2:23:09

So in the kind of wellness and self-help community, you hear, oh yeah, You

2:23:14

should do this thing of rubbing in front of your ears.

2:23:16

That's a branch of the vagus that calms you down or stimulate the Vegas to calm down now in neuroscience laboratories.

2:23:22

And even in some human neurosurgery laboratories, the way that you get people more alert.

2:23:27

In fact, form Of depression treatment is to stimulate the Vegas and it makes people more alert and more positive and excited.

2:23:34

So vagal stimulation can easily cause increases in alertness.

2:23:38

How do they do the stimulation?

2:23:40

This is a beautiful story.

2:23:42

A colleague of mine, perhaps in least to my mind, Most

2:23:45

impressive. Neurobiologists I know a guy by the name of Karl Deisseroth.

2:23:47

He invented, discovered and invented channelrhodopsin, which are these from algae, Essentially

2:23:53

that are light sensitive, clone the genes, Put

2:23:56

those genes into neurons. You have to do this by viral injection.

2:23:59

And then you have a little blue light diode that will allow you to stimulate just those neurons locally.

2:24:03

Carl's a psychiatrist, a bioengineer, and a neurobiologist operating at the very high Level.

2:24:09

Actually there's a book that he just published that I'm listening to now that is it's just Can

2:24:15

only be described as beautiful. It's a description of the landscape of psychiatry and his attempts to build tools that are better than drugs to manipulate the nervous system Projections.

2:24:24

And it's a beautiful read.

2:24:27

You'll learn a ton of neuroscience.

2:24:29

Carl is well on his way to win every big prize in science.

2:24:33

He's got all of them right now, except the last one.

2:24:36

And I'm not on the committee that votes for those, but he's remarkable.

2:24:40

Also has Children

2:24:42

happily married. I mean, it's like one of these, his wife is a phenomenal scientist and physician.

2:24:46

These people are as one of the reasons I like being at Stanford is because the mean is so very high, but Carl shifts the mean like he's that dot way out there in any event, Carl, there's a beautiful article That

2:24:57

I can reference, send you the link to in the new Yorker where Carl is sitting there talking with his patient and she has suicidal depression and she's describing her lack of desire to live.

2:25:09

And then he cranks up the intensity on the stimulation of the Vegas.

2:25:14

And in real time, she starts describing how she acts Actually

2:25:18

would be interested in applying for a couple of jobs this year.

2:25:20

This is happening in the order of, by stimulation of the Vegas.

2:25:24

What is the machine? What is it actually, how does it connect to her that one, an implanted electrical stimulation device that's placed probably on there many branches of the Vegas and so on a branch that isn't going to impact breathing.

2:25:37

Sometimes people will have challenges with swallowing.

2:25:39

So there are problems doing the Carl.

2:25:42

A big part of his mission is to create very small light diodes that can stimulate nerves without the need to inject viruses and things of that sort.

2:25:51

So that I think at a time, not too far from now, thanks to his work and the work of other bioengineers, we are going to be able to stimulate, for instance, just the serotonin neurons in the Raffa that lead to coping.

2:26:04

This is a well-known phenomenon.

2:26:06

Whereas when you take Prozac Zoloft or one of these other drugs that will stimulate those neurons, but will also stimulate the serotonin receptors on the spinal neurons that control the sexual response.

2:26:16

And that's why they have sex. Sure. Side effects.

2:26:18

So more precision is coming.

2:26:21

So as it relates to Vegas, the other way in which the Vegas is stimulating is something that we do quite often.

2:26:28

We have neurons in our gut that we all hear about the gut brain axis.

2:26:32

And people say, what's your second brain, but very similar.

2:26:35

Does anyone actually describe how the second brain actually impacts the other?

2:26:38

And the simple way to put this as we have these neurons that live in the mucosal lining of our gut and those neurons sense, three things, they sense fatty acids.

2:26:48

So they like fat.

2:26:49

They amino acids.

2:26:51

They love that umami flavor and they love amino acids because that's vital to protein, repair, metallic, awesome, etc.

2:26:57

Protein synthesis, excuse me.

2:26:58

And they like sugar. And when you eat something that has fatty acids, amino acids, or sugar, these neurons send a signal.

2:27:08

They're part of the vagus nerve up to a little cluster of neurons, your neck called the NoDoz ganglia and no D O se and the NoDoz ganglia then stimulates your deep brain centers to release dopamine.

2:27:20

And the amazing thing about this, these are data from a guy named Diego Boris at duke university.

2:27:24

The amazing thing about this system is that even if you numb the mouth, even if you just Gavaskar a person or an animal and put the substances into the stomach, you will seek more of these foods.

2:27:37

And so you're actually seeking sugar, amino acids, and fat more when you ingest those foods independent and of how they taste.

2:27:46

And so this has a whole set of implications for hidden sugars and the fact that so many of the foods we eat, we just find ourselves eating more of them.

2:27:54

We think this doesn't even take it.

2:27:56

I don't even know why I'm eating this it's because these neurons in your gut are stimulating dopamine release.

2:28:00

And as we talked about before for dopamine, isn't a molecule pleasure.

2:28:04

It's a molecule of making you want to do whatever led to dope for me in release.

2:28:08

Yeah. The molecule of more the molecule more so the Vegas is multifaceted and we will soon hopefully subdivide it into some more meaningful pathways I don't like to on anyone Else's

2:28:22

work. But I do think that most of what you read out there about the Vegas and what it does and various theories about it are partial truths to total nonsense, but they are partial trues to total nonsense that we're grounded in the biology as we understood it at the time.

2:28:36

And just a lot more has been understood in the last 10 years or so.

2:28:39

So no disrespect to those people, but it's time for a revision, Maybe

2:28:44

two or three more questions, then we'll, we'll go get some food or something along those lines.

2:28:50

The first is what books have you gifted the most to other people?

2:28:55

Or are there any books that come to mind that you've gifted often to other people?

2:29:01

I love poetry. And it's almost cliche now to say this because so many people like his work, but I think David White's work is just beautiful and is a wonderful kind of entry point to, to poetry.

2:29:12

I'm also a big Wendell Berry fan has written a lot about farming and the natural world, and I've never met him, but I'm a huge Wendell Berry fan.

2:29:21

So I'll sometimes give Wendell Berry books as gifts.

2:29:24

The book that I I think is perhaps at least to me, the most beautiful book of all is longitude by Dava Sobel about the history of the discovery of timekeeping at ocean, which is not a trivial problem to solve.

2:29:40

And it's just a beautiful story of how scientists or in this case, a particular scientist merged the quest for a technology with a scientific problem with adventure and going out on boats and, you know, risking one's life for the sake of science is something that resonates with me a bit.

2:29:59

It's a beautiful short book, and it's very accessible to anybody, whether or not you have a background in science or not.

2:30:05

And she's an absolutely wonderful writer.

2:30:08

And so that's the one I give to most often, Is

2:30:11

there a particular David White book or starting point that you might recommend?

2:30:17

You know, I own several of his books, but I confess that I I'm forgetting the titles now, you know, what's interesting about David White is that his poetry is best consumed by listening to him read it because he does this thing of repeating things twice.

2:30:32

And his cadence is so impressive.

2:30:34

And so I would, even though I loads to kind of push people toward online Dubai, his books, but I would suggest just going online and listening to a YouTube video or watching YouTube video of David reading, one of his poems, he's onto something.

2:30:49

The thing about poetry. That's so fascinating to me, it's the same reason why I love anything sung by Bob Dylan or Joe Strummer is that the words don't necessarily make sense in the pure cognitive landscape.

2:31:01

They're tapping into some sort of deeper layer of the nervous system that defies the normal structure of sentences and thoughts.

2:31:08

And so I think they good poets are accessing the subconscious and it has nothing to do with rhyming.

2:31:13

It has to do with accessing some layer of neurobiology that we just don't have a name for Andrew.

2:31:20

This question is sometimes a complete dead end, and I'll take the blame for that, if it is, but just to, just to go fishing and see what we catch here.

2:31:28

If you could put anything on a gigantic billboard, metaphorically speaking, to get a message out, quote an image, a word could be anything, a quote from someone else, anything at all to billions of people.

2:31:43

What might you put on that billboard?

2:31:47

Well, assuming this is a big billboard, I could probably squeeze two things on there, but I would diminish the impact of either one.

2:31:52

So it's so simple, but it's the most use at least has been the most useful thing in life to me, which is credit goes to the Oracle, which is know thyself.

2:32:02

If there's one thing that's a really useful pursuit is to take a really good stock of what you've come into the world with and where you happen to be at present.

2:32:12

Get really honest about that with yourself and in doing that, it illuminates the path to filling in the gaps and improving oneself and knowing thyself is a dynamic process and the answers to knowing myself and what that is, will change over time.

2:32:29

But that is the question that I think everybody, as soon as we are able to should be asking ourselves and constantly updating No

2:32:38

that I saw what was second pick.

2:32:39

You can put it on the other side of the billboard.

2:32:42

Yeah. The other one was far weaker as the one I think, but use the body to control the mind.

2:32:48

I really worry about the current state of the world where people are so unable to regulate their autonomic nervous system.

2:32:57

They're stressed, they're angry, they're pissed.

2:32:58

And look, I suffer from this to someone sometimes comment on whatever.

2:33:02

I'm mostly on Instagram, but sometimes on Twitter.

2:33:05

And I noticed all this anger and stuff, and you start getting pulled into it from time to time.

2:33:08

I, I regulate my behavior, but I don't respond, but we're all subject to this, but almost all harm, almost all self-harm and unfortunate things in life are the consequences of a poorly regulated autonomic nervous system.

2:33:24

We say the wrong thing. We, we do the wrong thing.

2:33:26

We're impulsive, et cetera.

2:33:28

And I think controlling the autonomic nervous system is simple in one sense and challenging.

2:33:35

And the other simple in the sense that the tools exist, I do believe that respiration and vision are, are the two ways to control the autonomic nervous system in real time, the best ones.

2:33:45

And at the same time, it's, it's very hard to do so we have to remind ourselves.

2:33:50

That's why I'd want to put it on the billboard that when your mind isn't where you want it to be, use your body to control your mind.

2:33:59

I love that. Gonna use that on a long hike with the pooch a little later today, and we'll also include for everybody listening show notes, with links to various resources, all the resources that we've discussed.

2:34:15

So the yoga nidra, the various types of breath work.

2:34:19

I'll also add a name which is Leah Lagos'.

2:34:23

Dr. Leah Lagos' has done a lot of really good work looking at resonance training, using breath work for improving HRV.

2:34:30

Although improved HRV is really just a proxy for all of these other desirable outputs and effects in the world and in life.

2:34:39

So we'll include all of that in the show notes.

2:34:41

Andrew, we've covered a lot of ground.

2:34:42

Is there anything else that you would like to mention or say or point people to, and your request of the audience, anything at all that you'd like to add before we wrap up for today, We

2:34:57

mentioned some of the things at the beginning. You know, I teach neuroscience on Instagram at Huberman lab.

2:35:01

Those are resources, brief snippets, anywhere from one to three minutes about neuroscience, exciting papers.

2:35:07

I see a lot of tools, be wonderful if people want to check out the podcast and we cover a lot of topics, not just neuroscience.

2:35:14

And we batch those by month so that we do four or five episodes in one thing like hormones, and then move on to something else.

2:35:20

And I suppose one request would be, we have the saying in a laboratory, it's certainly not unique to laboratories, which is watch one, do one, teach one.

2:35:30

And what would be most gratifying for me would be if people find tools that they find useful and they, that they learn about them, that's the watch one part that they do them.

2:35:40

They apply them in their own life and modify them if you like.

2:35:43

And then I think the way the world works best, at least in my view is when people go on to teach those tools and attribution isn't required, I didn't, as I always say, you know, I wasn't consulted that the design phase and I don't know anyone else that was either.

2:35:56

So, you know, mother nature and deserves and biology deserve credit for all this.

2:36:00

And so if people would like to learn, practice and teach, I like to think that the world can improve by virtue of sharing of tools.

2:36:08

I love it. I dig it, man. And there are a number of places people can follow you and should check you out.

2:36:15

As you mentioned, the human lab podcast, human lab.com and human lab at human lab on Instagram and Twitter.

2:36:24

This has been so fun.

2:36:25

And I really appreciate all the time.

2:36:27

It's been a real pleasure spending time with you, Andrew.

2:36:30

And I look forward to many more conversations.

2:36:33

I have a feeling that people will want a round two.

2:36:36

So until then, thanks to you and thanks to Eric, Everyone

2:36:41

for tuning in, Hey guys, this is Tim again, just a few more things before you take off.

2:36:46

Number one, this is five bullet Friday.

2:36:49

Do you want to get a short email from me?

2:36:53

And would you enjoy getting a short email from me every Friday that provides a little more soul of fun before the weekend and five bullet Friday is a very short email where I share the coolest things I've found or that I've been pondering over the week.

2:37:06

That could include favorite new albums that I've discovered it could include gizmos and gadgets and all sorts of weird shit that I've somehow dug up in the, the world of the esoteric as I do.

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It could include favorite articles that I've read and that I've shared with my close friends, for instance.

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And it's very short. It's just a little tiny bite of goodness before you head off for the weekend.

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So if you want to receive that, check it out, just go to four hour work week.com.

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This podcast episode is brought to you by helix podcast episode is brought to you by Helix sleep. Sleep is super important to me in the last few years, I've come to conclude it is the end all be all that all good things, good mood, good performance, Sleep is super important to me in the last few years. I've come to conclude. It is the end all be all. That all good things, good mood, good performance, good. Everything seemed to stem from good good everything seem to stem from good sleep. So I've tried a lot to optimize So I've tried a lot to optimize, and it. I've tried pills and potions, all sorts of different I've tried pills, and potions, all sorts of different mattresses. You name you name it. And for the last few years I've been sleeping on a helix midnight Lux And for the last few years, I've been sleeping on a Helix midnight luxe mattress. I also have one in the guest bedroom and feedback from friends has always been I also have one in the guest bedroom and feedback from friends has always been fantastic. It's something that they comment It's something that they comment on. Helix Sleep, Has a quiz. It takes about two minutes to complete that matches your body type and sleep preferences to the perfect mattress for about two minutes to complete that matches your body type and sleep preferences to the perfect mattress for you. With helix, there's a specific mattress for each and every body that is your With Helix, there's a specific mattress for each and every body. That is your body. Also your Also taste. So let's say you sleep on your side and like a super soft bed, no So let's say you sleep on your side, and like a super soft bed. No problem. Or if you're back sleeper who likes a mattress that's as firm Iraq. They've got a mattress for you to helix with selected as the number one best overall mattress pick of 2020 by GQ magazine, wired, apartment therapy, and many others just go to helix, as a they've got a mattress for you too. Helix was selected as the number one best overall mattress pick of twenty twenty by GQ magazine, Wired, Apartment Therapy, and many others. Just go to helix sleep dot com slash Tim Take their two minute sleep quiz and they'll match you to a customized mattress that will give you the best sleep of your life. They have a ten year warranty and you get to try it out for one hundred nights risk free. They even pick it up from you if you don't love it. And now my dear listeners helix is offering up to $200 off of all mattress orders and two free [email protected] slash And now my dear listeners, Helix is offering up to two hundred dollars off of all mattress orders and two free pillows at helix sleep dot com slash Tim. These are not cheap pillows These are not cheap pillows either. So getting to for free is an upgraded so getting two for free is an upgraded deal. So that's up to two hundred dollars off and two free pillows at helix sleep dot com slash Tim. That's helix HELIX sleep dot com slash tim for up to two hundred dollars off. So check it out one more So check it out one more time. Helix, H E L I X Helix HELIX sleep dot com slash Tim. This episode is brought to you by gun. I have two thera guns, and they're worth their weight in I have two TheraGens and they're worth their weight in gold. I've been using them every single day, whether you're an elite athlete or just a regular person trying to get through your day, muscle pain and muscle tension are real I've been using them every single day. Whether you're an elite athlete or just a regular person trying to get through your day, muscle pain and muscle tension are real things. That's why I use the That's why I use the third gun. I use it at night. I use it after I use it after workouts. It is a handheld percussive therapy device that releases your deepest muscle It is a handheld, percussive therapy device that releases your deepest muscle tension. So for instance, at night, I might use it on the bottom of my So for instance, at night, I might use it on the bottom of my feet. It's helped with my plantar It's helped with my planter fasciitis. I will have my girlfriend use it up and down the middle of my back and I'll use it on her. It's an easy way for us to actually trade massages in It's an easy way for us to actually trade massages in and you can think of it. In fact, as massage reinvented on some level helps with performance, helps with recovery helps with just getting your back to feel better before in fact, as massager reinvented on some level. Helps with performance, Helps with recovery, helps with just getting your back to feel better before bed after you've been sitting for way too many hours. I love this thing. And the all new Gen four Theragon has a proprietary brushless motor that is surprisingly quiet. It's easy to It's easy to use and about as quiet as an electric toothbrush. It's pretty astonishing. And you really have to feel the TheraGund's signature power amplitude and effectiveness to believe it. It's one of my favorite gadgets in my house at this point. So I encourage you to check it So I encourage you to check it out. Try thera gun that's thera, T H E R a G U Try Theragon. That's Thera. N. There's no substitute for the gen four thera gun with an OLED There's no substitute for the Gen four Theragon with an OLED screen. That's O L E that's D. For those wondering that's organic light emitting diode screen, personalized therapy, gun app, and incredible combination of quiet and for those wondering, that's organic light emitting diode screen, personalized Theragon app, and an incredible combination of quiet and power. So go to Theragon dot com slash Tim right now and get your Gen four Theragon today or you can watch the videos on the site which show you all sorts of different ways to use it. A lot of runner, friends of mine used them on their it bands after long runs, there are a million ways to use lot of runner friends of mine use them on their IT bands after long runs. There are million ways to use it. And the gen fourth Oregon's start at just And the Gen four air guns start at just one hundred and ninety nine dollars I said I have two. I have the prime. And I also have the pro, which is like the super cat like version. My girlfriend loves the soft attachments on My girlfriend loves these soft attachments. On So check it out. Go to thiragon dot com slash Tim. One more one more time. Thera thiragon dot com slash Tim. Optimal. At this altitude, I can run flat out for a half mile before my head starts shaking. I answer your personal question? Lowboys and girls, ladies and germs. This is Tim Ferriss. Welcome to another episode of the Tim Ferriss show, where it is my job to interview world class performers from all different disciplines tease out the habits, routines, influences, life lessons, and so on that you can apply to your own lives. My guest today is Huberman, that's HUBERMANPHD. You can find them on Twitter and Instagram at Huberman Andrew is a neuroscientist and tenured professor in the Department of Neurobiology at Stanford University School of Medicine. He has made numerous important contributions to the fields of brain development, brain function, and neuroplasticity. Andrew is a McKnight Foundation and Pew Foundation Fellow and recipient of two thousand seventeen, Cogan, that Cogan, award for his discoveries in the study of vision, worked from the Laboratory at Stanford Medicine, has been consistently published in top journals, including Nature, Science, and Sell. Andrew is the host of Huberman Labnbsppodcast, which he launched in January of this year. The show aims to help viewers and listeners improve their health with science and science based tools. New episodes aired every Monday on YouTube and all podcast platforms. As mentioned, you can find him on Instagram and Twitter at hebrewmanlab. You can find him on the web at hebrewmanlab dot com. Andrew, many people have been trying to matchmaker for five or six years. And finally, here we are. Welcome to the show. Oh, thanks so much for having me here. Yes. We've crossed paths near misses for a long time, and it's great to finally sit down and chat. I thought I would start writing your wheelhouse and use a headline to introduce the subject of vision. Scientific American interview due not long ago, and they titled the piece, quote, vision and breathing, maybe the secrets to surviving twenty twenty. And, quote, So, breathing, I think for a lot of folks seem self evident. Stop that. You have a lot of problems on your hands. Or if you do it incorrectly, we can we can certainly dive into that. Later on. Vision I think will jump out is perhaps odd to a lot of folks. Why vision? Why is vision? Perhaps a secret or a key to surviving twenty twenty or any year for that matter. You know, so the vision and our visual system is perhaps the strongest lever by which we can shift our state of mind and body. And that might at first come as a surprise because we think a vision is this thing that we have to see colors and motion and recognized faces, etcetera. But the two little goodies in the front of our skull, our eyes, are actually part of our central nervous system. lot of people don't realize this, but your neural retina, the little light sensing piece of the eyes in the back of the eye kind of lines it like a pie crust. Are actually two pieces of your brain that were deliberately squeezed out during early development. So they're the only two pieces of your brain that are out side the cranial vault, as we say. And those little pieces of brain have an enormous impact on the state of the rest of your brain. So it's fair to say that what you see and how you view the world literally has an incredible impact on your state of mind. Respiration breathing also on your state of mind and body. But the reason is the following. Our visual system is not just for seeing objects shapes and colors, etcetera. Our eyes have two functions, so much in the same way that our ears are responsible for hearing, but also there's a balance mechanism in there. Our eyes are responsible for detecting shapes and colors, etcetera. But also for telling the rest of the brain, whether or not to be more alert or more relaxed. And the most fundamental way that our eyes do that is communicating time of day the presence or absence of sunlight to our central circadian clock and then the central circadian clock which is really just an aggregation of neurons communicates to the rest of the brain and body Whether or not, for instance, metabolism should be higher, metabolism should be low. Whether or not we should feel like moving or feel like lying down and not moving at all. But there are number of ways in which the visual system works on fast time scales to adjust our inner state. And one of the most simple ways that it does that is one that normally happens when we're stressed or relaxed, but we don't recognize it. So for instance, if we are very relaxed, our pupils change or the shape of our lens changes such that we actually have dilated vision, it. So for instance, if we are very relaxed, our pupils change or the shape of our lens changes such that we actually have dilated vision. We see the entire environment we're in, so called, panoramic vision. When we are stressed, or we are excited about something. The pupils dilate, the shape of our lens changes, literally the optics of our eye changes, and The information about the outside world that's delivered to our the rest of our brain and body changes. The aperture of our experience. Our entire experience shrinks. We get so called soda straw view of the world. We're looking through soda straws essentially when we are alert or stressed. And we've experienced this, but we don't normally notice it happening. So much like breathing, our experience of life, whether or not we're alert or stressed, excited, or calm, changes our patterns of breathing. We're all accustomed to that. Our breathing speeding up, we're holding our breath in anticipation. But as well our interstate drives changes in our visual system, the aperture of whether or not we see the big picture or we have a very contracted view of the world. But both those things. Breathing and vision also run-in reverse. Meaning, if we change our pattern of breathing, we change our inner state. If our state changes, our breathing changes, so it's reciprocal. It's bidirectional. Likewise, with vision, when we are excited or stressed, The aperture of our visual window shrinks. We get that soda straw view of the world. When we are relaxed, the aperture of our vision expands. But as well, it runs in both directions if we expand our view of the world literally force our visual field or just it's very easy actually You can do it no matter where you are right now. If you just try and expand your visual field, not by looking around or moving your header eyes, but by trying to see yourself in the environment that you're in. So you literally dilate your views. You could see the ceiling and the floor and the walls if you're inside. Or if you're outdoors seeing as big an aperture of your visual field or your your visual environment possible. So you're directing your attention to even though you might remain looking straight ahead, you're just directing your attention to as wide a peripheral view horizontally and vertically as possible. Is that what you mean? That's right. Exactly. So essentially, if you keep your head and eyes mostly stationary, you don't have to be, you know, rigid about rock. Steady. But if you look forward and you expand your field of view, so you kind of relax your eyes so that you can see as much of your environment around you as possible to the point where you can see yourself in that environment. What you do is you are turning off the attentional and believe it or not the stress mechanisms that drive your internal state towards stress. This is why when you go to A Vista or you view a horizon, it's very relaxing because you naturally go into panoramic vision. When you are indoors, you're looking at your phone, you're looking at computer, or cameras, something in that sort or you're talking to somebody or an intense conversation, you may not notice it, but your entire visual field shrinks to a much smaller aperture. And that drives an increase in alertness in internal state. And we sometimes call that stress. If it's a negative experience, if it's a positive experience, we might call that love or obsession or it's negative experience. If it's a positive experience, we might call that love or obsession or fascination. But the important thing to realize is that both vision and breathing have a profound and very rapid effect on our internal state of mind and body, and it runs in both directions. Our internal state that could be triggered by a text message or hearing something that somebody says drives changes in our breathing and our vision, but our breathing and our vision can also drive changes in our internal state. And so that article in scientific american was a discussion about how we can leverage the visual system and the respiration, the breathing system. In order to take control over our internal state because it's not just that twenty twenty was stressful. It's that our internal state determines everything. It doesn't just determine if we feel like we're having a hard time falling asleep or we're having a hard time focusing for instance. It also determines how we batch time, how we analyze where we are in the world in terms of our life span. A good example of this would be when we are very stressed, we find sliced time. This is why when people are in a car accident or something, they might report that things were in slow motion. They're actually your frame rate increases. Whereas when you're very relaxed, your frame rate slows down. And when we are relaxed, we get so called perspective. We are able to say, well, this too shall pass or I can place this stressful event in a context. So one thing that's just fundamental to how our nervous system works is that we are constantly placing our experience, both our immediate and past experience as well as our anticipation of the future into some sort of larger context. And our visual system, literally how we are viewing the world at that Cogan, dictates how we create perspective in terms of states of mind. Sounds a little bit abstract, but it's actually it boils right down to optics of the eye and very concrete things like how you move your eyes and how you view the world. This is is super fascinating to me because I've thought a lot about breathing and how on one hand breathing is a function of the autonomous nervous systems. When you're asleep, you don't have to consciously inhale and exhale. But simultaneously, it's this almost API into your autonomic nervous system because while you're awake, you can control and direct and modify your breathing. For that directionality, but I've never thought about it from the from the visual perspective. And just a quick bit of trivia that is out of left field, but nonetheless came to me that people might find interesting, is that the dilation or this hyperdilation of pupils is I don't know how much it is associated with arousal or sexual arousal, but For those who have ever heard the word belladonna is a plant. The reason it's called belladonna beautiful woman in Italian is that it used to be turned into a tincture, and it it is a psychotropic, and it is also very dangerous. I don't recommend people consume it but many, many years ago, hundreds of years ago, women in certain parts of Europe would create a tincture and put it into their eyes to hyper dilate their pupils because it was thought to be very, very attractive, beautiful don't recommend people consume it. But many, many Years ago, hundreds of years ago, women in certain parts of Europe would create a tincture and put it into their eyes to hyper dilate their pupils because it was thought to be very, very attractive. That's beautiful Could you speak to how one can think about using their visual apparatus or stimulating or not stimulating their eyes, their visual system for, say, sleep. If one wants to optimize for sleep, what are some considerations? And it could be that, it could be other inputs, but I'd just be curious to know how this fits into sleep for you personally. Our light viewing behavior has perhaps the strongest effect on our levels of alertness and our capacity to fall asleep and get a good night sleep. And this is because at the fundamental layer of our biology, every cell in our body needs information about time of day. It's no coincidence that we have a collection of neurons over the roof of our mouth, the so called suprachiasmatic nucleus. That's our central circadian clock. It informs every cell in our body about time of day, but it is deep in our brain. It has no access to light. So there are A collection of neurons in the eye, the so called melanopsin ganglion cells, were sometimes called intrinsically sensitive photosensitive gangline cells. These are just neurons in the back of your These are just neurons in the back of your eye remembering, of course, that the eye is actually part of the brain that's outside the skull. And those neurons communicate to the central clock when it's daytime and when it's night. So the simple behavior that I do believe everybody should adopt, including many blind people, which talk about why that is, is to view ideally sunlight for two to ten minutes every morning upon waking. So when you get up in the morning, you really want to get bright light into your eyes because it does two things. First of all, it triggers the timed release of cortisol, a healthy level of cortisol, into your system which acts as a wake up signal and will promote wakefulness and the ability to focus throughout the day. It also starts a timer for the onset of melatonin, this sleepyness hormone or the hormone of darkness as they say. Melatonin is inhibited by light. So by viewing light first thing in the day, you set in motion these two timers, one for wakefulness starts immediately and one for sleepiness that starts later. The key thing here is that people are hearing lot nowadays about avoiding blue light. Blue light is terrible. Well, it turns out that blue light is exactly the wavelength of light that triggers activation of these cells, and that's exactly what you want early in the day. So people generally will say, well, maybe I should just look at my computer and my phone first thing in the day. Well, it turns out that these cells are very hard to activate early in the day and very easy to activate at night. So it's kind of like the biology is encouraging us if you will to take on the right behaviors, which are to get outside even if there's cloud cover, there's a lot more light energy, a lot more photons coming through cloud cover. Then you're going to get off your phone or a you're going to get off your phone or a computer. And early in the day, two to ten minutes outside without sunglasses. Is going to be really beneficial for a huge range of biological functions and brain state. I have made a practice I'm in the middle of nowhere in the country right now of of getting up and not necessarily doing a full workout, but just jumping rope for literally two to five minutes, two to ten minutes outside facing the sun where the sun is working. And there's certainly an effect. I mean, I am moving. So there's an effect on cortisol. And as you noted, it's like cortisol gets this ridiculously bad rap across the board. And it's like, guys, if you don't have cortisol, you're dead. So Okay. If you like having the storing glycogen and breaking it down into glucose and so on you, it's important to have some cortisol. There's a tremendous for me mood elevating effect of this exposure. And I'm just I really have never familiarized myself with the mechanism by which that would be the case. And certainly, if it's placebo, I'm happy to just take placebo. But do you have any explanation for why that Bossier can have such a mood elevating effect. Yeah. It's definitely not placebo. That morning light exposure is going to also trigger the activation of dopamine release dopamine being this essentially feel good neuromodulator. The best way to conceptualize dopamine is that, yes, it's part of reward system, but it's really the molecule of motivation. And positive anticipation. That's really what it's about. And I should mention that the cortisol is going to be released in a pulse once every twenty four hours no matter what. That's coming as we call it an intrinsic rhythm, but you can time it by viewing light and or by getting exercise early in the day. There are actually data to just kind of emphasize what happens when you don't do this. There are really nice data from my colleague David Spiegel's lab. He actually co published this with the great Bob Sapolski a few years ago. David's our associate chair of psychiatry at Stanford. And they showed that If that cortisol pulse shows up later in the day, and especially if it's around eight or nine PM, then it's associated with depression. By shifting that cortisol pulse earlier in the day, you ameliorate some of the symptoms of depression and Because of the dopamine release, you get this overall mood enhancement. There are four things that really time our circadian biology in these mood mechanisms properly and align us for sleep. And they the most powerful timekeeper, as they say, zeitgeist, because Germans discovered this mechanism initially. So the most powerful timekeeper -- Sitekeeper. -- timekeeper. Timekeeper. That's there it is. I know you do better than I would. This is light. When you view light, McKnight is the most powerful stimulus for your biology and central circadian clock. Then it's exercise. So it's your protocol of jumping rope facing the sun. You're layering on time keepers. You're giving more signals to the central clock and the rest of your body about when to be active. And you're also indirectly signaling when you will want to be asleep later. Then it's feeding. I know a lot of people fast through the early part of the day now. That's very fashionable. And I do that as well. But were you too? Eat early in the day, that can also help. And then the other one is social cues. So interacting with people early in the day or with your dog early in the day of a dog and live alone with my dog. So that's how I interact with the world socially. But those things are going to create wake up signals and your body will start to anticipate them and your brain will start to anticipate them such that if you miss it for a day, you're still going to wake up and feel that alertness signal early in the day. So this is not something that you have to do every day, but ideally you do it every day because it's like setting a clock or a watch properly. And I should mention that for people that live in areas with very dense cloud cover, you can use light boxes and things of that sort. But irrespective of that, in the morning and during the day and anytime you want to be alert, you want to flip on as many overhead lights as possible. This is because these cells in the eye that trigger activation and alertness of the rest of the brain and nervous system reside in the lower portion of the eye, they view the upper visual field. Now, the inverse of all this is also important. As you approach the evening or nighttime and you want to go to sleep, that is a time to start avoiding bright lights of any color, not just blue light. And if possible, to place whatever lights are present in your environment, lower in your visual field. So this would be desk lamps. Most people don't have floor lighting, dim the lights, If you wanna wear blue blockers or do something of that sort, that's fine. But I think people have taken the blue blocker thing a little too far by wearing them all day. That's actually going to disrupt your circadian clocks. So in the evening, you really want to avoid bright light of any kind. And again, it's an averaging. If you do this every once in a while, you go to the bathroom no night or you have an emergency and things are really bright for one night. It's not gonna screw you up. However, there was a paper published in the journal Cell A FEW YEARS AGO BY MY GOOD FRIEND AND COLLEAGUE AT THE NATIONAL INSTITutes OF MENTAL HEALTH. HIS NAME IS SAMMER HOTAR. HE'S THE HEAD OF THE Neurobiology UNIT AT THE NATIONAL INSTITUTS OF MENTAL HEALTH. And what Sammers lab showed is that bright light exposure of any wavelength between the hours of about eleven pm and four am cause a serious disruption in the dopamine system such that in subsequent days, you have a disruption and a lowering of mood, difficulty in learning. There's a cascade of things that happen In other words, we get punished for light viewing at the wrong times of the circadian cycle, and we get rewarded for light viewing at the correct times of the circadian cycle. Let's talk about the latter portion of the day. Before I get to that though, just for my understanding, if one say wants to target going to bed more and more accurately feeling sleepy enough to go to bed easily with rapid onset. At, say, ten PM. Is there a preferred time to get that exposure early in the day in the sense that I'm doing my ten minutes of jumping rope facing the sun, is it best to have it a certain distance temporarily from when I want to Go to sleep. Yes, it's about fourteen to sixteen hours prior to when you want to sleep as the ideal time to get that morning light exposure. And if we wanna get a little bit technical about this, we And I'll do my best to make it clear because there's also a way that you can Use this mechanism to shift your circadian clock to avoid jet lag and shift work. I'll just ask you, so what's your typical wake up time? Not getting up in the middle and I'm using the restroom necessarily and then going to actually, but when do you finally get get up and get out bed? What what time does is that typically? I I would say when I'm living my best life and not, not being Marty from back to the future, it's usually seven o'clock let's just say, say when I'm living my best life and not not being Marty from back to the future, it's usually seven o'clock, let's just say. Okay. So if seven o'clock is your average wake up time, then we can be pretty sure that two hours prior to your natural wake up time. Is what's called your temperature minimum. It's when your body temperature was lowest. That temperature minimum. And I should be clear, we don't need to know your actual temperature. No one needs to know their temperature minimum, but can count on the fact that two hours before waking up, your body temperature is close to or at its lowest point. And to be clear, this would be if you are waking without an alarm clock. Right? That would be if you're following natural rhythms. Correct. So if you view light, I should mention that you have to do this light viewing behavior with your eyes. That might seem obvious but some years ago, there was a paper published in the journal Science, which is one of the three Apex Journal Science Nature Cell. And it stated that light presented to the back of the knee of humans could shift their circadian clocks. And that paper was retracted by the same authors that publish the And that paper was retracted by the same authors that published the study, there was a technical flaw. Humans have no extra ocular photoreception. So we need to tell the cells of the body what time of day it is, essentially where we are in time by light viewing behavior with the eyes. Blind people do this a little bit differently. Some blind people actually still retain these so called melanopsin cells. People without eyes at all, maybe from a burn victim or something. They they are going to use social cues and exercise and other things. But most everybody on the planet does this through light viewing behavior. So when I say get light, what I mean is get light in your eyes. Obviously, never so bright that it's gonna damage your eyes. You'll know if a light's too bright because you'll wanna close your eyelids. That's a simple rule of thumb. But the key thing here is that if you view light in particular, bright light. In the hour or two before that temperature minimum. So for you Tim, that would be between, you know, around three AM or four AM. AM. It's going to have the quality of delaying your circadian It's going to have the quality of delaying your circadian clock. What it'll effectively do is make you want to stay awake later, and it will make you want to sleep in later, the following nights. However, if you view light in the hour or so immediately after that so called temperature minimum. So this for you, this would be six AM or seven AM, AM. It's going to shift your clock the other it's going to shift your clock in the other direction. You're going to wanna go to bed a little bit earlier and you're gonna wanna wake up a little bit earlier the next night. Now, If you hear this, you're probably thinking, well, my clock is always more or less in the same place. How come it doesn't jump around? I wake up. I view light. How come I'm not going to bed earlier and earlier every night and waking up earlier and earlier. The reason is, there's a second time of day, which is in the evening as the sun sets. Where your circadian clock is also vulnerable again to these shifts. And typically because most of us are viewing light in the late afternoon, all of us are naturally having our clock shifted so that we want to get up earlier and go to bed earlier the next night and morning. But We're also delaying our clock a little bit in the afternoon. Now we can make this all very simple. The simple thing to do is within thirty minutes, of waking up. Get bright light exposure in your eyes and not from a phone or from screen because it won't be sufficiently bright. Get it from McKnight. And if you can't get it from sunlight, you can use one of these light pads. I don't use one of these expensive wake up clocks or something like that. I bought an LED drawing pad It's like a trace table. It's like the artist cheat mechanism. It actually says on it. I forget the company, but it says nine hundred and thirty lux. You can find these very inexpensively online. And that's gonna work great. I just said it at my desk in the morning. If it's very overcast and I'll work now, it is important to get outside because even though your windows or the windshield of your car is optically clear, it filters out a lot of that blue if it's very overcast and I'll work. Now, it is important to get outside because even though your windows or the windshield of your car is optically clear, it filters out a lot of that blue light that's important for setting your circadian clock. So two to ten minutes of light viewing early in the day, and then you can do yourself a great favor as well by Going outside in the evening or late afternoon as the sun is approaching this what we call low solar angle. Because that will also send another signal to the brain that it's evening. So there's a morning stimulus and an evening stimulus. This only takes few minutes each day and what's Key to understand is that the cells in the of your body, they're gonna have all these rhythms of liver function and metabolic function. Your brain is gonna have its rhythms of alertness and anxiety and sleepiness, providing multiple signals, so for you exercise and light in the morning. And then in the afternoon, a little bit of light, is going to tell your system in a redundant way, but in a powerful way, these are the times to be awake, these are the times to be asleep. And then if you like, we can talk evening behavior, but that temperature minimum is worth knowing. Because if ever you are traveling for instance to Europe, what you can do is in the two or three days before, You can just set your alarm wake up around your temperature minimum of maybe an hour before. Turn on some bright lights in your home So you get bright light exposure and you will start to shift your clock forward. That nine hour jump can be accomplished in about two days if you do this correctly. And the reverse is also true. You could shift your clock earlier if you like. And when you land in Europe, if we wanna get down into the weeds, when you land in Europe, you have to be cognizant of what your clock is back home. Remember your temperature minimum. It's much more important than where you are in your new environment. That temperature minimum is an anchor point. Remember, light viewed in the hour or two before that temperature minimum will make you want to go to sleep later and wake up later. Light viewed after that temperature minimum will make you want to go to sleep earlier and wake up earlier. Let's talk about something that is a perennial topic and that is sleep aids Specifically, I'd love to get your opinion on various supplements or prescription medications for that matter that people might use. There's a huge list of things that people could use. On the prescription side, certainly you've got the ambiance and the trazodones and so on. Then on the supplemental side, you've got melatonin, very very popular. You have California poppy. I mean, there's an infinitely long list of various supplements. I would love to hear your thoughts on at least two of these one is melatonin because of its I would love to hear your thoughts on at least two of these. One is melatonin because of its popularity. And then the second is actually phosphatidyl sharing. So p s for short and using it to blunt cortisol release after going to bed. And I'll just be curious to know if you have any opinions on those or any others that you would advise against or advocate for or use personally. Sure. So I'll say why I'm not a fan of melatonin. When I was a graduate student, I worked on the Melatonin system and the circadian system. And one of the most powerful effects of Melatonin is to suppress puberty. The melatonin system is closely linked up with gaba inhibitory neurons in the hypothalamus. It effectively keeps puberty from It effectively keeps puberty from happening. So the melatonin rhythms of young children, preoperative children, are not asphasic. McKnight? They're pretty constant. And that's one of the reasons they don't go into puberty. There are many other reasons they don't go into puberty until certain triggers are set. But Melatonin has strong effects on the sext steroid hormones that pathways relate to estrogen and testosterone. I think it was the one experiment that I did where we took we were working on these little they're called Huberman hamsters, these little hamsters who in long days because they are seasonally breeding animals. In long days, these Huberman hamsters have testicles, well, that at least for hamsters are a pretty impressive size. If however, You inject those animals with melatonin or you put them into short days, so you increase the amount of darkness and you decrease the amount of light remembering, of course, that light inhibits melatonin. They're testicles shrink to the size of a grain of rice. So I don't know if this was my male ego or something, but I saw that experiment And I thought, wow, this is powerful stuff, this melatonin stuff. And it turns out in females of the same species, they leave estrus, they stop cycling. They don't have menstrual cycles. They have Ester cycles. And there are powerful effects of melatonin on the reproductive axis. Now humans are not seasonal breeders and We have a more robust, sex steroid hormone access than that. But especially for children, but also for adults, it just seems to me that melatonin has a number of other effects that are worth considering enough effects that I tend to avoid it. Now, I should also say that most of the concentrations of melatonin that are in supplements are ten to one thousand times what the endogenous internal levels would naturally be. So people taking melatonin are seeing dramatic effects, but you're taking super physiological levels of melatonin. We all kind of balk when we hear about people taking, you know, a thousand milligrams of testosterone, sippionate a week, which unfortunately certain people do. But this is the equivalent of super dosing, sleep hormones. And these are hormones that have other issues and other roles I should say in the body. So that's why I veer away from melatonin. Also, there are three things that I personally have found to be much more beneficial. That seem to have very good safety margins. Of course, everyone needs to check with their physician. But those three things are magnesium three and 8THRE0NATE, or by glycemic, magnesium by glycemic. Magnesium-three nate and magnesium bicinate are able to be transported across the blood brain barrier more readily than other forms of magnesium. I know you know a lot about this topic, Tim. So correct me anywhere I might misspeak. But like for instance, magnesium citrate is a great laxative. Goes by another name too, you can imagine what it might be. That will remind you that it's a it's a great laxative. What it's not great at inducing sleep magnesium, three and eight or magnesium bicarbonate, so two hundred to four hundred milligrams. About thirty minutes before sleep is a powerful sleep aid. People with heart issues might not want to take it or might want to check with their doctor, but I take a cocktail of magnesium three and eight, and then two other People with heart issues might not wanna take it or might wanna check with their doctor, but I take a cocktail of magnesium three and eight And then two other things. One is very commonly known, which is thehenine, THEANINE2 hundred to four hundred milligrams of thehenine. Can create a kind of a hypnotic state, help you fall asleep. Basically falling asleep requires turning off your falling asleep requires turning off your thoughts. And the only people that should really avoid Theanine I think, are people who suffer from sleepwalking or night terrors, it can create very vivid dreams. And then the third thing is ApoGenen, APIGENIN, which is a derivative of chamomile, but it acts as a chloride channel agonist. So it essentially helps shut down the fore brain by hyperpolarizing neurons and all this kind of stuff for the aficionados. If they want to know. So that cocktail of fifty milligrams of ApoGenon, three hundred milligrams to four hundred milligrams of magnesium, three and eight or bicarbonate, and two hundred to four hundred milligrams of theanine, for me has been the best way to consistently fall asleep quickly and stay asleep most if not the entire night, which for me is about seven, eight hours. And of course, I'm not a physician. I'm a scientist. Everyone needs to figure out what's right for them. But many many people who I've recommended this to have told me that in combination with the morning light viewing, that their sleep has been completely transformed. They thought they were so called insomniacs, but they actually were just having a hard time turning off their thoughts and probably their court is always drifting too late in day. So to that, court is all point. This is fascinating. And I just find it endlessly interesting that different forms of magnesium can be so target specific with respect to different tissues in the and I just fight it endlessly interesting that different forms of magnesium can be so target specific with respect to different tissues in the body. So so fascinating. With respect to cortisol and needless to say, I I have used fosteal searing before sleep to help blunt cortisol release, but I do cycle I use it as needed really if there's a lot of rumination or I've had a particularly stress full day. But do you have any thoughts on whether or not you would ever do that personally or if you'd be too concerned about side effects or long term side effects. I suppose that could be a larger issue if you're just never cycling off. But do you have any thoughts on using different compounds to blunt cortisol release if you're over ruminating and want to sort of minimize that, in this case, stress response while you're trying to sleep I have not tried PS. I use Ashwagonda from time to time if I'm in a particularly long bout of stress One of the things that think is relevant here is that we hear about stress, but as terrible. But of course, short term stress buffers immune system. It actually activates the spleen to release killer cells and things of that sort, we Are more robust in fighting off infection in the short term from pulses and are more robust in fighting off infection in the short term from pulses and cortisol. But I would say we can define long term stress as if you are having sleep disruption or you're feeling like you're in that wired and tired mode. We don't really have a technical name for this. For more than two or three days, you're starting to enter that realm of long term stress, and that's where buffering cortisol can really help, and that's where I start to take some martial gondolas late in the day, there is good evidence that can buffer cortisol. I do cycle it. So I'm not going to take it every night or every so I'm not gonna take it every night or every day. I would probably stop after a week Cogan. then just go back to my normal regimen, which doesn't include Ashugana, but I always have some on hand. I have to say that I certainly use and enjoy the benefits of supplements many of them in fact, but the practice that for me has really helped reduce stress and allowed me to fall asleep more easily and control my state of mind late in the evening is this practice that some people call Cogan Which literally means yoga sleep. And that practice of taking twenty or thirty minutes a day and it doesn't have to be done every day. And line down and doing a sort of body scan, it involves some long exhale breathing, which is very relaxing to the nervous system. And really allowing the mind to enter one of these pseudo sleep states. We know from work in my laboratory and work that I'm doing with David's Biegle's laboratory as well as work from other labs, that that state of shallow nap or shallow sleep done in waking allows the brain to and the person to get better at turning off their thoughts and falling asleep in the evening. So I I use both behavioral tools and pharmacology, which of course is really what supplementation is. I don't have any problem with buffering cortisol little bit in the short term, so doing that for a week or two. But I wouldn't suggest that people suppress their cortisol long term unless there's a real clinical need to do that. Long term being longer than two weeks. Just a quick thanks to one of our sponsors and we'll be right back to the show. This episode is brought to you by athletic greens. I get asked all the time, what I would I get asked all the time. What I would take if I could only take one supplement. The answer is invariably athletic greens. I view it as all in one nutritional insurance. I recommended I recommended it. In fact, in the four hour body, this is more than 10 years ago and I did not get paid to do so with approximately 75 vitamins minerals and whole foods sourced in fact, in the four hour body, this is more than ten years ago, and I did not get paid to do so. 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So adding a vitamin D supplement to your daily routine is a great option for additional immune support support, your immunity, gut health and energy by visiting athletic So adding a vitamin D supplement to your daily routine is a great option for additional immune support. Support your immunity, gut health, and energy by visiting athleticgreens dot com slash Tim. You'll receive up to a year's supply of vitamin d and five free travel packs with your subscription. Again, that's athletic greens dot com slash temp. You mentioned long exhales in the context of the yoga need your practice. Is it fair to refer to that yoga need your also non sleep deep rest or NSDR are those separate phenomena? Yeah. So, is one of several what we call NSDR non sleep deep rest protocols. Admittedly, I coined the term NSDR because scientists like acronyms, almost as much as the military likes acronyms. And I did it deliberately not to rob the beautiful history and community that is Cogan and the yogic communities of anything. But rather because many people are averse to doing anything that has a name like Yogenidra. And yet it's such a powerful tool. It's a zero cost tool that has enormous effects on not just accessing sleep and calm, but enhancing rates of neuroplasticity, something that we could talk more about. Also David Spiegel Again, our associate chair of psychiatry at Stanford, a close collaborator and friend of mine, is a world expert in clinical hypnosis. We are part of a just in in full disclosure. We both sit on the advisory board of a company called reverie, R E V E R we both sit on the advisory board of a company called Revere, REVERI, dot com, reverie is a zero cost app beyond Android and Apple that has short hypnosis protocols anywhere from ten minutes to fifteen minutes. Hypnosis and Cogan both fall under the umbrella of NSDR, non sleep depressed. And these are protocols that People can use to deliberately access states of deep rest for sake of, again, falling asleep more easily, reducing stress, but also for enhancing rates of learning of neuroplasticity. And because these are zero cost tools, and because they're grounded in excellent peer reviewed research, I feel comfortable mentioning them. And what you find is that if people who are not familiar with meditation or mindfulness or maybe they're not from West LA or the Bay Area. If they hear Cogan, they think magic carpets and they think and they hear hypnosis and they think that somebody is going to control their brain. NSDR is my attempt to create a more friendly language. Which is because all of these things are really just the same thing. They really involve two things. One, self directing a state of calm. That's something that we never learn how to do unless we have a need to do it. We suffer some trauma. We have chronic stress. We start taking a mindfulness class. We self inducing a state of calm through respiration and vision. Is the hallmark of Cogan and hypnosis, and frankly, of all meditative practices. Our thoughts follow our vision and breathing. And I can explain why that is in a and I can explain why that is in a moment. In addition, these NSDR type practices involve not just self directing calm, but they also involve directing our focus to something. We generally have a hard time falling asleep because we think we have to turn off our thoughts completely like a switch. But the transition to sleep involves allowing our thoughts to become fragmented. And then we become relaxed, and then the brain enters the state where space and time are very fluid and not under our conscious control. And those are things that we can teach ourselves. So need your scripts are found all over YouTube. There's some great apps out there. The zero cost ones that I use are any of the stuff by comedy, KAMINI Desai, DESAII like her voice very much. Some people like my sister loves Liam Gillen's voice, another zero cost ninja tool, Liam Gillen, a double LGILLEN. You have to find a voice that you like. The reverie app is David's voice. He has a very hypnotic voice. And there are scripts in there for smoking cessation, stress and anxiety, sleep, etcetera. These I really wanna emphasize in addition to being zero costs are very powerful tools, if done regularly. There are two papers that were published in the last two years from cell reports and cell press journal, excellent journal showing that a twenty minute non sleep deep breast protocol. After about of intense focus or intense attempt to learn anything skill learning or cognitive learning accelerates plasticity by about fifty percent So you are learning faster, much faster, and retention of that information lasts much longer. And that's because these are sleep like states, and we know that neuroplasticity, the brain's ability to change in response to experience, is triggered by high focus. By deliberate periods of very high focus, but the actual rewiring of neurons, the formation of new synapses, and the reordering of the circuitry that leads to that skill or that cognitive ability becoming reflective. That happens in states of deep rest. And non sleep depressed NSDR, whether it's hypnosis or Cogan or a shallow nap of about twenty, thirty minutes, those things will all accelerate learning. Let's hop around just a little bit. Yogi Nidra first on the NSDR study that you mentioned and increased in plasticity, which I'm assuming was measured by retention recall, etcetera. But perhaps it wasn't. If you could send Afterwards, I'll link to that study. I'll put it in the show notes for listeners who who might interested. We've touched on breathing in a few different capacities I have a term in front of me that seems kind of self explanatory, but I don't know what form it takes. Physiological size contrasted with other breathing methods for stress reduction. Could you define what that is? Yeah. A few years ago, when my laboratory got interested in studying stress in humans, we asked ourselves what are the patterns of breathing that allow for the most rapid reduction in stress levels. And more importantly, what are the patterns of breathing that can be done in real time? So that people can adjust their stress while they're still engaging in life. Right? Breathwork classes running off to Epsilon for a weekend is a magical experience, but life demands pressing on you. That's typically when you feel stressed. So it is still true that vacation, long meditation retreats, and massages, or nice drink. If you're of drinking age, still work, but they're slow and they take you offline. The physiological side is a pattern of breathing that was actually discovered by physiologists in the thirties. And that was essentially rediscovered by Professor Jack Feldman at UCLA, a world expert in the Neurobiology of respiration. And by my colleague Mark Krasno at Stanford, who studies lung function. The physiological side is a pattern of breathing that we all engage in, In deep sleep, when levels of carbon dioxide in our bloodstream get too high, we or our dogs you can see your dog do this will do a double inhale followed by an extended exhale. Children or adults for that matter that are sobbing and lose their breath, so to speak, we'll also do a double inhale exhale. That's the spontaneous execution of what we call the physiological sigh. The reason it works so well to relax us is because it offloads a lot of carbon dioxide all at once. And the way it works is the following. Our lungs are not just two big bags of air. We have all these little millions of sacks of air that if we were to lay them out flat, they would be as as big as about a tennis court or so. The volume of air, therefore, and the volume of carbon dioxide that we can offload is tremendously high, except that we get stressed as carbon dioxide builds up on our bloodstream and is kind of a double whammy. These little sacs deflate. Now when we do a double inhale, so I'll do this now twice through my nose or you could do this or you could do it through your mouth, but it works best through nose. It's inhale. And then you sneak a little bit more air in at the very end. When you do that, you reinflate those little sacs. And when you exhale, then you discard all the carbon oxide at once. So the simple way to describe this protocol is that unless you are underwater, you do a double inhale followed by an extended exhale and you offload the maximum amount of carbon dioxide and we found in our laboratory and other laboratories have found that Just one, two or three of those physiological size brings your level of stress down very, very fast. And it's a tool that, you know, you can use any time. I do hope that people will kind of watch other people or dogs as they start to relax or go down to sleep, you'll see this pattern of breathing. But Again, it can be consciously driven. The other thing about breathing and the reason why exhales are so vital is the following. I know there's a lot of interest nowadays in heart rate variability. Well, most people don't realize this, but your breathing is actually driving heart rate variability. When you inhale, this dome shaped muscle beneath your lungs, your diaphragm actually moves down because the lungs expand, it moves down. When you do that, you create more space in the thoracic cavity and you actually the heart gets a little bigger. It actually expands. As a consequence, blood flows more slowly through that larger volume, and the brain quickly sends a signal down to the heart to speed the heart up. The short simple version of this is inhales, speed the heart up. When you exhale, the opposite is true. That dome shaped muscle, the diaphragm moves up. The space in your thoracic cavity gets a little bit smaller. The heart gets a little bit smaller. Blood, moves more quickly through that small volume and the brain sends a signal to the heart to slow the heart down. Physicians know this as respiratory sinus arrhythmia But this is the basis of what we call HRV, heart rate variability. And the simple way to remember this is anytime you emphasize exhales, in other words, making them longer than your inhales, you are slowing the heart rate down. You're calming your you're calming your system. Anytime you emphasize inhales, you make them more vigorous or longer than your exhales, you're speeding up your heart. I'd like to come back to hypnosis for a second. I've never been hypnotized nor, but maybe I have self hypnotized and just not realized. That's what I was doing. What characterizes hypnosis or how would we define that? And do the states induced by hypnosis have any shared characteristics with some of the states induced by any psychedelics. So hypnosis is a state of calm and high hypnosis is a state of calm and high focus. So context is restricted. It's like looking at something through a telephoto lens. You're eliminating the surround. So it's a state of high focus, which normally as we talked about earlier with the aperture of the visual system would be associated with a high degree of excitement or stress. But hypnosis is a unique state because you have a high degree of focus, but you're very relaxed. And just to remind people that neuroplasticity is triggered by states of high focus, followed by periods of relaxation later in deep sleep or in non sleep deep rest. In hypnosis, it brings both those states together at the same time. And this is one of the reasons it's effective in accelerating neuroplasticity. I could probably do it right now to see if how hypnotizable you are. There's actually a test, a clinical test called the Spiegel I roll test. Spiegel's father was a hypnotist and a psychiatrist. So these I want to be clear, these are not stage hypnotist. These are board certified MDs and PhDs who there's a lot of scientific research to support what we're about to talk about. So Typically, when we get sleepy, when we're relaxed, our eyelids close and our eyes go down and the chin goes down. The induction to hypnosis involves doing the opposite, looking up, which actually believe it or not, creates a state of alertness, and then having you close your eyes. So it creates kind of conflict in the cranial nerves that innervate the eye and eyelid muscles. Again, the eyes in your state of mind are so intricately wired back there in brainstem. So if you could look up toward the ceiling, Tim, with your eyes And then just while still maintaining upward gaze, if you could just slowly close your eyelids. Oh, boy, you're really hypnotizable. So what did you did you see? That was deeply uncomfortable. Yeah. I know. It's it's a little bit odd. So so for those of you listening or watching, you you sort of look up towards what, you know, sometimes in yoga communities that you or been limitation use they call the third eye center. You know, we don't actually have a third eye. But if we did, it would probably be someone decided it would be between our two eyes and our forehead. So by looking up, you're inducing alertness. And then you're creating this conflict where we're I asked you to close your eyelids, which is what you do when you're in a state of sleepiness. And what Spiegel, both Spiegel Senior and Spiegel Jr. Have figured out, is that it's a very good predictor of how hypnotized will people r, you can look up the Spiegel I roll test. And what I was looking for is, let's say, if somebody is not very hypnotizable, what'll happen is as they close their eyes, they'll have a hard time closing them slowly, they'll just kind of snapshot and their eyes will roll forward. In other words, I'll see their pupils again. What happened when I saw you do this is that your eyelids were closing very slowly, and I saw the whites of your eyes. Your eyes were starting to roll back into your head. So you would have a score of probably about a four which is very hypnotizable. I'm about a four. Some people you'll just notice you say look up and then slowly close your eyes and their eyes will just kinda snap shut and their eyes will roll forward right before it snaps shut. So you can do this experiment of sorts on people that you know and it predicts pretty well how quickly or easily you will go into hypnosis. I should mention that no one will go into hypnosis if they don't want 2017. If you're interested in exploring hypnosis with the reverie app or with the clinical hypnosis and your eyes roll back the way that yours did him, then you're home For a year, you're going to be You're you're gonna be long Amazing. I could maybe I'll start speaking in tongues too. It does have a good good associated look with it. How would you explain the utility of hypnosis And then I do want to hear if there are any sort of correlates to some of the known effects of psychedelics. And that's a wide spectrum of class. So we could choose -- Sure. -- a given compound. But what are the what are the clinical applications? Because in my hypnosis naive mind, I think smoking cessation, isn't it good for quitting smoking, isn't it good for really just these anecdotal reports that I've read at one point or another? But what's the sort of clinical are some of the clinical applications or practical applications of hypnosis? Yeah. So for smoking cessation, if people do the practice, about a sixty percent to eighty percent success rate depending on the study you look at. These were all blinded controlled studies in terms of anxiety relief, Those are tremendously strong effects, as many as ninety percent of people are going to feel significant improvement in anxiety for pain management, for chronic pain, there's a high degree of success. So, you know, people will vary depending on how hypnotizable they are and how regular they are about the plasticity anywhere from fifty to seventy five percent of people will experience a significant reduction in chronic pain. And if they are using pain meds, they tend to be able to take lower doses of pain medications in order to manage that pain. So it's it's quite powerful. Now for trauma, and things of that sort. It needs to be done with a clinical, I would hope, board certified MD clinical hypnotist. And there the success rates are are quite high as well. And if you want more research about this inside the reverie app, there's a long list of resources. You could also I can send over a a good review article that David's written. And these are again published in very fine quality peer reviewed journals of the New England Journal, JAMA, sort and things like that. Right? In terms of similarity to psychedelics, they are quite distinct actually. So hypnosis being a state of high degree of focus and relaxation is a bit similar to some of the so-called So hypnosis being a state of high degree of focus and relaxation is a bit similar to some of the so called psychedelic. So MDMA assisted psychotherapy, which appears thanks to the support and work of people like you and the maps group and the group at Hopkins, in particular, Matthew Johnson. And I realized there are other people in that mix, but it's it. I have to just say as a, as a point, it's, it's really exciting to see what's happening and the enthusiasm about safe building, safe protocols that people can access after so many years of people having to do this kind of Renegade or in unregulated environments, MTMA creates an, a very atypical I have to just say as a as a point, it's it's really exciting to see what's happening. And the enthusiasm about safe building safe protocols that people can access after so many years of people having to do this on a renegade or in unregulated environments. MDMA creates in a very atypical state. It's a state of high dopamine release. Typically dopamine is associated with a focus on things external to us. Dopamine being a a moly associated with motivation and reward makes us want to do more of things that brought the dopamine, whether or not that's food, sex, online viewing of any kind, etcetera. That's not always -- It's not always bad. -- that online viewing. Online viewing, whatever that is. The best way to describe the effects of dopamine are that there's a book actually quite good book called the molecule of more and that's a great way to describe it. I wish I had written that book. I read the book and thought, I wish I'd written this book. It's because I I love the neuromodulator systems and it is the molecule of more and actually Anyone that thinks that dopamine is about pleasure, not motivation, or seeking more? Consider this. This is an anecdote I borrowed from my colleague, Anna Lemke, who's in the Department of Psyche tree at Stanford. The next time you eat a piece of chocolate or you engage in a behavior that feels particularly delicious. Notice the sensation and the thoughts in your mind. It's rarely about complete presence and desire for staying present, it's usually a desire for more. It's this, I want more of this, please, as opposed to really basking in the experience. And I should mention that Anna has a wonderful book coming out in August called Dopamine Nation. She was in the social dilemma. She's an addiction therapist. And psychiatrists, and talks a lot about the dopamine system. So dopamine makes us want more of whatever feels really good. And that tends to place us in an external focus. Serotonin, another feel good molecule, is a exact opposite. It tends to make us feel good with what we already have. It tends to be the incredible feelings of of warmth that, you know, holding a child or a loved one or time with your dog. I have this bulldog Costello there's times when I just sit with him and I feel immense pleasure just being there. I don't think I want four bulldogs. That I definitely don't want four full dogs. The snoring is loud enough already. But it's about experiencing the hearing now in a full and complete way. MDMA is unique because it creates huge increases in dopamine and serotonin at the same time. And we don't ordinarily see that in natural experience. And it has this unique property of making people feel very excited and positive about their relationship to their internal state. And so it has a kind of looping back of a mechanism that normally would place us in the viewing of the exterior. What's out there? What can I get more of? Who can I interact with more of? What drug can I take more of that's going to make me feel this way? So MDMA is very unique. And I mentioned it because it has certain correlates with hypnosis in that it's a very focused state. In fact, so much so that let's just say I could imagine that if you're hearing music and you focus on that music, you can really kind of start to merge with the music, whereas if you focus on your internal state, you can merge with your internal state. And that's why I do think it's important that some of that if people are doing it in a clinical setting be guided because otherwise the experience can be sort of lost on whatever is external. Other psychedelics of the sort like psilocybin and LSD, they have a very sleep like state. They tend to be more serotonergic in nature. And they are very similar to sleep in the sense that space and time very fluid. Whatever top down governing mechanisms exist in the brain, so called executive function. Some of that seems to be dysregulated enough so that inside of those psychedelic states and in certainly inside of dreams, anything can really happen and you can essentially see and appreciate novel associations that normally wouldn't occur in waking states. We should remember that the two extremes of human experience are stress and or excitement, so highly contracted visual window highly contracted time domain. Everything sliced very finely. What's happening next? What's gonna happen next? think you're in the line at the airport and the first in front of you is moving slowly and you got a plane to catch. Everything constricted McKnight there, both in space and time. And then sleep, where in sleep, space and time are extremely fluid. Anything can happen and you are essentially out of control mentally. It's just whatever is gonna happen is gonna happen. Cycled Alex, are very much like that except that in LSD and psilocybin assisted states, you're alert. So I would say that psilocybin and LSD like states are similar to hypnosis. This in that way. But hypnosis has a little bit more of rigidity to it. It's set toward a particular focus. Like, let's work on your control over stress or smoking or pain. And so I would say the three of them occupy neighboring spaces, but none of them overlap completely. And I'd be so curious to see some type of multimodal study. And perhaps they've been done, but just looking at pharmacological interventions combined with hypnosis. Right? So if we made hypnosis, the the default sort of control state, and then you had an arm that was comparing hypnosis plus fill in the blank, not necessarily psychedelic certainly. I mean, you could it could be an intact degenerative and an empathogen like MDMA. It could be tryptamine like psilocybin. Or it could be like a phenethylamine, like masculine, which has very different effects. Certainly, think Michael Pollan does a good job of of describing this in his new book, your mind on plants is an entire section discussing the the mezzolan experience, which is really in a sense, an amplification of the real in high resolution, certainly dose dependent versus transportation. Allow the tryptomines like LSD or or psilocybin. That'll be very very interesting to see. It would. I and I have to say, you know, as usual, you're you're five years or more ahead of everybody else, 2017, and I don't say that for sake of flattery. I mean, you have a you have a way of spotting the horizon. And I think we are so caught up as a culture now in asking, what should we do? What should we take? What device should I use? I would say, you've got behavioral tools. We all have to eat sooner or later. Nutrition, supplementation, prescription drugs, off label and on label, and then you got brain machine interface devices for reading and writing to the nervous system and body measuring things and changing things. And we always think of those as separate bins. But as you're pointing out, I think the most interesting bin is to consider Well, maybe at some point a learning bout is going to be three hundred milligrams of alpha GPC and a particular breathing protocol that will have a synergistic effect. I think that's where the real immediate future of beneficial brain change lies. And I think even the folks at NERLYNQ, a guy that came up through my lab, he's a neurosurgeon, Matt McDougall, is that neural link now. And they have other excellent neuroscientists there. And You can be sure that they're thinking clinical issues first, and they're thinking obviously brain machine interface and chips and robotics and things of that sort. But you can bet just given who makes up that company of roster that they're probably also thinking about ways to accelerate plasticity using a combination of brain machine interface and pharmacology. And if they're not thinking about that, they definitely should. So I think for the typical person who's not getting plant a chip neath their skull, I think you're hitting the nail on the head, which is that we need to think about what works independently and combining those for sake of synergy. That's what's gonna get us where we need to go much faster. I also think just to build on what you said and thanks for the kind words that when you look at these possible synergistic combinations, you could also end up and then this is not a certainty, but it's a possibility having a much more appealing risk benefit calculus in the sense that if you can lower the required dose of a pharmacological intervention, if you can lower the exposure necessary with some type of neurofeedback or neurostim like a TMS or a tDCS or any of these other tools, if you're able to lower the required doses of several things, when they're used in combination and get a similar or better outcome, it just has such incredible ramifications for the, for the clinical use of these I also think just to build on what you said and thanks for the kind words that when you look at these possible synergistic combinations, you could also end up, and then this is not a certainty, but it's possibility having a much more appealing risk benefit calculus in the sense that if you can lower the required dose of a pharmacological intervention if you can lower the exposure necessary with some type of neurofeedback or Neurostim like a TMS or a TDCS or any of these other tools. If you're able to lower the required doses of several things when they're used in combination and get a similar or better outcome. It just has such incredible ramifications for the clinical use of these things. Let's take a step back here. So now we've covered a bunch of the research. We've covered a bunch of the sort of tactical practical implementations of some of the research findings. Now I wanna paint a picture for people who don't who don't know you at all. We've already covered Casella. We have not discussed the fact that you have looks like full sleeve tattoos on both arms. I think you're the guy. I think you outed think you outed me. Yeah, there's a, you're the first that's the Yeah. There's a you're the first. That's just the first. Yep. It's true. Alright. Birthmark they're all birthmarks. Of course. They're all birthmarks. Kids don't start because they're like potato chips. I get this one. And we may get to aquascaping. That's a whole separate conversation, so we may get to that. But I wanna I wanna rewind the clock for a second because I read your bio. Obviously, very impressive. Bio you've received numerous bio. You've received numerous awards You've produced a lot of incredible work with your colleagues and your your lab. Let's go back to What happened to you in July of nineteen ninety four? So in July of nineteen ninety four, I was living in a little town called Alevista, which is near Santa Barbara. It's the home of UC Santa Barbara, University of California Santa Barbara. Just as a little bit of background, I was not a good high school student. I had a very disrupted high school experience despite growing up in a in a good area. Just a lot of tension and and stuff at home. So I barely finished high school, but I followed a high school girlfriend off to college. Somehow I got in at the time I wanted to be a firefighter, took fire science courses at Mission College in the South Bay, and I thought I'd be a firefighter and I put that in my entrance exam and somehow they let me in. But by the end of my freshman year of college, I had terrible marks. I had been thrown out of the dormitory living for getting in fights, something I'm certainly not proud of. And I was basically doing nothing. That summer, I was living in. I was I was squatting. I was living in an empty house because a lot of the houses were empty. I figured, why pay rent, you know, and I'm living in an empty house with with my pet fairit. And to sort of set the context I was I think I was still grappling with a lot of anger and resentment and confusion based on having a rather confusing teenage years and and a lot of disruption. Fortunately, I'd formed a lot of friendships and formed community in the skateboarding and punk rock culture. I was fortunate enough to get to know a lot of guys that have gone on to do great, like my friend Carl Watson is an Adidas skateboarding. I I spent some time and got to know although we weren't close friends with the great Danny Way, probably the great one of the greatest skateboarders of all time, jumped the great world of China. But I wasn't a very good skateboarder. I was not a musician. I knew how to do essentially nothing well. And July fourth nineteen ninety four, I went to a barbecue with some friends and some guys were robbing the house that we were having this party at. We came back from the store and we saw these guys essentially taking a bunch of possessions out of the house. And the thing erupted into this big fight, this huge melee. I definitely went in, excited to fight. You know, been involved in fights before and I had an adrenaline seeking thing. I felt like it was justified. I'm certainly not encouraging anybody else to do this, but essentially what happened was my friends took off, my so called friends took off, and I ended up in a fight with, like, four or five guys, knives came out bottles. It's the sort of thing where quickly you realize that Things could go badly wrong. Fortunately, I stayed on two feet and nobody got badly hurt or killed. The police showed up and actually because of the fact that they were robbing us, they actually congratulated me. I'll never forget, this is actually what made me feel worst of all, because one one of the police officers said, you know, like, nice work or something like that. And I and I just realized that I was in serious trouble, you know. I'm nineteen, I barely finished high school. I barely scraped through my first year of college. I'm living in a squat with my ferret. My girlfriend had left me I didn't do anything well. I didn't know how to do anything well. And so that day and I still have this letter. I actually sat down and I wrote a letter to myself and to my parents saying that I was gonna turn things around. And I don't know why I wrote to them because at the time I was kind avoid in contact with them entirely. I've since formed a really good relationship with both my parents, but I decided that day that I would use the one power that I seem to have, which is to remember facts and information. And what I did was I I left Santa Barbara, I took leave of absence, went back, went to a local community college in the Bay Area. I did two quarters there, and I just started studying like a maniac. First, psychology, then biology. I eventually fell in love with neuroscience and related themes of endocrinology and and the rest is sort of history in terms of eventually going to graduate school and getting a PhD and becoming a professor, tenure, and all that stuff. But It was one of those moments where I realized I am no longer going to be a young screw up. I'm gonna be a twenty year old screw up. And with time, people are gonna be less and less forgiving. And whatever had happened prior, no one's gonna care. It doesn't even really matter. And if I do want people to care and it's not like I have a need to talk about the challenges early on, but I need to get my act together. I need to do something. I need to get good at something. And so became a a kind of a maniac. Actually, when I read your your book, the four hour workweek, and the four hour body, which I read and loved and own, I should say, again, not for sake of flattery because they but they really helped me. There are a lot of useful tools in there. There were certain things that resonated. I figured out that if I drank a lot of coffee and took certain supplements, I could focus for many hours. And then if I worked out, I built another capacity. And if I ran, I built another capacity for endurance. And I started to explore the crossovers between weight lifting is one thing. It's not about building muscles or necessarily maybe it's about that. It's about really moving against a physical force in real time and really learning how to do that. Endurance work is about learning how to push through a different kind of barrier and learning the carryover and crossover points. So I was the guy that would sit down at my desk. I moved I decided to live alone in a studio apartment and I would set a timer for several hours and I wouldn't allow myself to get up. I was allowed to listen to rancid, best band ever for me on repeat and Bob Dylan. That's all I I wouldn't even allow myself to change music. And then I would just sit there and I would read my textbooks, underline my textbooks, write my textbooks, and I just decided, I'm gonna get straight A Mark, so I'm gonna go to graduate school, I'm gonna get a PhD should mention there were people that came along at various times and helped me roll models, mentors, people that spotted that, but it started with a switch that flipped on July fourth nineteen ninety four and getting in a bad fight. And here I am deciding to choose different path. So I I want to underscore or explore a few things, and I really appreciate you sharing this because I think it's very easy for people listening to folks with a bio like yours to sort of assume a certain trajectory assume that it has always come easy and that you've always, since you were two years old, knowing exactly what direction you're heading, which is not the case. One clarification with UC Santa Barbara, this might be an important point. It might not. You did not drop out. You took a leave of You took a leave of absence. Is that right? Is that material to the story? Because I know in a lot of cases, There are folks who were kind of painted as dropouts, but in fact, they kept their options open by taking the leaf of absence instead. So I just want to clarify. Yes, a leave of absence is a mechanism that most universities have. I think it was a design for things like family situations if somebody gets pregnant or they have family member who's sick, that allows you to leave and come back. And it's distinctly different from dropping out. Although I was pretty close to dropping out of being forced to drop out for reasons related to poor grades and poor I was pretty close to dropping out of being forced to drop out for reasons related to poor grades and poor behavior. Fortunately, that didn't happen. I think it's a really important point because we hear that Bill Gates dropped out of college. Steve Jobs dropped out of college. Mark Zuckerberg dropped out of college. I think Maybe it was Ryan Holiday who I don't know who said something like the the people who are doing poorly in college, they're the ones that should stay in college because It's that one environment where everything's scripted out for you, what you need to do in order to hit the next metric of success. And a leave of absence is very different. None of those people dropped out of college. They took leave of absences that gave them an insurance. Policy that they could go back if they wanted to. And it's very hard to make it back into a system of any kind but it certainly is much harder if you completely divorce yourself from that system. I am a believer in formal, rigorous coursework I am a university professor. I know that college isn't perfect for everybody. McKnight be the wrong decision for certain people. But if you're still uncertain about what you wanna do. I think if it can be arranged financially and it's in the scope of things that somebody might wanna do, I think learning how to sit down in a chair and force yourself to learn, and then compete with others in terms of how well you learn that information, I think is a great way to evaluate oneself early in life and it sets the stage right. I agree with them. If you're open to it and certainly you can say no or we can talk about it and then you can elect to have it edited out of the conversation. But you mentioned tension and stuff at home. Disruption. Are you open to sharing a bit more detail about what you mean when you say those things? Sure. So I had a pretty magical So I had a pretty magical childhood. Really, my dad's a scientist. My mom wrote children's books and was a teacher. We ate dinner as a family. Everybody together in the early part of life. I I acknowledge that I had great privilege in having that experience and growing up where I did, good schools, good public schools. I completely acknowledge the benefits of that especially early in life. Around thirteen, when I was thirteen, my parents split up. And either because of the time in which it happened or because they weren't equipped with the right tools, there was a complete fraction of that picture. My dad was very much out of the picture at that time. My mom hit, I think, series of challenges adjusting. I think it was a may what could only be described as a a major depression. I think her view of family was one in which everyone stuck together no matter what. She's from the East Coast. She's from New Jersey. Like, you stick together. It's, like, we had an argument the other day. I don't think she'll Miami's on this and, like, we got on and we were, like, ready to crap, and we haven't had one of those in years. But I just remembered that at the end of this conversation, we're going to be okay. And at the end, we were closer. So we both have that. And think for her, the fact that there was a complete disintegration of the picture, my sister out of the house, my dad out of the house, and me there she really hit the skids. And home became a very empty very quickly became a very empty and depressing place. It was really It was just really sad. And I found care and love and community in the world of skateboarding. This was the early nineties, and there was this collection of mostly young guys at that time who had aggregated Embarcadero Plaza, Justin Huberman Plaza in San Francisco, I started going up there and hanging out at the it's. Now the famed EMB for it's kind of got a golden era reputation now the famed EMB where it's kind of got a golden arrow reputation now. And that's where I learned that you don't have to go to school. There are a lot of guys not going to school. There was a lot of drinking, lot of drug use, lot of wild behavior, but also I should say a lot of amazing skateboarding. And amazing characters and personalities and fights and everything. It was true street It was true street life. And so I started staying there. I'd stay at people's houses or sometimes we'd even sleep there. And I learned a lot about how people outside the cozy suburbs of the South Bay, how they lived. I'm grateful for that because it exposed me to the fact that many of these kids had no parental oversight from any age that they had to scrap for everything. But quickly, I realized that I wasn't very good at skateboarding. I didn't have future in it. And I wasn't going to and I wasn't going to school, my home life was really disrupted, and I lapsed into a pretty serious depression. I just remember, and anyone who's experienced depression, I I hope this will resonate with. Although, I I'm sorry that it exists, but there's this weird thing about depression, which is that It changes your actual view of the world. I remember leaving Embarcadero sometimes and looking up at the sky. Back then they had the Embarcadero freeway. And thinking the sky is so sad. Like, not the sky as a third as a separate object, but that this scene of the sunset is so sad. And actually yesterday, I was thinking about this because there's this beautiful sunset where I live and I thought, gosh, I haven't felt sad at the view of that natural world in so long. It's and so it's clearly a shift in my internal state. And fast forward. What happened was eventually the school picked up on the fact my high school picked up on the fact that I wasn't going, they called what happened was eventually The school picked up on the fact my high school picked up on the fact that I wasn't going. They called I mean, at some point I was sitting down with a school counselor and they had this guy in the room, me in at some point. I was sitting down with school counselor. And they had this guy in the room with me sitting there. And pretty soon I realized that I was in a different kinda situation. And And I realized they were going to probably try and take me away because I was completely they were gonna probably try and take me away because I was completely truant. I hadn't gone to school. I was clearly depressed. So that's what happened against my will and despite an attempt to run away, I was taken to a place up the peninsula which was neither a juvenile hall nor a psychiatric hospital, but we were under lock and key. And I was in there with kids that had dealt with everything from sexual abuse to hardcore substance abuse issues. I'll never forget this. They said, the kids in the in the ward next door, they're crazy because they're really young. And the adults in the ward on the other side, they're crazy. But you guys, you're not crazy. And I thought, well, that's ridiculous. Because everybody's saying the same thing to the ones on the other side. But I had no one to call. I called my Skateboard team manager out of sympathy, not because I was any team manager out of sympathy, not because I was any good. I'd got put on a on a wheel company and a truck company. For skateboarding and I called guy. And I said, I I don't know what to do. I'm in this place and and he I'll never forget he said, look. I can barely take care of myself, and you're the most normal guy I know. And I've realized at that point, I'm like, I'm really alone here. So the long and short of it was I did the work. I put my trust in the counselors that were there. They seemed like good people. And, you know, I did the work, but it's part of an agreement for getting let back into school. Actually, it's part of an agreement for being let out. I had to do weekly therapy. And I was fortunate enough that I got placed working with somebody who understood my particular needs, worked with adolescents, and really encouraged me to start exploring my mind. Certainly, the situation I was in, but encouraged me to start meditating. He gave me John Cabot's inns book wherever you go. There you are. He saw how much physical energy I had, and he encouraged me to start running. I was always hurting myself, skateboarding, and he said, well, maybe running or swimming and running in swimming are amazing because unless you really do it wrong, you can go and go and go. It's just an I could burn off all that anger and and energy over time. And then I started getting into weightlifting and and the weightlifting is kind of a double edged sword. I should mention think it's one of those things that is great, but you know, if you exceed a certain size, it can actually make people kind of scared to you. Sort of like the tattoos thing. A lot of the like, a lot of reason why I cover up tattoos is because then people just see the see your tattoos. But I it's true. I started getting tattooed pretty young the wrong way. Don't do it this way with Indian ink and a needle. This was before this is autoclaves that. Don't do it. But I decided at that age that the therapy and this one person who seemed to really care about my mental and physical well-being and would spend the time was really worth investing in. And I hid it from everybody because no one did therapy, then no one talked about it. Like late eighties, early nineties, nobody did that. And I will confess, don't think I've ever said this publicly, but I found a way either through insurance or through my own income, I've continued therapy with that same individual now for thirty two years. Wow. And so I do I confess I do three sessions a week of psychoanalysis, remote, or in person. And I know people have a lot of They do the other kind of I roll, not to speak a I roll test, but the other kind of I roll when you say psychoanalysis, I think an exploration of the mind is extremely powerful. It has to be done with the right person. And there's only one person I know who's done this kind of extended work for so many years, and that's the late Oliver Sachs. Who's kind of a hero of mine, also worked with a psychoanalyst for many, many years. And so psychoanalysis a fight on on July fourth nineteen ninety four, a lot of attempt to both stabilize my mind and also organize my behavior. Those things go hand in hand, of course. But also biology to leverage, I guess, you could call it biohacking, you could call it I just Neurobiology. I mean, when I learned for instance that taking a thousand milligrams per day of EPA, essential fatty acids, not just fish oil but getting above that threshold is as effective as antidepressants. In double Lyme placebo controlled studies, you know, when I saw those papers, I realized, well, I probably have a bit of a leaning toward depression. I'm gonna do that. Now did I do that and drop therapy? No, I do that in No. I do that in therapy, and I train, and I try and work on my sleep. It's a constant process, but biology and the information contained in books like yours and and hopefully in the information that I'm trying to put out into the world now, that stuff helps in a major way too. So it was a multipronged support system and many incredible mentors along the way, but I was definitely at the edge. I know you've talked about this public too. I I mean, there were times when I just thought, like, why continue? And I'm fortunate nowadays I feel very far from that. There's a saying in the in the world of addiction and addiction treatment, which is that no matter how far you drive, you're always the same distance from the ditch. That I would say is true of addiction. Fortunately, at least in my own experience, that is not true of depression. I vowed to never go back to a place where living seems meaningless. And anyone who's been close to that place, all I can say is, the work works, whether or not it's therapy, biology, etcetera, you have to do it. And there are things that can accelerate that process, but it's an ongoing battle, to be honest. While you're fighting the good fight, man, I'm certainly right in there with you. How does it feel to talk about this stuff? It's interesting. I always get a little quirky on this. I would say there are only two things that will always consistently make me cry. And and those are the thought of I don't even wanna talk about for too long because I prefer not to cry. But, one, it would be when my Bulldog Costello goes, we're very bomb and he's close unfortunately, so he's in his final years. And the other is when I think about my mentors, in particular, one, passing away. Talking about this gets me in a mode where it's uncomfortable. I'm definitely uncomfortable at this Cogan. I'm okay to talk about it because I think these issues are important, and I wholeheartedly believe that many people struggle with them. You know, I'm always conscious of protecting the people in my life who were doing the best they could with what they had. So, you know, my parents are good people. That generation didn't have the tools that I had access to I do hope the next generation and we'll have access to more tools. So I wanna protect them. They they are, you know, I'm blessed. I acknowledge my privilege. I and I don't say that for political reasons, by the way. I just wanna say I acknowledge that I was born into a pretty fortunate or very fortunate situation. That provided buffers. And I only know my own experience, but I acknowledge it as real. Thanks for sharing all that. And a mutual friend has prompted me to ask about the Hoffman process. Oh, yeah. The Hoffman process. So the Hoffman process is a it's a personal development process. It's a full immersion week long process. I think it used to be two weeks. I don't wanna give away too much about it because if one were to go, you wanna have the experience for the first time. Without expecting or knowing what's coming. It involves a lot of both physical and kind of emotional purging. And what's interesting is it's generally between twenty and forty people go. You don't publicly share any of the issues that you're grappling with. There is a teacher there that you communicate with and who knows a lot about your situation. There's a lot of work that you do beforehand and paperwork, so they really know closely what you're grappling with. And you do get to know people there, but there are strict rules, no romantic relationships, no discussion of politics, no discussion of work, no discussion of sports, and you quickly find that you realize that you spend a lot of time thinking about and talking about those things in the outside world and b, that there are other ways to connect with people that are very authentic. That don't involve those things. Hoffman process was one of several things for me that was transformative For me, it was most transformative in the realm forgiveness. I felt completely resolved of my challenges with, you know, inability to focus complete work, structure, etcetera. I've solved all that. I learned how to work hard perform well. By time I went to Hoffman, which was in my early forties, I'm forty five now. I learned how to control my physical landscape as best as one could or should. I went there thinking, like, why would I go here? What's the purpose in going? And yet, I I realized that I harbored a lot of resentment, mostly toward family members, but also toward experiences and and and people outside my family. And I almost got kicked out of Hoffman the first day, not for misbehavior, but because I slept through the first day, I've been working so hard. They kept saying, I'm trying to escape by sleeping. And I'm like, I'm just tired. Like, they take really good care. They take really good care of you there. I've actually never felt so nurtured I'm not somebody who accepts nurturing very easily. I'd like to think I'm more of a caretaker and a more of a kind of caretaker loner type than being taken care of. And Huberman, I felt comfortable to be taken care of in certain ways. And I discovered in doing the work that there were all these resentments and I was able to purge those resentments. And I have to say, it completely erased all feelings that I was wronged by anybody or anything. And that's powerful. And it's completely behavioral nature. There's no pharmacology there. I would say Hoffman is among the two or three things that were maybe four or five things that were really transformative for me. And there is a price point, but they do have a scholarship program that's been established, thanks to the generosity of various folks. So for people that can't afford price point, they do have a fairly simple scholarship program where you write something out. People who are practitioners, you know, therapists and in the wellness community, I think, also get a break of some sort. I have no business relationship to Hoffman, but I've recommended that several people go and it is powerful and it does last. In fact, the reason I decided to go to Hoffman was because somebody Actually a mutual friend of ours, Tim, who I don't think when? When do y'all them? Who I know from way back when? haven't been in touch in years, but I think said something about Hoffman and she said she knew somebody who went and I contacted that person and that person said I went to Hoffman and ten years later, it still has a profound positive effect on my life, and I found it to be more useful than any other therapy or training of any kind. That's my Hoffman story, and it's powerful. And for people who want to hear more about Hoffman, I talk about it. At at length also with Blake Mykoski in the last conversation I had with him so people can find that that episode. You mentioned one of four or five things. What are some of the other things that have had a disproportionate positive impact? This is a broad category, but get your biology right. Start with sleep. Figure it out. Figure out how to get your sleep right because it's the fundamental layer of mental health. So get that one right. Other things in the biological category are learn how to focus. Learn how to defocus. Learn how to flip the switch on. Learn how to flip the switch off. Get good at sleeping. Of course, exercise of various kinds is gonna be good and all the other things, but there's there's that physical bin and those are the primary levers there. I do think some form of exploration, whether or not it's psychoanalysis, psychotherapy, journaling, or some sort of internal reflection that's somewhat unregulated, but obviously not damaging to you or anyone else. So don't punch concrete walls, but have the ability to sit down and data dump and reflect, if you can't afford therapy, reflect on what you're seeing and reading and feeling. Have the ability to experience what's internal. So that'll be the second one. The third one is and I realize there's some issues around legality and things. And right now, everything's in transition. I was part of a clinical trial, so I can safely say this. You know, I do think that there are certain aspects to let's just call it what it is, either plant medicine or I was part of MDMA, assisted psychotherapy trial that was extremely valuable. There's no question to me that that's a powerful mover of one's ability to feel comfortable in internal state. The way would just briefly just scribe that experience for me is that I could feel and perfectly fine from here to here and from the belly button down, but I had this feeling always that I couldn't kind of experience things in mind and body at the same time. I know this is gonna sound really wacko to people who maybe haven't experienced this, but somehow in that brief experience, I was able to resolve that, and I now experience my nervous system as complete entity. And I do not think people should cowboy this stuff and do it on their own or try and do therapy for their friends or do this on their own. I don't think this is something that people should play around with these are very powerful tools. You should do this with a board certified MD, sign up for a clinical trial. Hopefully, this will be done in the in these sorts of medical settings soon, legally, and you don't have to be part of clinical trial. But if you struggle ongoing in some way. I do think there's utility there. So that's another bin. And then there's another bin, which for me has been very powerful, which is stay on the adventure. Continue to have fun. It's so easy to forget to have fun when you're doing all these other things. Like stay in the adventure and Don't get killed doing it, but, you know, really try and keep exploring. I do believe these dopamine systems are positively reinforced by novelty and exploration. We know that. And by venturing into new territories, and that requires getting certain things wrong. It means going to a retreat that sucks. It means taking a class that is not that interesting. It means finding out that, you know, a particular relationship is not right for you, but it's important to stay in a mode of adventure. Because that's fundamental to the human experience and it's fundamental to these neurochemical systems as well. Couple points I'd love to underscore here. So the biological piece you've discussed in other places, this principle, it's a quote of sorts of Maxim that I think is really worth remembering. And I'm saying that to myself as much to anyone listening. That is you cannot control the mind with the mind. And whether or not there might be exceptions to that, I think, is a general rule using the bidirectionality as you've mentioned. Sort of body, mind, mind body. And when in doubt working through your fuller biology is incredibly powerful. I mean, for me, like, to get out of my head, I need to get into my body. There's just no metacognitive way generally. For me to otherwise do that. Or if there is, it's just much more difficult. I have even told my girlfriend, I'm like, if I'm trying to figure out what is bothering me, and I spend more than, like, half hour on it. Just tell me to go to the gym and lift heavy things for at least thirty minutes. Best rep best remedy in in the world. And then I come out, I'm like, yeah. That that bullshit's fine. It doesn't matter. Right, sir. And that's what was necessary. On the adventure side. Actually, before I get to the adventure side, just a quick note on Casella because I think a lot about my dog molly and mortality, and it's just it's, like, so easy to get sad. And How old is she? She's seven, but she's had some health issues. She's had two spinal She's had two spinal surgeries. And if you haven't looked into the canine research with rapamycin, I would look into that. It's very, very compelling. So that might be -- Thank you. -- I'll do that. I listened to your podcast with Peter Rottia, and -- Yeah. -- a lot of discussion about Rapomycin. I I'll definitely check it out. Yep. It's it's worth checking out. There's also a separate episode with David Sabatini of MIT who is a genius and and it's sort of Emtor wizard who's -- That family. -- his he has a brother Bernardo Salvatini who's a famous at Harvard who I know quite belowAndrew their dad, there's another Salvatini, who was at NYU Med. So those saboteenies. They're not like the Kornbergs. Kornberg discovered RNA. His son discovered the structure of RNA. They both got nobles, and I think their brothers an immunologist, something like that. So -- Yeah. -- if your last if you're thinking about changing your last name, Sabatini or Kornberg is a good one to to select. Yeah. Not not not bad. Yeah. They they come from the secretary at stock for the scientific gene pool. I'm sorry. On the adventure side, so you said don't die or don't let something kill you, which I think is a perfect segue to As I'm reading it from a paragraph from outside magazine, Huberman about forty miles off the coast of Mexico and forty feet below the periwinkle surface of the ocean. What does this refer to? Oh my. Yeah. So before I went to Hoffman, I was still working out some things. The quick backstory of this is in twenty sixteen, I decided I was gonna shift a lot of my laboratory work toward humans. I understand the issues of animal research and why it's important. My lab still does work on mice because there's certain things you can only do on mice, but I I wanna work on humans. And I want to use virtual reality to induce fear in the laboratory and study stress and fear in other brain states. And we realize that VR as it stood at the time was just pretty lame. It was computer generated images. It didn't have three sixty video or sound. And so I got linked up with a guy named Michael Mueller, MULLER, who's a very very famous photographer in Hollywood, mostly. Does all the Marvel stuff is shot everybody that you just can go to his website. It's just it's kind of a just a constant scroll of iconic images. Mueller and I got to be friends And the reason I was excited about getting to know him is because a hobby of his is that he takes photos of great white sharks. Under water. He brings these giant strobe lights, underwater, and Mueller is, you know, you hear about the character of the Wolverine Hugh Jackman, He brings these giant strobe lights underwater. And Mueller is you know, you hear about the character of the Wolverine Hugh Jackman. Right? Mueller is a Wolverine. He's kinda hunched over, and he's the nicest guy in the world. But it was like, it was immediate friendship. But he loves adventure. He's got He's got a family, kids, everything, but he loves adventure. And he said, this is my best molar personation. He's like, bro, you gotta come down to like, bro, you gotta come down to Guadalupe. The sharks are the structure there. I was like, well, what are we gonna do? And he said, well, we'll just film them with three sixty cameras. So in twenty sixteen, we went down there and we filmed great white sharks as a stimulus for this fear laboratory that we were building. And got three sixty video. And the way we did that was that Mueller and a couple of other guys, these expert, great white shark divers would leave the the way we did that was that Mueller and a couple other guys, these expert, great white, sharp divers would leave the cage. You lower the cage about forty feet belowAndrew leave the cage to come back in. So called cage exiting, definitely illegal to So called cage exiting. Definitely illegal to do. We got permits from the Mexican government because this was for a scientific study. I would have loved to see that permitting process. Anyway, continue. That was something else. So we we we got the footage, brought it back, built this thing up, and then what happened was in the subsequent year, the technology for VR really improved. We decided we were gonna go back. And I decided for whatever reason that I was gonna cage exit also. I actually learned how to scuba dive for the first trip. But I had stayed in the cage. And so the second trip we went out there and I brought a good friend of mine who was actually a mutual friend through Blake Mykoski, Pat Dawson, is a former former steel team guy. I brought Brian McKnight because Brian learned Brian McKenzie now had a scuba dive in a lake. In Cogan, and his first Cogan dive was Kjexit with great whites. I guess. Now, of course, the guy has unscared tattooed on his knuckles. I know he was featured in in a number of your your books. So as Brian, Pat, me and some other guys, we went out there with the intention of getting better footage. To create a very realistic VR experience of great white sharks. So what happened was on the first day, I decided, I'm not gonna cage eggs at today. Wet Pat go. He's the steel team guy. He'll do it. He did it, of course, masterfully the first time, went a few meters beyond everybody because Those guys aren't competitive or anything. Anyway, it all worked out. But the first day, I was in the cage. So I went down. I'd been in the cage before, and you're breathing off a hookah line, which is up 2017 the surface. You're not on scuba. And the reason you don't bring scuba is because you don't want to take up too much space in the cage. So the other divers, Mueller, and a couple other guys had left the cage. And I was there just watching the sharks and really enjoying it. I'd been down there the previous year. And these great white sharks, their girth isn't incredible. And they come at you like a Volkswagen they'll stop right in front of you hover. They'll eyeball you and then disappear into the darkness. So does it's really amazing. And I realized as I was down there, I'm like, I'm alone in the cage this time. I've never been alone in the cage. We had a lot of sharks that day, so I was moving around and swiveling around a lot. And then all of a sudden, had no air. Nothing. Just nothing coming through the mouthpiece. And I looked up and the Kukuline got all boa constricted up. So I popped up to it thinking, oh, just untangle this thing and it's like hardest concrete. It's like, oh, good. So I took another suck of air and nothing. And I looked down their safety tanks in the two corners. So I spit out the mouthpiece, I drop down in the safety tanks, open them up, and the needle doesn't move. They're empty. Oh, god. This is like the biggest nightmare. And it's interesting when we were talking about Castillo, I had one thought at that moment. A totally inefficient use of mental space, but the one thought was I'm going to go home, alive. I'm going to see I'm going to see Costello. He just popped into my head. So this stuff really does happen, apparently. So nothing off the safeties, tanks. So I decided I gotta get out of here. Well, there's sharks everywhere, but I've gotta get to the surface and you're just desperate for air. So I pop up to the top of the tank and I've got a weight vest on and I've got to take that weight vest off if I wanna get up to the surface. Now the sharks actually don't eat you when you're outside the cage if you're swimming toward them, they actually if you loom on them, they steer away. That's the way that these KJ exit divers are able to avoid getting eaten. Or if you're Ramsey, you just kind of understand them and you swim next to them. But I was genuinely frightened and stressed, and so I thought, okay, I'm gonna shoot for the surface. I could see the silhouette of the boat. I'm gonna shoot for the surface. I'll either get eaten or I'll drown, but I'm certain I'll drown if I stay here. And then what happened was one of the divers, his name's Brock, saw me, and started kicking back toward me. And he's carrying this big vacuum, cleaner And he's carrying this big vacuum cleaner size VR thing. And that felt like an eternity. You know, he's coming back to me. Back me me slowly. So now just hoping if I pass out, I wanna fall into the cage. If I float, I wanna make sure I float up. But it was a good twenty or thirty more seconds. Doesn't sound like very long, but it's not like a that sounds like an eternity. Yeah, there was an was eternity. So he made it back. We did the share error thing. But then we had a whole other problem, which was that we're sharing air. Those guys are out there. We're now on We're now on one tank. And the safeties are empty. So now there's a chance that we both might have to shoot for the surface. So fortunately, everybody made it back in time And we got up to the surface, but I will never forget that we got up to the surface. But I will never forget that experience. I do feel like I'm on borrowed time and I did feel quite traumatized by I do feel like I'm on borrowed time. And I did feel quite traumatized by it. And I will say that that night I did one thing and the next day I did something else was McKnight, I I was able to sleep. I did yoga Nidra, and I was able to calm my mind and my nerves. And the next day, Because I I understand a bit about the relationship between trauma and exposure, I did go back down the very next day and I cage exited. And some people might think that's foolish. I certainly didn't do it to tough or does seem like I'm tough. I did it because facing the trauma is the best way to purge the trauma. We know this. And cage exiting for me allowed me, I believe, to report the experience, I feel nothing in my body, no tension, no stress, no quaking or anything related to that. I do think it's been completely purged. I wanna dig into what I read as definition of fear from you and just to hear more about your fascination with fear and where it comes from. So here here's what have, and you can fact check this, please. Quote, fear. It's the anxiety that you feel when you don't know what behavior can remove a feeling of helplessness in the face of a threat. End quote. Does that sound right to you? You can't have stress without You can't have stress without anxiety. You can't have trauma without stress, but you can have stress or anxiety without trauma. I think that the key variables are anxiety is a state of heightened alertness. Contracting in the visual field, quickening in the heart rate, breathing, all the kind of standard stuff that we hear of sympathetic nervous system activation. But The mental component is one in which time is being sliced very finely, so you're constantly anticipating and evaluating your environment and your internal state. Because oftentimes people are aware of their so called interreception. They're keenly aware of how nervous they are or upset they are. And this element of uncertainty of being unable to predict when it's going to pass. And this creates a kind of meta stress sort of like when people have trouble sleeping, then they create this kind of meta anxiety and insomnia. They're now they're stressed about not sleeping and so then it makes it even harder to sleep. The same thing with stress. The more we stress, the more we want the stress to pass. And I think that resolving the uncertainty element is powerful and I think it starts by taking control of the mind through the route of the body. When our mind is not stable, whatever that means, but we're not able to control our mental state or it's not where we'd like it to be. We need to look to the powers of respiration, of vision, of movement, of weight training, of running to reorient the mind. I think it is futile to try and rescue thinking with thinking. That's not to say that thinking in an exploration of the mind like with psychoanalysis or journaling is not powerful, but for restabilizing our system, these brain states of mind and body, I think the body is the more powerful entry point. And have you always been fascinated by fear or why why did that become a focal point? Probably because I was the kid that was last to drop in on the ramp, probably because I have lived in existed with a fair amount of because I was the kid that was last to drop in on the ramp probably because I have lived and existed with a fair amount of fear. This seems to have gotten better over the years. For instance, I can remember skateboarding home. There's this bike path that used to connect, the school that I went to, the back of some houses, and I would push back through there at and I would start to imagine that terrible things were gonna happen to me. I think that fear was a was a strong default. And I can't assign that to any earlier experience. I think I just had a lot of baseline anxiety and fear. And so resolving that and figuring out tools that people could use, that I could use, also to resolve those things really fast has been a major a major effort in my life, including my laboratory. I'd like to, if it's okay with you, shift gears little bit and just pepper you with a bunch of random questions that have absolutely no continuity with anything we just talked about. Right. That's okay. Sure thing. Alright. Because I just I have this sort of scratch pad full of these various things that I wanna ask about often without a whole lot of context. Just from from various reading and so on. So turmeric's effects on DHT -- Mhmm. -- could you elaborate on this? So to die hydro testosterone, I'm guessing. Yep. What should we know about DHT and turmeric's effects on DHT? And I ask in part because it's something that I use all the time in cooking. There seems to be some research to suggest that products like TheraCumin, I believe it's called, there's a brand name. Might attenuate some risk related to say neurodegenerative disease or Alzheimer's. So I'd love to know more about this. Yeah. So brief endocrinology lesson on testosterone, DHT testosterone is the So brief endocrinology lesson on testosterone, DHT testosterone is the Androgen, of course, that's responsible for muscle growth deepening the voice, aggression sex drive, etcetera. But DHT dihydrotestosterone is made from testosterone through an enzyme called five alpha reductase. DHT is the more powerful androgen anywhere from three hundred to six hundred times the affinity for the androgen receptor. DHT is the and its affinity for the androgen receptor Not so incidentally is the basis of mandrelone DeCA known in Jim Circle. It's actually a female runner that was a good pick for the fifteen hundred, just got a four year ban. Oops. Or a stand alone positive test. She claims and her coach claims that it came from a burrito containing pork with mandrelone. I actually would love somebody to go. We're gonna see more of this in the years to come. I'd like somebody to actually analyze meat for clambudoral and answer alone to just see because I they and I'm not happy that this happened or it's a sad situation, but We could fairly say that there's been a dark shadow cast by a burrito over the Olympic qualifications. Scott, like, when when all the sprinters were diagnosed as narcoleptics, you remember that with -- Oh, really? -- medafinil. Yeah. They're all on medafinil on various stimulants, and so they had these scripts from their doctors and letters saying they're all narcolepsy. It's just amazing. The Venn diagram to get them quick out the blocks. That's where the race is won. Hear that and get out the blocks. That's so nandrolone is That's So, Nandrelone is DECA. The reason people take it, whether or not she took it or an IONO, but the reason people take it is because DHT as the more powerful androgen with this higher affinity is the one that's mainly responsible for libido and many of the cognitive effects of testosterone. One of the more powerful effects of testosterone is that because of the fact that there are androgen receptors in the amygdala, that it has a fear suppressing component to it. And DHT testosterone, but really DHT has a property of making effort feel good. That's probably the main psychological effect of testosterone aside from its effects on on libido and the body periphery. So some people are very DHT sensitive. If you're somebody for instance that takes creatine and experiences hair loss very quickly. You're probably DHT sensitive. That's because creatine increases DHT. DHT will promote hair loss on the scalp, like my hair lines retreating quite nicely now because of DHT receptors here, and it promotes beard growth. So has these inverse effects on the face and on the scalp. But turmeric is a fairly potent DHT antagonist. Now whether or not it does that by occupation of the androgen receptor or some other mechanism, I don't know, people will vary in their sensitivity. I am very sensitive to turmeric. If I take turmeric, my DHT levels plummet, and I'm not taking nangilone nor am I eating pork burritos. But the the sensitivity will vary. And you can kind of predict that sensitivity by how you react to vary and you can kind of predict that sensitivity by how you react to creatine. If you're somebody that takes low doses of creatine, which many people do and experience hair loss, chances are when you take turmeric, you're going to see a reduction in DHT. Means that your five alpha ductase system and or this interaction between turmeric and the androgen receptor are for whatever reason more sensitive in use. Some people take turmeric and feel perfectly fine. I noticed an immediate blunting of all the good stuff, let's say that DHT and testosterone do when I take even minimum of turmeric. Now that doesn't mean I can't have a little bit of turmeric in a drink, like a juice drink or something. But dosing turmeric is not something that I do or that I recommend for people. Now women do make a little bit of DHT McKnight be a whole different story with them, but I I think for men, you you probably just wanna do the experiment. It's quickly reversible if you stop taking turmeric so you could evaluate this. Some people will be fine. You could do a blood test, you could do it subjectively. Is finasteride, Propecia that is often used for mitigating hair loss. That is I think it's a five alpha reductase inhibitor would that also have the effect of decreasing DHT levels? I wanna say they're anecdotal reports and people please do your own homework, go to go to pubmed and do some research. But I want to say that at least among strength athletes that I've heard anecdotal reports of Propecia use correlating to decreases in strength gains for male athletes? Yeah. absolutely. And it certainly can reduce DHT And it certainly can reduce DHT levels. Certainly more for those that are sensitive to it. Just to underscore how powerful DHT is, we have what are called primary and secondary sex characteristics. Secondary sex characteristics. So like body hair deepening the voice, et so like body hair, deepening the voice, etcetera. But the primary characteristics, like the presence of a penis or not. And this is independent of gender. This is just biological sex. It's encoded by the Y chromosome. That's entirely controlled by DHT during development. And masculinity of brain is a separate pathway. But there's this phenomenon that I think is in the Dominican Republic, a genetic disruption in some of these pathways and there that people can look this up, the so called, who have doses. This is a famous story in endocrinology of children that look female at birth by genitalia and then because of a surge in DHT later, they literally sprout a penis at about end testicles descend at about age twelve. With the doses. Wow. And there's a whole story there. It actually was part of the story that helped neuroendocrinologists and developmental just understand the role of five alpha reductase in testosterone's conversion to DHD. Fascinating biology there much, too much going to now in detail, but people can look it up online. DHT is powerful in development and it's powerful throughout the lifespan. So you you want to keep levels of DHT appropriately high. But don't take Nancy alone if you're sprinting in the Olympics. So that's not the way to get your manager loan is not the way to get your DHT. Yeah. Even if you do get it through through anabolic piggy's, Just like there's so many more cost effective ways to make pigs grow. DeCA. Dravelin injections is probably not high on the list. They need nati menus. Right? They need menus that are, like, if you're Olympic athlete, please just prepare your own food. Yeah. Yeah. Exactly. So so many directions to go here. It makes me wonder also if anyone has looked at turmeric or cocumen or whatever the actual compound is responsible for this DHT inhibition, whether it's via five alpha reductase or otherwise on pregnancy. And birth gender. I'm wondering if that would have any effect if DHT is pressed in a woman who is pregnant if that would have any effect. On Earth's gender. Yeah. That's a topic that don't think the experiment's ever been done, but my post doc advisor, Ben Berris, was transgendered. And it's an interesting story, briefly, he was an identical twin. He, from a very early age, he felt entirely uncomfortable in a female body. He knew he wanted to be male from a very young age long before puberty. His sister who I've I've interacted with as well is perfectly happy being a Cogan, enjoys being a and they're identical twins. And their mother was actually treated with an androgenic drug during pregnancy. Then, unfortunately, passed away of pancreatic cancer a few years ago. He's an incredibly accomplished neuroscientist and physician. His name is Berris, BARRES. There are number of obituris. I I wrote one for nature that, know, describes his life and his transition and some of the biology. But nonetheless, Ben and I spent about a year before he died, I recorded a lot of conversations with Ben that haven't released yet talking about what it was like to be a girl, what it was like to be a woman, what it was like to be a man later in life. Just as I he's a close friend of mine. I want to understand that. And he described that this was an immediate effect As soon as he knew there was a difference between boys and girls, he knew that he was in the wrong body. He he likened it to, if he woke up tomorrow and you were in a gorilla's body, that's how uncomfortable it was knowing that that's how he described it. And he thought that perhaps, you know, this early endogenic drug treatment might have shaped his brain differently than his sister somehow. Hm. Raises so many, so many interesting questions about, you know, phytoestrogens or soon as these Xeno estrogens and the environmental inputs that could affect that entire biochemical cocktail to different different outputs is this so many so many interesting questions about you know, phytoestrogens or sort of these zenoestrogens and the environmental inputs. That could affect that entire biochemical cocktail to different outputs, testosterone So we've talked little bit about DHT. There's a Goldilocks range depending on your gender and your objectives for testosterone. Are there any particular supplements that you use to I hesitate to use this word because it's so gold dependent, but optimize your testosterone or DHT. Levels or reduce sex hormone binding globulin or whatever. If you're sort of toying with your androgens, how do you like to do it? Optimizing and or or understanding testosterone, I think, is is vital for men and women because it's so powerful Obviously, get your sleep right. That's an important one and you do that through so that's an indirect effect. Stress, keep stress, chronic stress to a minimum, that's an indirect effect. Train hard but not too long, that's an indirect effect, mostly. In the supplementation space, there are two things that have worked very well for me. And that I've recommended to a number of people that have worked well for me and that I've recommended to a number of people that have worked well for them. And those two things are Tomcat Ali, which at four hundred milligrams per day is thought to reduce sex hormone binding globulin because of those that don't know testosterone can exist in a free or bound form. People here binding globulins and they bind up testosterone and prevent free testosterone. They think this terrible, but actually albumin and sex hormone binding globulin are wonderful because they ensure that whatever testosterone you make will be delivered to your tissues over a long period of time and different tissues need different amounts of testosterone. And so you don't want to plummet sex hormone mining globulin, but Tonga Ali either through reducing sex hormone binding globulin or through direct effects on increasing androgen release. Will increase your testosterone. Now the way to explore this, and I'm not saying anyone should do this, you definitely wanna work with your physician. But the way to explore this is four hundred milligrams per day taken once per day early in the day because it can have a little bit of stimulant effect, making more alert that works well. It does need to be taken chronically. It tends to work better as you get into the second and third month of use. And I don't see any reason to cycle it unless somehow something's, you know, spikes on your liver enzymes or something. The other supplement that is quite useful is Fidelity Agrestis. Fidelity Agrestis is one of these plant alkaloids that think that comes from a Nigerian shrub. I might have that wrong, but but docioegrestis acts as a luteinizing hormone mimic. So it actually stimulates the testes to produce more testosterone. So it's like HCG. It's like a It's a bit like HCG, but it for whatever reason it doesn't seem to increase estrogen, which is unique because HTG will increase estrogen. Now just anecdotally, I started using those in combination. So it's four hundred milligrams of Tonga Ali. I have no relationship to the company, so I can mention where I get it from, although I hope they don't sell out as I will start out as consequence. A solar a makes a good version of this. Sometimes these things are packaged in with other things, but solar a has a pure form. And then fedogia ingressis, think it's herbal elixirs makes a a fedogia ingressis. And some people make the mistake of taking far too much fedogia ingressis. I think on the bottle they recommend three two to three times a day, one four twenty five milligram capsule, I believe is more than sufficient And anecdotally for me what this did is it it increased my total testosterone by about two hundred points. So I've l kind of in the middle of the range. I was neither high nor low. I was at about six hundred, hovering somewhere around six hundred. These two supplements consistently bring it up into the high 7s or low 8s, which is in the direction that I wanted to go. Do you think for dojo aggressiveness, if it is luteinizing hormone, similar, meaning it's a mimic of Do you think Fidogia regressed us if it is lutinizing hormone similar, meaning it's a mimic of sorts. Do you think that would have any guess it probably would have a sort of down regulating effect on endogenous production of l h. Well, what's interesting is when I've done my blood work twice a year, at least for me it did not down regulate l h, which is nice because things like HCG definitely would down regulate l h, people who take testosterone, tipionate, you know, so called TRT, or similar, we'll see a down regulation in lutinizing hormone. So, Fidochia and Tonga Ali, I I mentioned because there's sort of an intermediate between doing nothing with respect to supplements. Or taking things that don't really work. There are a lot of those out there, or taking the full plunge into TRT. And I'll just mention, if I if I may, about TRT, there's a lot of interest and excitement in TRT. They now even have what's called sports TRT, which is not just for people who who don't have the context, if I'm not sure if you if you already kind of named it out, but testosterone replacement therapy, TRT. So Right. What's what's sports tier? Is this like MedSpa type stuff? Yeah. So people are probably wondering, wait, you're a neuroscientist. Why do you know so much about this stuff? Well, I have the good fortune of doing work with various high performing communities and there's just a lot of discussion around hormone and neural augmentation. And so I'm not making recommendations. I what I generally do with those communities and what I'm doing now is point people to the fact that they're there are things that lie somewhere between doing nothing and going the prescription drug route, eating pork burritos, Yeah. Exactly. exactly. In the realm of TRT, testosterone replacement therapy, the typical dosages that people use are 160 to 200 milligrams a week, but the way it's administered doesn't match the In the realm of TRT testosterone replacement therapy, the typical dosages that people use are a hundred and sixty to two hundred milligrams a week, but the way it's administered doesn't match the biology. I think this is a serious problem that needs to be dealt with. Typically, if you get a prescription, you'll go in, they'll give you one injection of anywhere from one hundred and sixty to two hundred milligrams and then you go back two weeks later and you get another injection. The testes normally make anywhere from about five to ten milligrams of testosterone a day. So if you're taking a hundred and sixty milligrams of testosterone on one day, you're going to set in motion all sorts of cascades of aromatization and estrogen conversion into DHT that you might feel terrible then, great four days later, and then so so, two weeks later. The way people are doing this now more intelligently is to do their injections at home, either into subcutaneously or into muscle, and every third or fourth day to take low dose of maybe forty milligrams and to dose it more evenly because these long lasting forms like Cipionate do release over time. But sports TRT is this intermediate that's been created on the Internet where people are neither doing testosterone replacement therapy to get levels up to normal or high normal, nor are they doing what the gym rats call blasting. They're not taking 345 hundred. They're taking two hundred a week or three hundred a week. And the amount of self directed pharmacology that's happening out there is pretty incredible. And look, I don't pass judgment. Everybody, it's your life to live, but there are lot of horror stories too. You can really mess yourself up by getting androgen levels too high. I'm a fan of gently moving into the supplementation space for this, seeing how it works, doing a blood test, And then if people wanna do TRT over time, that's certainly they're right. That's not my place to judge, and you need a prescription anyway. Yeah. I'll talk to a doctor. Yeah. And just a couple of additional thoughts on all of this stuff. Well, well, first, the lower dose higher frequency regimen can also be applied to many things. Right? Growth hormone would be another example from the same sort of portfolio of interventions slash augmentations that a lot of folks would use. And separately, I would say and please please feel free to correct me your fact check on this. But whether you're eating pork burritos, injecting yourself with anabolic of different types or eating deer, antler, velvet, or whatever the latest fad is that people claim increases testosterone. If you dramatically increase your testosterone levels, if you are not taking an anti aromatase, you are also going to increase your estrogen levels, even though it depends on the anabolic, obviously, and nadrolin is very different from different types of testosterone and so on. Which some are more anabolic, some are more androgenic. But if you suddenly wall up yourself with much higher levels of testosterone. You are also going 2017 portion of that will be converted to estrogen. And so it's just something to be aware of. Right? You it's it's very hard to get biological free lunch. That's right. And if you're if you're feeding yourself bunch of stuff, and your testes like the Siberian what were they albino rats? Does does that have hamsters? Yes. Siberian hamsters. If your if your balls go from whatever your comfortable ball diameter is down to, like, raisins, you may require post cycle therapy, PCT, various drugs to successfully off ramp from these types of interventions, unless like some power lifters, you're just going to be loaded all year round, three sixty five, twenty four seven, which is obviously your your choice if if you wanna do something like that. But suffice it to say, I'm glad you could yeah. Good idea to get medical medical supervision for all of things. Definitely. And and along those lines, I should just mention, well, I will say that Fidelity tends to have the opposite effect on the testicles. It actually will cause it fairly not pronounced, but it increases testicle size. That's a pretty strong effect or media effect of of fedotia. The other thing is that right now, there's a lot of excitement about peptide. People are like, oh, yeah. The so called secreted dogs. It sounds like synagogue, but it's secreted dog, which these are, like, not not taking growth hormone, but taking peptides that promote growth hormone release and then people are taking, you know, gastropptide this and here's the deal. Things that make us feel more vital like testosterone, DHT, growth hormone, generally will shorten your life. I know that's a bit of a controversial statement, but if you step back and you just ask yourself, what is the most vital energetic phase of your life? It's puberty when all these hormones are really high. And puberty is the most rapid period of aging that any of us go through. I was talking about this recently with longevity researcher and I And it's kind of interesting that all the longevity, the attempts at increasing lifespan are like starving yourself, which is catabolic. Reducing blood sugar, which is catabolic. And that's on the opposite side of all these things like testosterone, which is anabolic. Insulin, which is anabolic, growth hormone, which is anabolic. And so anabolism sounds like a great thing, though it does sound remarkably similar to cannibalism, but growth and vitality, libido, strength, etcetera. That all sounds wonderful and in its proper form and context is wonderful. But the reason why I think we see people dying early, who do a lot of growth hormone and testosterone is because they've effectively created a third and fourth round of But The reason why I think we see people dying early who do a lot of growth hormone and testosterone is because they've effectively created a third and fourth round of Huberman. accelerating aging. And so I think vitality and longevity always have to be balanced with one another. Totally. And we could go for hours just on this month topic. One other cautionary note well, two, actually. Number one, unless you're type one diabetic, don't inject insulin. There are athletes who do this, but you can very easily kill There are athletes who do this, but you can very easily kill yourself. The second is if you're taking a lot of growth agents, some of them are not selective to skeletal muscle tissue. And you may as a male end up looking like you're in your second trimester from enlarged Cogan. And guess what? When you get off of those drugs, your organs don't automatically resume their smaller size. This is also why certain baseball players and so on have gone up multiple helmet sizes. It's not from pork burritos. Those effects are durable. You can't just hit undo on those things. So very very good points. PACE to be cautious. Alright. So 2017 a a few other things, cognitive enhancement or cognitive boosting supplements, much like the testosterone playing field. There's a clown car full of ridiculous propositions. There are of course then the prescription and medical route where there are certain things that'll help. Some things like nicotine can be tremendously effective but come with some possible downsides associated. Do you have any particular thoughts on cognitive enhancement or how you think about that specifically on the pharmacological supplement side? I know there are many other things that we Cogan also talk about. Howard Bauchner: Yeah, I'm glad you mentioned it. Many other things. I won't list them out again, but I do believe that the most powerful nootropic and cognitive support is going to come from quality sleep and a hundred percent, you know, so it's night and day on the pharmacologic I won't list them out again, but I do believe that the most powerful neutropic and cognitive support is going to come from quality sleep and Yeah. A hundred percent agreed. Yeah. So McKnight and day. On the pharmacologic side, I I think Alpha GPC has real effects that are supported by quality peer reviewed studies, including some studies looking at offsetting age related cognitive decline. So generally, it comes in capsule form of three hundred milligrams or so. I think taken occasionally or more than occasionally provide it fairly early in the day. It does increase focus without increasing the kind of sympathetic arm of the nervous system make other words, without increasing arousal and alertness too much. So I do think AlphaGPC is a useful supplementnbspTheragunnbsppercussive use it from time to time. If I've slept well, I don't take it. If I really want to push a workout hard or work session, a writing session, or data analysis session hard. I'll take three hundred milligrams of that and drink a couple espresso or drink some latte. And some water. Stay hydrated. Hydration is a big one for cognitive function, and it's one that people often overlook. But the simple rule is that This is what I call the Galpen equation because Andy Galpen who's a great exercise. Physiologists came up with this for physical work, but it turns out to work for cognitive work too, which is that Basically, your body weight and pounds divided by thirty will give you the number of ounces of water that you should drink about every twenty minutes. When exercising or doing mental work. Might seem like a lot. There might be an extra trip to the bathroom or two, but it's worth There might be an extra trip to the bathroom or two, but it's worth it. Dehydration is a subtle but very pernicious creep, where you start having a hard time focusing your eyes, you you just feel like you want to go to sleep. That hydration factor is real. So, drink plenty of fluids, especially if you're ingesting caffeine, which, of course, this is diuretic. My personal favorite vehicle for caffeine remains Yerba mate. I just absolutely adore the effects of your romati. I'm not saying it's for everyone, but you have the caffeine and I might be getting the pronunciation off. You also have a belief Seattle saline, which you would find in green tea and theobromine which you would also find and say dark chocolate side note trivia for folks Theo bromine from Theo as in theosophy Theo, Broma food of the You also have a belief theophylline, which you would find in in green tea and theobromine, which you would also find, let's say, dark chocolate. Side note trivia for folks, theo bromine from theo as in theosophy, theo broma food of the gods. So that's kind of fun. Yeah. But the pharmacokinetics of those are all different. So unlike coffee, which I I have a love hate relationship, with because I metabolize it so quickly that I get this this sort of snickers bar sugar high of caffeine for very time, twenty or thirty minutes. And then my baseline of sort of subjective perceived energy is lower than when I started. So what happens then? I become a crack head who drinks, you know, eight cups of coffee a day, not so with Yerba latte, especially when you're kind of titrating it in, in the way that they would consume it in a place like Argentina or UWA, where you're just kind of sipping it slowly, I become a crack head who drinks, you know, eight cups of coffee a day. Not so with Yerba Monti, especially when you're kind of titrating it in, in the way that they would assume it in place like Argentina or Uruguay where you're just kinda sipping it slowly. It's great stuff. I found a brand that I don't have any relation to them, but I found one that I particularly like. It's has a weird name, but it's Anna Park. It's an organic and a part of Amate. I don't know who Anna is or her Parker. Maybe her name is Anna Park, but it's nice. It has the right amount of that tobacco flavor, but it's not burnt to the point of feeling kind of overwhelming. The other thing about caffeine that's kind of interesting is that most people would benefit from waiting ninety minutes to two hours after waking to ingest their caffeine. The way caffeine interacts with the adenosine receptor. Remember, you get sleepy because of time of day with that poll circadian clock mechanism, but also because of the buildup of adenosine in your system. That's the sleepiness factor, really. And when you wake up in the morning, if you immediately compete out any residual adenosine, you lose the benefit of that cortisol pulse. Essentially clearing out the rest of the adenosine. And so a lot of people, despite the pain of having to do this the first day or two, feel much better throughout the day, less of that cracked out kind of rise and crash feeling on caffeine. If they delay their coffee or latte, or about ninety minutes to two hours after waking. Oh, that's great to know. Side note for people who may wanna do some some further research and reading into caffeine. The name Roland Griffiths has come up multiple times on this podcast. He's an incredible scientist and researcher based at Johns Hopkins, who's he is one of the most, I would say, esteemed researchers alongside St. Matt Johnson, Roland, has just been added for longer. With respect to psilocybin and psychedelics. So he's associated with that. But prior to psychedelics, he was one of the world's foremost experts in caffeine metabolism. Mhmm. And so he is he has published and performed studies related to caffeine that are intensely interesting. So for people who who wanna dig deeper into that, Roland is Roland Griffiths is a great resource. One thing I've been wondering, because there are drugs that you can use to counteract other drugs. right? So if you go to Bellevue and you're at the psych, ER, and someone comes in just high out of their mind on cocaine, So if you go to Bellevue and you're at the Psyche and someone comes in just high out of their mind on cocaine. Right? There are medications they could be given to try to take them down a notch or two or three or ten, the Callidol or Not sure if that's used any longer, but there are many different drugs that could be used. In the case of caffeine, let's just say, someone named Jim Berris, just for sake of argument, is working on his laptop at a restaurant and said restaurant, has excellent service, which means they also have the never ending cup of coffee. And so before he knows it, he's had five cups of coffee even though he only ordered one coffee. Is there a way to reverse or counteract the effects of caffeine on adenosine such that you can actually get to sleep? So if you hit the golf ball and you're like, fuck. Looking at the half life of caffeine, there's no way I'm getting to sleep until, like, three in the morning. Is there any way to address that? Or is it just fade a couple and you're more or less screwed? Yeah. One direct and two indirect. The direct way to do that is increase your glucose. You know, the whole notion that you can soak it up by eating some bread, you will see a blunting of the stimulant effect. Now whether or not that's also due to some, I don't know, increase in serotonin or something from the the carbohydrate isn't clear, but, yeah, you could have bagel or two or whatever it is that you're the compatible carbohydrate. These days, carbohydrates are such a complicated thing for most of you. I like carbohydrates especially late in the day. I do the either fast and go low carb, no carb during the day because that lets me focus and that's a meat and salad during the day or not. Eating for portions a day. And then at night, I eat pasta and rice, and I eat very little protein sleep like a baby. That's what works. But the other way is to take theanine. So before we were talking about theanine in reference to pre sleep supplementation thirty or sixty minutes before sleep, but a hundred to two hundred milligrams of theanine will take the jitters out of a caffeine experience. And in fact, so much so that a lot of energy drinks now are starting to include theanine as an attempt to get you to ingest more of those energy drinks. Because they understand that at some point people hit threshold and they feel so wide eyed and wired that they're not gonna consume more. So they they're tricking you this way. And it does indeed way and it does indeed work. The other thing is, if you ever really need to sleep, I mean, again, be cautious, do what's compatible with your physician's advice. But gaba, you know, you can buy gabbo and glycine in capsule form. So a gram of gaba, a gram of glycine in combination, that's more of a heavy hit over the head. But if you're having a hard time getting to sleep. That can help. I don't recommend people take those chronically because GABO of course is a neurotransmitter. And I don't believe really in taking things that are very close to the actual thing that you're trying to manipulate. For instance, I'm not a fan of taking L-DOPA why would I do For instance, I'm not a fan of taking El dopa. Why would I do that? I don't have Parkinson's. But people will take makena Purines, which is essentially ninety nine percent altopa, and you'll get really, really elevated, but then you'll really crash for a day or two. So I think that pulling on the marionette strings a little bit from distance is better than taking the specific compound that you're trying to replace unless there's a clinical need, of course. One more topic and since we're at about two hours and thirty. We'll we'll wrap up in just a little bit, but the vagus nerve. What is the vagus nerve? What is the latest and greatest? Why is it of interest? Yeah, so the vagus nerve is a nerve So the vagus nerve is a nerve network. It's many nerves. It could even be thought of as its own major branch of the peripheral nervous system. It comes out of the brain basically and connects to all the organs of the body. And this is the pathway by which a mental state can influence our digestion, our heart rate, our breathing. We talked earlier about HRV, heart variability. The vagus is an important component to the slowing down of the heart rate when we exhale. It's a very important pathway and it's bidirectional. So the organs of the body that I just mentioned, the lungs that got the heart etcetera, the spleen. They also send nerve connections back to the brain. And there's been a lot of interest in the vagus as a purely calming system. And that's simply not true. The medical textbooks call it appropriately cranial nerve ten. It's in the parasympathetic arm of the nervous system, which suggests that it's all calming, but actually it's not. It has branches of it that are kind of stimulating as well. So in the kind of wellness and self help community, you hear, oh, you know, you should do this thing of rubbing in front of your ears. That's a branch of the vagus that calms you down, or stimulate the vagus to calm down. Now in neuroscience laboratories, And even in some human neurosurgery laboratories, the way that you get people more alert, in fact, a form of depression treatment is to stimulate the vagus and it makes people more alert and more positive and excited. So vagal stimulation can easily cause increases in alertness. How do they do the stimulation? This is a beautiful story. A colleague of mine, perhaps, at least to my mind, the most impressive Neurobiologist. I know a guy by the name of Carl Deyseroff, he invented discovered and invented general red options, which are these from algae essentially, that are light sensitive, clone the genes You can put those genes into neurons, you have to do this by viral injection, and then you have a little blue light diode that will allow you to stimulate just those neurons locally. Carl is a psychiatrist, a bioengineer, and a neurobiologist operating at the very highest level. Actually, there's a book that he just published that I'm listening to now that is It's just Can only be described as only be described as beautiful. It's a description of the landscape of psychiatry and his attempts to build tools that are better than drugs to manipulate the nervous system. It's called projections. And it's a beautiful read. You'll learn ton of neuroscience Carl is well on his way to win every big prize in science. He's got all of them right now except the last one. And I'm not on the committee that votes for those but he's remarkable. Also has five children happily married. I mean, it's like one of these. His wife is a phenomenal scientist and physician. These people are one of the reasons I like being at Stanford is because the mean is so very high, but Carl shifts the mean like he's that dot way out there. In any event, Carl, there's a beautiful article that I can reference, send you the link to in the New Yorker, where Carl is sitting there talking with his patient and she has suicidal depression. And she's describing her lack of desire to live. And then he cranks up the intensity on this stimulation of the Vegas. And in real time, she starts describing how she actually would be interested in applying for a couple of jobs this year. This is happening in the order of seconds by stimulation of the vagus. What is the machine? What is it actually how does it connect her? That one is an implanted electrical stimulation device that's placed probably on there are many branches of the Vegas and so on a branch that isn't gonna impact breathing. Sometimes people have challenges with swallowing. So there are problems with doing that Carl, a big part of his mission, is to create very small light diodes that can stimulate nerves without the need to inject viruses and things of that sort. So that while I think at the time not too far from now, Thanks to his work and the work of other bioengineers, we are going to be able to stimulate for instance just the serotonin neurons in the rafae that lead to active coping. This is a well known phenomenon. Whereas when you take Prozac or Xoloft to one of these other drugs, it will stimulate those neurons, but will also stimulate serotonin receptors on the spinal neurons that control the sexual response, and that's why they have sexual side effects. So more precision is coming So as it relates to vagus, the other way in which the vagus is stimulating is something that we do quite often. We have neurons in our gut. That we all hear about the gut brain access and people say what's your second brain, but very seldom does anyone actually describe how the second brain actually impacts the other brain. And the simple way to put this is we have these neurons that live in the mucosal lining of our gut. And those neurons sense three things. They sense fatty acids, so they like fat. They sense amino acids. They love that umami flavor and they love amino acids because that's vital to protein repair metabolism, etcetera. Protein synthesis, excuse me, and they like sugar. And when you eat something that has fatty acids, amino acids, or sugar, These neurons send a signal. They're part of the vagus nerve up to a little cluster of neurons in your neck called the nodose ganglia, N0D0SE. And the no dose ganglia then stimulates your deep brain centers to release dopamine. And the amazing thing about this, these are data from a guy named Diego Boorhis at Duke University. The amazing thing about this system is that even if you numb the mouth, even if you just garbage a person or an animal and put these substances into the stomach, you will seek more of these foods. And so you're actually seeking sugar, amino acids, and fat. More when you ingest those foods independent of how they taste. And so this has a whole set of implications for hidden sugars and the fact that so many of the foods we eat, we just find ourselves eating more of them. We think this doesn't even taste don't even know why I'm eating this. It's because these neurons in your gut are stimulating dopamine release. And as we talked about before, dopamine isn't a molecule of pleasure. It's a molecule of making you want to do whatever led to dopamine release. Yeah. The molecule of more, the molecule of more. So the vagus is multi faceted, and we will soon hopefully subdivide it into some more meaningful pathways. I don't like to knock on anyone else's work, but I do think that most of what you read out there about the Vegas and what it does and various theories about it are partial truths to total nonsense, but they are partial truths total nonsense that were grounded in the biology as we understood it at the time, and just a lot more has been understood in the last ten years or so. So no disrespect to those people, but it's time for a revision. Maybe two or three more questions, then we'll we'll go. Get some food. Something along those lines. The first is, what books have you gifted the most to other people? Or are there any books that come to mind that you've gifted often to other people? I love poetry and It's almost cliche now to say this because so many people like his work. But I think David White's work is just beautiful and is is a wonderful kind of entry point to to poetry. I'm also a big Wendell Berry fan. He's written a lot about farming and the natural world, and I've never met him, but I'm a huge Wendell Berry fan. So I'll sometimes give Wendell Berry books as gifts. The book that I I think is perhaps at least to me the most beautiful book of all is Longitude. By Davosople about the history of the discovery of timekeeping at Ocean, which is not a trivial problem to solve. And it's just a beautiful story of how scientists, or in this case, a particular scientist merge the quest for a technology with a scientific problem with adventure. And going out on boats and, you know, risking one's life for the sake of science is something that resonates with me a bit. It's a beautiful short book and it's very accessible to anybody whether or not you have a background in science or not. And she's an absolutely wonderful writer, and so that's the one I gift most often. Is there a particular David White book or starting point that you might there a particular David White's book or starting point that you might recommend? You know, I own several of his books, but I confess that I I'm forgetting the titles now, you know, what's interesting about David White is that his poetry is best consumed by listening to him read it because he does this thing of repeating things You know, I own several of his books, but I confess that I I for getting the titles now. You know what's interesting about David White is that his poetry is best consumed by listening to him read it. Because he does this thing of repeating things twice, and his cadence is so impressive. And so I would even though I I load to kind of push people toward online do buy his books. But I would suggest just going online and listening to a YouTube video or watching a YouTube video of David reading one of his poems. He's onto something. The thing about The thing about poetry that's so fascinating to me is the same reason why I love anything sung by Bob Dillon or Joe Strommer, is that the words don't necessarily make sense in the pure cognitive landscape. They're tapping into some sort of deeper layer of the nervous system that defies the normal structure of sentences and They're tapping into some sort of deeper layer of the nervous system that defies the normal structure of sentences and thoughts. And so I think they good poets are accessing the subconscious. And it has nothing to do with rhyming. It has to do with accessing some layer of neurobiology that we just don't have a name for. Andrew, this question is sometimes a complete dead end, and I'll take the blame for that if it is. But just to just to go fishing and see what we catch here. If you could put anything on a gigantic billboard metaphorically speaking, to get a message out, quote, an image a word could be anything, a quote from someone else. Anything at all to billions of people? What might you put on that billboard? Well, assuming this is a big billboard, I could probably squeeze two things on there, but I would diminish the impact of either one. So it's so simple, but it's the most use at least it's been the most useful thing in life to me, which is credit goes to the oracle, which is know thyself. If there's one thing that's a really useful pursuit is to Take a really good stock of what you've come into the world with and where you happen to be at present. Get really honest about that with yourself, And in doing that, it illuminates the path to filling in the gaps and improving oneself. And knowing myself is a dynamic process. And the answers to knowing nice, how often what that is will change over time. But that is the question that I think everybody as soon as we are able to should be asking ourselves and constantly updating. Know thyself, what was second pick? You can put it on the other side of the bellboard. Yeah. The other one was far weaker as the one, I think, but use the body to control the mind. I really worry about this current state of the world where people are so unable to regulate their autonomic nervous system. They're stressed, they're angry, they're pissed. And look, I suffer from this too. Someone's sometimes I comment on whatever. I'm mostly on Instagram, but sometimes on mostly on Instagram, but sometimes on Twitter and I notice all this anger and stuff and you start getting pulled into it from time to time. I regulate my behavior. I don't respond, but we're all subject to this, but almost all harm, almost all self harm. And unfortunate things in life are the consequence of a poorly regulated autonomic nervous system. We say the wrong thing. We we do the wrong thing. We're impulsive. Etcetera. And I think controlling the autonomic nervous system is simple in one sense. And challenging in the other, simple in the sense that the tools exist. I do believe that respiration and vision are the two ways to control the autonomic nervous system in real time, the best ones. And at the same time, it's it's very hard to do. So we have to remind ourselves that's why I'd wanna put it on the billboard that when your mind isn't where you want it to be, use your body to control your mind. I love that. Gonna use that on a long hike with the pooch a little later today. And will also include, for everybody listening, show notes with links to various resources, all the resources that we've discussed, so the the various types of breath work. I'll also add a name which is Leah Lagos, Dr. Leah Lagos' has done a lot of really good work looking at resonance training, using breath work for improving Leah Lagos, has done a lot of really good work looking at resonance training using breath work for improving HRV. Although improved HRV is really just to proxy for all of these other desirable outputs and effects in the world and and in life. So we'll include all of that in the show notes Andrew, we've covered a lot of ground. Is there anything else that you would like to mention or say or point people to and you requested the audience, anything at all that you'd like to add before we wrap up for today? We mentioned some of the things at the beginning. You know, I teach neuroscience on Instagram at Huberman Lab. Those are resources, brief snippets anywhere from one to three minutes about neuroscience exciting papers. I see a lot of tools. Be wonderful if people wanna check out the podcast. And we cover a lot of topics, not just neuroscience. And we batch those by month so that we do four or five episodes in one thing like hormones, and then move on to something and we batch those by month so that we do four or five episodes and one thing like hormones and then move on to something else. And I suppose one request would be we have the saying in a laboratory. It's certainly not unique to laboratories, which is watch one, do one, teach one. And what would be most gratifying for me would be if people find tools that they find useful and they that they learn about them, that's the watch one part that they do them. They apply them in their own life and modify them if you like. And then I think the way the world works best at least in my view is when people go on to teach those tools and Attribution isn't required. I didn't as I always say, you know, I wasn't consulted at the design phase, and I don't know anyone else that was either. So, you know, mother nature and deserves Neurobiology deserve credit for all this. And so if people would like to learn, practice, and teach, I like to think that the world can improve by virtue of sharing of tools. I love it. I dig it, man. And there are number of places people can follow you and should check you out as you mentioned, the Humminlab podcast, humanlab dot com, and Humminlab at humanlab on Instagram and Twitter. This has been so fun. And I really appreciate all the time. It's been real pleasure spending time with you, Andrew. And I look forward to many more conversations. I'm feeling that people will want a round two. So until then, thanks to you and thanks to everyone for tuning in. Hey, guys. This is Tim again. Just a few more things before you take off. Number one, this is five bullet Friday. Do you want to get a short email from me? And would you enjoy getting a short email from me every Friday if that provides a little morsel of fun before the weekend. And Five Below Friday is very short email where I share the coolest things I've found or that I've been pondering over the week that could include favorite new albums that I've discovered. It could include Gizmos and gadgets and all sorts of weird shit that I've somehow dug up in the the world of the esoteric as I do. It could include favorite articles that I've read and that I've shared with my close friends for instance. And it's very short. It's just a little tiny bite of goodness before you head off for the weekend. So if you want to receive that, check it out. Just go to four hour workweek dot com. That's four hour workweek dot com. I'll spell that out and just drop in with your email and you will get the very next one. And if you sign up, I hope you enjoy it. This episode is brought to you by gun. I have to their guns and they're worth their weight in gold and using them every single day, whether you're an elite athlete or just a regular person trying to get through your day, muscle pain and muscle tension are real I have two TheraGones and they're worth their weight in gold. I've been using them every single day. 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And the gen four air guns start at just the Gen four Thera guns start at just one hundred and ninety nine dollars. I said I have two. I have the I have the climb, and I also have the Pro, which is a super cat like version. My girlfriend loves the soft attachments on My girlfriend loves the soft attachments on that. So check it out, go to So check it out. Go to theragon dot com slash Tim one more time. Theirgun dot com slash tip. This podcast episode is brought to you by helix podcast episode is brought to you by Helix sleep. Sleep is super important to me in the last few Sleep is super important to me in the last few years. I've come to conclude it as the end all be all that all good things, good mood, good performance, I've come to conclude. It is the end all beyond that all good things good mood, good performance, good everything seemed to stem from good sleep. So I've tried a lot to optimize So I've tried a lot to optimize it. it. I've tried pills and potions, all sorts of different mattresses, you I've tried pills and potions, all sorts of different mattresses, you name it. And for last few years, I've been sleeping on a Helix midnight luxe mattress. I also have one in the guest bedroom and feedback from friends has always been fantastic. It's something that they comment It's something that they comment on. Helix sleep has a quiz takes about two minutes to complete that matches your body type and sleep preferences to the perfect mattress for you with Sleep has a quiz, takes about two minutes to complete that matches your body type and sleep preferences to the perfect mattress for you. With helix. There's a specific mattress for each and every body that is your there's a specific mattress for each and every body. That is your body. Also your also your taste. So let's say you sleep on your side and like a super soft bed, no So let's say you sleep on your side and like a super off bed. No problem. Or if you're a back sleeper who likes a mattress that's this firm is a Or if you're a back sleeper who likes a mattress that's as firm as rock. We've got a mattress for you got a mattress for too. Helix was selected as the number one best overall mattress pick of 2020 by GQ magazine, wired, apartment therapy, and many others just go to helix, sleep.com/tim, take their two minutes sleep quiz, and they'll match you to a customized mattress that will give you the best sleep of your Helix was selected as the number one best overall mattress pick of twenty twenty by GQ magazine, Wired, Apartment Therapy, and many others. Just go to helix sleep dot com slash Tim, take their two minute sleep quiz, and they'll match you to a customized mattress that will give you the best sleep of your life. They have a ten year warranty and you get to try it out for one hundred nights. Risk-free even pick it up from you if you don't love risk free. They even pick it up from you if you don't love it. And now my dear listeners helix is offering up to $200 off of all mattress orders and two free [email protected] slash And now my dear listeners, Helix is offering up to two hundred dollars off of all mattress orders and two free pillows at helix sleep dot com slash Tim. These are not cheap pillows These are not cheap pillows either. So getting to for free is an upgraded so getting two for free is an upgraded deal. So that's up to $200 off and two free [email protected] slash Tim that's helix, H E L I X sleep.com/tim for up to $200 So that's up to two hundred dollars off and two free pillows at helix sleep dot com. Slash, Tim. That's helix HELIX sleep dot com slash tim for up to two hundred dollars off. So check it out one more So check it out one more time. Helix, H E L I X Helix HELIX sleep dot com slash him.