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that's w-e-l-l-n-e-s-s-e.com. Hello

3:39

and welcome to the Wellness Mama podcast.

3:41

I'm Katie from wellnessmama.com and this

3:43

episode is all about peptides and

3:45

understanding them and how to use

3:48

them optimally and I'm here

3:50

with Natalie Nidum who is a podcast

3:52

host and longevity biohacker, a holistic

3:54

nutritionist of human potential and epigenetic coach.

3:57

She's a self-proclaimed science geek with a

3:59

passion. for human health. And a

4:01

few years ago, she did a deep

4:04

dive into peptides as a health optimization

4:06

option. And she was captivated by the potential

4:08

of these tiny proteins, and thus

4:11

became the catalyst for the launch of her

4:13

growing Facebook community, the Optimizing Superhuman Performance

4:15

Group, and to feed a

4:17

growing interest in these incredible compounds. And

4:19

a year later, she launched the Biohacking

4:21

Superhuman Performance Podcast, which is now rated

4:23

in the top 50 in her category.

4:26

Her passion is looking at longevity through the

4:28

lens of all we can do in every

4:30

area of our lives to promote vibrant health,

4:32

boundless energy, and more. She works

4:34

with clients one-on-one and manages these communities.

4:37

And we go deep on the topic of

4:39

peptides today. So let's join that. Natalie,

4:42

welcome. Thank you so much for being here. Thank

4:45

you so much for having me, Katie. It's

4:47

an honor to be here. I've heard about

4:49

you for a couple of years, actually, well,

4:51

longer than a couple of years. Your

4:53

reputation precedes you, but personally, there was a

4:55

woman that came to my retreat that I

4:57

ran in the Dominican Republic a couple of years

5:00

ago. And she kept telling me, oh, my friend,

5:02

Katie, wellness momma, you need to meet her,

5:04

need to meet her. And then finally, we

5:06

met last November in person. So

5:09

it's really nice to reconnect. Yes.

5:11

Well, I'm so excited to learn from you today. And

5:13

we're going to get to go deep on the topic

5:15

of peptides, which is a topic I'm excited to learn

5:17

about on a personal level. Before we

5:20

jump into that, though, totally unrelated, I did

5:22

not know until researching for this episode that

5:24

your first language is French. I would never

5:26

have guessed that. But that's true. Your first

5:28

language is actually French. It is.

5:30

I didn't actually speak a word of English

5:32

until I went to school. Wow.

5:35

Well, that is incredible. And I didn't speak a word of

5:37

English when I first went to school. So apparently, I didn't

5:39

say much for a couple of months until

5:42

I figured it all out. And

5:44

then it was like, all right, we got this. Well,

5:47

my mom speaks French. I unfortunately didn't pick up any of

5:49

that, or I would try to say something in French to

5:51

you. But that's really cool. And then a

5:53

topic that you are also extremely well versed in and

5:55

I'm most excited to learn from you about is the

5:57

topic of peptides because I would guess most people... have

6:00

heard of peptides by this point, but

6:02

they probably still seem a little mysterious or

6:05

a little bit kind of high-barrered entry of understanding

6:07

how to even use them, and they're just not

6:09

typically a normal supplement you can just add to

6:11

your supplement regime. So to start off

6:14

really broad, can you explain kind of the broad

6:16

concepts of what peptides are and then we'll get

6:18

to dive into how they can be used? 100

6:21

percent. So peptides are the word

6:24

peptide means protein. So

6:27

a peptide is a chain and proteins

6:29

are made up of amino acids, which

6:31

are the building blocks of protein. And

6:33

so a peptide by definition is a

6:36

chain of amino acids that is 50

6:38

amino acids or fewer in length. A

6:41

polypeptide would be, I believe it's between 50

6:44

and 100 amino acids, and then anything above

6:46

that is just a protein. And

6:49

so proteins, as people may know, can

6:51

be hundreds of amino acids long and

6:53

they're very intricately folded.

6:55

Peptides, because they're a lot smaller,

6:57

can also be folded. But

6:59

basically, they're just tiny little proteins in

7:01

the body that act as signaling molecules.

7:04

They generally, they've been isolated from

7:07

our body. So they're naturally

7:09

occurring in the human body, but what's

7:11

happened over the last few decades is

7:13

people have kind of isolated them and

7:16

then use them in different ways

7:18

to kind of trigger desired responses

7:21

in the body by reapplying them. Yeah,

7:24

and that their capacity to be signaling is

7:27

what's most fascinating to me because I think

7:29

when we understand them broadly as essentially like

7:31

amino acids and the building blocks of proteins,

7:34

they seem like, okay, that seems like something that obviously

7:36

would be already in our body that

7:38

we can produce or we get from food. But

7:40

then when they're isolated like this, that's when they

7:43

sort of have their elevated potential,

7:45

I guess I would say. And I

7:47

know that within the world of peptides, there are so,

7:49

so, so many. How do these

7:51

signaling mechanisms work within the body? So this would

7:53

be different, for instance, than if we were just

7:55

getting some of the same peptides from a food

7:57

source when we're getting them in this like

7:59

isolated. for her? Yeah, so

8:02

I mean, so the exact same peptides

8:04

don't necessarily come from a food source.

8:07

I mean, I guess maybe

8:10

you might get some from

8:12

certain animal products and we'll

8:14

talk later or we'll

8:16

follow up with and talk about

8:18

bioregulator peptides separately because those are

8:20

definitely available in food. But

8:22

the peptides that we're talking about and you know,

8:25

just to bring it to a

8:27

place where people can get real clarity

8:29

on this, there's a very well-known peptide

8:32

that almost everybody's heard of and that's

8:34

insulin. And so insulin

8:37

is a peptide and it is

8:39

a signaling molecule in the body.

8:41

And so we make insulin from

8:43

our pancreas under normal circumstances. And

8:45

sometimes in certain disease states, people's,

8:48

you know, either the beta-hydralysis cells

8:50

get damaged or whatever happens and

8:52

we stop making insulin and stop

8:54

losing, we lose our ability to

8:57

properly process glucose. And so,

8:59

you know, the big discovery

9:01

was isolating insulin and then re-synthesizing

9:04

it in a lab and

9:06

then learning that by reapplying it to the

9:08

body, we can kind of supplement the

9:10

body's supply of and get it

9:12

to do what it would normally do if you had

9:14

insulin, if you were making it yourself. And

9:17

I would guess a lot of people don't even

9:19

realize that insulin is a peptide. Are there other

9:21

ones within the body that perhaps people have heard

9:23

of and may not realize are actually classified as

9:25

peptides? Well, you know, oxytocin,

9:27

for example, people think, you know, people have

9:30

heard, a lot of people have heard of

9:32

oxytocin. It's the, you know, it's the love

9:34

hormone and or it can be administered to

9:36

women in labor to kind of move things

9:39

along. And so oxytocin is

9:41

another peptide that is naturally made

9:43

by our bodies and

9:45

that can be, you know, synthesized

9:47

in a lab and then re-administered.

9:49

So all of these peptides that

9:51

people are talking about

9:53

really are either are very

9:56

often they're fragments of naturally

9:58

occurring peptides in the body. And

10:00

so we can, so

10:02

something like, for example, one of the ones

10:04

that possibly people have heard of. So now

10:07

I'm talking to the part of your audience

10:09

that's kind of been running ahead here, and

10:11

maybe they're a little bit further ahead. And so

10:13

one of the ones they may have heard of

10:15

is something called BPC 157. And

10:19

so what we'll notice is that in these

10:21

peptides that people are quite excited about that

10:23

have made quite a splash over the last

10:26

number of years, the names

10:28

of these peptides leaves a lot to be desired.

10:30

It's very often like a series

10:32

of letters and numbers. And that's

10:34

because they were named by scientists

10:37

who discovered them and isolated them.

10:39

So BPC stands for body protective

10:41

compound. And 157 actually is number

10:44

one to 57 because

10:47

it's that first to the, it's

10:50

where I think it's

10:53

going to be 157, but actually it's only 19

10:55

amino acids long. But

10:57

it has some designation of where

10:59

in the whole BPC

11:02

157 that's naturally occurring in our

11:05

guts. It has some indication about

11:07

that fragment, where they isolated the

11:09

fragment from. It

11:11

can't be one to 57 because then it would be

11:13

57 amino acids long. That's

11:15

so fascinating. And probably that one is the

11:17

most that has gotten the most mainstream attention.

11:20

So I'd love to go a little deeper

11:22

on BPC specifically because I know for my

11:24

basic understanding that can be taken orally or

11:26

it can be injected as many peptides are.

11:29

And it seems like perhaps it does different things when

11:31

in the different ways that it can be kind of

11:33

put into the body. But can you elaborate on what

11:35

BPC does and maybe some of the use cases that

11:37

you find for it? So,

11:40

you know, not only can it be used,

11:44

it can be used orally and

11:46

by subcutaneous injection, it can also

11:48

be used topically, it can be

11:50

used intranasally, it can be compounded

11:52

as eye drops. So it's a very,

11:55

very versatile peptide. And so I will

11:57

often refer to it as the Swiss

11:59

Army 9-1-1. of peptides because

12:01

it has an impact

12:03

on so many different tissues and

12:05

systems in the body. But it's

12:07

major superpower and the two

12:10

things that people really identify with

12:12

BPC-157 is healing

12:14

the GI tract, healing the gut lining,

12:17

and also healing musculoskeletal

12:20

injuries. So BPC-157 is the champion

12:22

of stimulating healing various tissues in the body. And

12:29

it does this primarily by acting as

12:32

a signaling molecule so it will attach

12:34

to certain ripsceptors on the outside of

12:36

the cells and initiate cascades. And

12:40

also by doing so sometimes it

12:42

even influences the expression of certain

12:45

genes that influence repair. But

12:47

it is also, can be

12:50

very useful for things like wound

12:52

healing, like actual wounds, surgical

12:54

wounds. It can be really

12:57

good for healing of burns. It

12:59

also is very powerful for

13:02

certain neurological issues. It

13:05

can help with remyelination of nerves. It

13:08

is also an anti-inflammatory. It can help with

13:10

pain. It can help in

13:12

animal studies. It was shown to be protective

13:14

from TBIs. You know, like if

13:17

I think about it long enough, I could come up with

13:19

another laundry list of things that it does. But you

13:21

get the idea. The idea is that this

13:24

little tiny protein is

13:27

a very versatile protein in the environment of

13:29

our system. The other thing that it does,

13:31

and the reason why it is

13:33

also so helpful for healing of injuries, is

13:36

that it upregulates the production

13:39

of the expression

13:41

of growth hormone receptors. And

13:44

so very often, BPC157

13:47

has been used in conjunction

13:49

with another category of

13:52

peptides called growth hormone secretagogues.

13:55

And those peptides basically stimulate

13:57

the brain to produce and

13:59

release your own growth hormone.

14:01

So you can imagine that now you've got

14:03

your BPC157 that's

14:05

initiating its own repair cascades, but

14:07

it's also pushing out these

14:10

catcher's mips for growth hormone and at the

14:12

same time you've got these growth hormones to

14:14

create a guys that are increasing your production

14:16

of growth hormone which is going to accelerate

14:18

healing as well. And

14:20

this is the one certainly that I have

14:22

the most personal experience with both on myself

14:24

with injuries and also my older kids that

14:26

are athletes. We've in our house recently had

14:28

a torn quad and a torn

14:30

meniscus and a sprained ankle and I will

14:32

say it's been amazing how rapidly it seems

14:35

to speed up that healing cascade and I

14:37

think anytime we're talking about peptides that's an

14:39

important point to highlight is because of the

14:41

way they work they're actually enhancing what the

14:43

body already knows how to do. This is

14:45

not like going around the body's natural mechanisms

14:47

it's enhancing the body's own healing capabilities versus

14:49

something like a pharmaceutical that might bypass something

14:52

that's going on within the body and

14:54

so these are like sort of like upregulating the

14:56

things your body already knows how to do

14:58

just like anytime we're talking about detox I always

15:01

like for my people we're actually just enhancing

15:03

the body's ability to detox we're not doing anything

15:05

externally that's causing this the body knows what to

15:07

do inherently and I know peptides extend far

15:09

beyond just VPC even though that's

15:11

the most well-known what are some of the other

15:13

ones that you commonly find people benefit from? So

15:16

you know one thing we should say about peptides

15:18

is they have they are in

15:20

a little bit of a gray zone right

15:22

now from a regulatory perspective the FDA has

15:26

taken note of peptides and has

15:28

reclassified them as class 2 compounds

15:30

which means that technically we're

15:32

not supposed to be using them anymore

15:35

so I just want to put that out

15:37

there that's not obviously that

15:39

doesn't stop a lot of people who

15:42

take matters into their own hands and bio

15:44

hackers and and such and you know and

15:46

so forth but the FDA

15:48

has decreed that they don't feel

15:50

that there's enough research

15:53

and information around them for them to just

15:55

be available to them to the market so

15:57

having said that in terms of

15:59

what I seen over the last number of years.

16:02

You know, it's hard to pick. It's a little

16:04

bit like saying, well, who's your favorite child? And

16:06

you're like, well, I don't have a favorite that

16:08

just depends, right? I mean, they're all my favorite.

16:11

But another one that I think is very

16:13

interesting and notable is thymus

16:15

and alpha one, which is a

16:18

thymus peptide. So your thymus gland

16:20

lives in your chest right behind

16:22

your breastbone. It is in

16:24

many ways the seat of your immunity

16:26

and our thymus gland will start to

16:28

kind of involute as we get older.

16:31

But it produces all

16:33

of these compounds that

16:36

trigger the immune system to do

16:38

certain things. And so thymus and

16:40

alpha one is

16:42

a peptide that supports

16:45

the innate immune system. So

16:47

it can be very

16:49

useful for people with

16:52

certain types of autoimmune disease. So as

16:54

long as they are not th two

16:56

dominant, then thymus and

16:58

alpha one is a great choice for them,

17:00

because it's going to bring up th one

17:02

side of the immune system, which is the

17:04

innate immune system. It's also been shown to

17:06

be very effective when trying

17:09

to deal with sickness,

17:11

like somebody's coming down with the flu, thymus

17:13

and alpha one can really help to speed

17:16

up that recovery, all kinds of

17:18

viruses as a matter of fact. And so it's

17:22

a very powerful compound. It does have

17:24

orphan drug status in the US, but

17:26

it's only approved for hepatitis B and

17:28

C right now. But

17:31

it's a really interesting peptide. Another

17:33

one that it could one day kind

17:36

of push BPC-157 off the official

17:41

Swiss Army Knife seat.

17:44

And that's a that's a peptide

17:46

called GHK. It's

17:49

called GHK. But the symbol for it

17:51

is GHK-CU. Now the CU

17:53

stands for copper. And

17:56

so very often people will refer to it

17:58

as the copper peptide. And

18:01

so what's really interesting about

18:03

GHK is that it is

18:05

particularly beneficial for skin. And

18:08

that's where it kind of got its claim

18:10

to fame. The doctor who discovered it and

18:12

brought it to market is a doctor by

18:15

the name of Dr. Lauren Pickart, who's an

18:17

American doctor, and I believe it was in

18:19

the 1970s, early 1970s is when he discovered

18:21

GHK copper. What's amazing

18:23

about this peptide is it's

18:26

only three amino acids long. So

18:28

it's the tiniest, the tiny peptides.

18:30

And what it can do, because it's so tiny,

18:32

is it can

18:34

actually influence the

18:37

expression of DNA. So it actually

18:39

influences your gene expression. And it's

18:41

been studied and shown to reset

18:44

many, many genes, like thousands of genes back

18:47

to their useful setting. It

18:49

can also be very helpful for

18:51

healing. As it turns out, it's

18:53

also really great at healing wounds,

18:56

and particularly at reducing scarring. And

18:59

it's incredibly powerful for healing wounds.

19:04

But interestingly enough, it also is now

19:06

being shown to have some benefits for

19:09

even anxiety for some people. It

19:13

acts on every tissue that needs to

19:15

heal, including the gut. So

19:17

it may actually work really well

19:19

hand in hand with BPC157, because

19:22

they would kind of operate on different planes,

19:24

but with the same, with a common goal.

19:27

So it's kind of like going out the

19:29

same problem through a couple

19:31

of different pathways. And then

19:33

the other thing that BPC, that GHK does

19:35

is it helps with collagen

19:37

and elastin in the body. So it

19:40

helps. So this is why you

19:42

will find a number of topical,

19:45

like kind of, I

19:47

don't like the word anti-aging particularly,

19:50

but you will find a number

19:52

of skincare brands that use GHK

19:54

copper either in small proportion or

19:57

as the main ingredient in their

19:59

product. So is

20:01

GHK used topically primarily or is

20:03

it also used internally? So

20:06

it kind of depends what you're doing with it. So it

20:08

can be used topically 100%. It

20:11

can also be used by

20:13

subcutaneous injection. Because

20:15

it's so tiny, there are people who

20:17

feel that it can also be taken

20:19

orally. I haven't seen a lot of

20:21

data on that, but there's definitely

20:23

a couple of supplement companies out there that offer

20:25

it. And I think it

20:27

can also be used intranasally. So

20:29

the intranasal administration is always really

20:31

interesting, right? Because we don't think

20:33

of our nose as a point

20:35

of entry necessarily, other than maybe

20:37

to the sinuses. But this is

20:39

where it's going across the intranasal

20:42

membrane and being absorbed straight into

20:44

the bloodstream. And to

20:46

some degree, even might have an

20:48

impact on the brain through that route as well. And

20:51

so one of the communities of

20:53

people that I've seen using GHKCopper

20:56

and even BPC157, both

20:58

of them are people who have a

21:00

genetic condition called Ehlers-Danlos syndrome. I don't

21:03

know if you've ever heard of it, EDS. And

21:06

so these are people who very often

21:08

are hypermobile. They don't make collagen properly.

21:11

And they can have issues all over

21:13

the spectrum. They can show up as

21:15

just being super flexible. But in some

21:18

cases, they suffer from POTS, where

21:20

their body is not able to regulate their

21:22

blood pressure properly. These are

21:24

people who can lift

21:26

up their hand and dislocate an elbow or a

21:28

wrist. It can get very

21:31

extreme. And those populations of

21:33

people have found that both GHK and

21:35

BPC157 seems to have enough of

21:38

an impact on their

21:41

tissues that it helps them to be a

21:43

little bit stronger. The only thing is that

21:45

because their condition is genetic, you kind of

21:47

have to keep using the peptides to keep

21:49

getting the benefits because they're not going to

21:51

fix your genes. They're just going to maybe

21:53

influence the way they express. That

21:56

makes sense. My first experience with that one has

21:58

been recently, actually. off on

22:00

a diagonal, the top part of my finger.

22:02

And I was wondering if it would

22:04

actually regenerate or if I would have kind of like a pointy

22:06

finger. And it actually, I think between that

22:09

and I was already in a pretty advanced

22:11

growth hormone state from fasting. It has fully

22:13

regenerated in less than two weeks. So I

22:15

don't know that that's entirely from the GHK,

22:17

but it certainly didn't hurt to have that

22:19

on board as well. This

22:23

episode is brought to you by Beam

22:25

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22:28

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22:30

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22:32

and from what I'm seeing in the research

22:34

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22:36

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22:38

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22:58

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23:01

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with it he on the end and

24:11

this is a company that I got

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to help profound and formulate the product

24:15

for and one that I care deeply

24:17

about. Oral health has been a research

24:19

a fine research topic for me for

24:21

well over a decade. When I discovered

24:23

I had some cavities and started learning

24:25

about the process of riemann realization and

24:28

how are Keith has the ability to

24:30

stay stronger and healthier dependent on a

24:32

lot of factors including or nutrition and

24:34

including or oral microbiome. And the environment

24:36

of our mouth. And that's what I

24:38

really focused on when formulating this product.

24:40

And this is why we use something

24:43

called hydroxy Appetites which is a naturally

24:45

occurring mineral that is used in the

24:47

in the and will have our teeth

24:49

and there's a business meeting. Studies that

24:51

show that this is really effective at

24:53

helping keep keep strong and healthy and

24:55

this is also why I have any

24:57

formulation shows not use fluoride because it

24:59

had many of the same upsides without

25:01

some of the potential downsides and is

25:03

certainly much safer for children as. Well

25:05

but as I said I also really

25:07

delved into the research around the oral

25:09

microbiome and I love that this is

25:12

now in emerging area of conversation and

25:14

research that what are my aura microbiome

25:16

a strong that helps us avoid both

25:18

ends of the stuff one would be

25:20

is didn't like struck me ones which

25:22

is the bacteria linked to cavities as

25:24

well as the host of bacteria that

25:26

early a things like to divide us

25:28

both of those can be com added

25:30

by having a really healthy oral microbiome

25:32

we've recently also releasing like probiotic meant

25:34

that have for problematic strains. That

25:36

help enhance the or a microbial. And

25:38

by choosing microbiome safe ingredients as well

25:40

as address the appetite for tooth enamel

25:42

in the toothpaste, you can check out

25:45

those as well. There are full line

25:47

of hair care products and other oral

25:49

health products as well. My going to

25:51

wellness.com that W E L L L.

25:53

E S S. eat.com. I.

25:57

think also when it comes to the peptide

25:59

conversation it gets mystifying for a lot

26:01

of people is you mentioned like subcutaneous

26:03

injection. I think there's of course

26:05

the category of anything involving needles can feel very

26:08

scary to a lot of people, but also there's

26:10

a lot of seemingly difficult math involved when you're

26:12

talking about reconstituting and dosing and there's so much

26:14

that goes into that. Any tips

26:16

on demystifying that process a little bit because this might

26:18

be a totally new area for a lot of people?

26:21

Yeah. So the subcutaneous injection, to be

26:23

honest, is a barrier of entry for

26:25

most people. And a lot of people,

26:28

you don't need too many people

26:30

who just love poking themselves with needles. Like

26:32

it's just not a thing. I

26:34

personally thought of myself as needle phobic until

26:36

I kind of got into this space. But

26:39

what we're talking about here is essentially like

26:41

an, it is an insulin needle. So it's

26:44

a tiny little needle. It

26:46

is administered in the

26:48

layer of fat right underneath the skin.

26:50

So that's where we're saying subcutaneous. And

26:53

I think that for people who decide to

26:56

kind of move into this space, you do

26:59

have to educate yourself. You have to be, to

27:02

me, you have to be fastidious

27:04

about cleanliness. We're talking

27:06

about alcohol, sweat, like everything that you see

27:08

your doctor or a nurse doing before they

27:10

give you a shot, you have to be

27:12

prepared to kind of take that on. You

27:14

want to make sure that the area is

27:16

super clean, that you've wiped it with alcohol.

27:18

You're never going to reuse needles. People ask

27:20

me that all the time. You

27:23

want to swab the top of the vial before

27:25

you put the needle in. So the

27:27

way that people reconstitute these peptides, particularly if

27:29

they're not getting them from a compounding pharmacy,

27:32

is they will very often, they will arrive

27:34

in a tiny little vial

27:36

that half the time is going to

27:38

look almost empty. And that's

27:40

because we're talking about very small amounts

27:42

of product. And unless the

27:45

manufacturer you're getting, the lab you're getting

27:47

it from is using

27:49

fillers like Manitol. If

27:52

it's just the peptide, sometimes it looks like there's

27:54

a couple of grains and stuff in there and

27:56

nothing else. So That takes a

27:58

little bit of getting used to. Why? Don't

28:00

men happen if people would have to

28:02

reconstitute their peptides and what that means

28:05

is you're basically mixing it with a

28:07

liquid. To turn it into a

28:09

solution right? and if if is being

28:11

used for such a tedious. Injections.

28:14

It's the that solutions. This solution

28:16

that's most commonly used is called

28:18

bacterial static water. And what bacteria

28:20

static water is is water with

28:22

a very low concentration of alcohol

28:24

and it's and just enough. I'll

28:27

call that it stops the growth

28:29

of bacteria. Now. What's important

28:31

in and Sincere is it doesn't

28:33

stop. It doesn't kill bacteria so

28:35

that's why I have to be

28:37

so careful when you're mixing things

28:39

up or whenever you're introducing a

28:41

needle into the violence because if

28:43

you if you introduce bacteria it's

28:45

it will stay. A won't grow,

28:47

but it will stay so. In.

28:50

Terms of doing the mass you mentioned

28:52

bass and the mass is really baffling

28:54

to people. I'm not gonna lie, was

28:56

pretty darn baffling to me at the

28:59

beginning. I think that you know this

29:01

is where getting help from a code

29:03

sure someone who knows what they're doing

29:05

to to teach you the math is

29:07

a really great idea or you can

29:10

use there are some online peptide calculators.

29:12

The trick there is you need to

29:14

know what dose. Your auster paid

29:16

so. You can't You can't not

29:18

know the dose And what I'll

29:20

say is that what you need

29:23

to get it down to is

29:25

how many milligrams of peptide are

29:27

there in the vial per milliliter

29:29

And that gives you your concentration.

29:31

In. Once you have an idea of

29:33

that now we've answered going through math

29:36

to understand how much of this solution

29:38

do I need to draw out to

29:40

get my desire? Does. Does

29:42

that what you're after? That. Help. exactly

29:45

yes he i feel like that's a big hurdle

29:47

for a lot of people and use had some

29:49

the up to eight stuff and i know that

29:51

like any time a session we're talking about injecting

29:53

anything safety of course that concerns are there any

29:55

things to know on the c t side or

29:57

risks that the it's people might need be aware

30:00

of before they would consider even researching and going

30:02

down the peptide road? Yeah.

30:04

So, I mean, look, peptides are, on

30:06

the one hand, there are people who've

30:08

been using peptides

30:10

for a couple of decades, at least. But

30:13

for the most part, let's just say it's the

30:16

last 10 to 15 year phenomenon, and

30:18

it's really bubbled up into the mainstream

30:20

in the last five years.

30:23

And so, while there

30:25

is some research

30:28

out there around peptides, there's not a whole

30:30

lot of human research, and there's certainly not

30:32

a whole lot of long term human studies.

30:35

So, there's always uncertainty.

30:38

I think that there's a couple of things. On the one

30:41

hand, what we've observed is that

30:43

they have a fairly good safety profile.

30:46

On the other hand, it is not

30:48

inconceivable, nor is it unheard of, that

30:50

people might have an allergic or histamine

30:52

response to certain peptides, and it depends

30:54

on the person. So, the

30:56

idea that, oh, nothing could possibly

30:58

go wrong actually is not

31:00

true. Secondly, it is

31:03

possible that people sometimes have adverse

31:05

reactions to certain peptides because of

31:08

pre-existing conditions that they already have.

31:11

So, for example, I would say that,

31:13

like with the growth hormone sub-treatagogues that

31:15

I mentioned earlier, very

31:18

often, not very often,

31:20

but it's not uncommon to

31:22

see people have a histamine response to those.

31:24

And what that looks like is

31:26

at the injection site, they will

31:28

get like a hot red

31:31

bump, almost like a mosquito bite.

31:33

If they continue, one of two

31:36

things happens. Either the

31:39

bump gets bigger, hotter, and more itchy, which

31:41

is a definite sign by the body to

31:43

back down and don't do that again because

31:45

that can escalate. Or sometimes, you

31:49

know, the immune system, it's almost like

31:51

it has an initial reaction and then it backs down.

31:54

But the other thing that can happen with

31:56

ghost hormone secretogues is it can cause a

31:58

slight increase in blood pressure. That

32:00

increase should be transient, but for some

32:03

people, it's not. So

32:05

you have to be very cognizant

32:07

of where you're at, what

32:09

your baselines are. BPC157 on

32:12

paper is supposed to

32:14

balance the dopaminergic, serotonergic, and GABAergic

32:17

systems in the brain, and

32:19

yet there are some people that get very

32:21

severe anxiety from BPC157. I

32:25

think the takeaway is that

32:28

there's a lot we don't know because

32:31

we know that the companies that really

32:33

have the money to spend on that

32:35

kind of research are big

32:37

pharma companies. Because

32:39

they can't patent the peptides as

32:41

they are, their motivation to

32:44

do that research is fairly low, and that

32:47

big research hasn't been done yet. I think

32:49

what's happening, and what some people believe might

32:51

be happening with this whole FDA thing, is

32:54

that just like with the

32:56

GLP1 agonist, so things like Munjaro and Ozimpic

32:58

that have made quite a splash over the

33:00

last couple of years, those are

33:03

peptides. What happened with those

33:05

is that the pharma companies did the research

33:08

and figured out a way to... It's

33:11

not just that they figured out a way. They

33:14

modified the molecules so that it would have

33:16

a much longer half-life in the body and therefore

33:19

deliver a certain outcome. In

33:22

doing that, they did something that they were able

33:24

to patent. With BPC157, I

33:26

think what we're going to see is

33:29

we're going to... At some point, we're going

33:31

to see some medication come out that is

33:33

based on or a derivative of BPC157.

33:38

I guess the answer to your question is people

33:41

need to know that peptides

33:43

are very powerful. On

33:46

the one hand, they seem to be fairly

33:48

safe because they come from our bodies, but

33:50

on the other hand, there are certain pathways

33:52

that might get activated that we're not familiar

33:54

with yet. In situations

33:57

where someone, for example, has active

33:59

cancer... or certain health

34:01

conditions, I think it's really important

34:04

to seek out a practitioner or

34:06

a physician who is familiar with

34:08

peptides and really how they work

34:10

at a cellular level so that

34:12

they can properly guide you and

34:14

avoid going the wrong way. With

34:16

Simosin Alpha-1, which many people

34:18

think is super safe and great for everybody,

34:20

I've seen people have really bad reactions because

34:23

they were already TH2 dominant and

34:25

it just pushed them over the edge. And

34:28

it sounds like we're in a time of sort

34:30

of to be continued on the conversation as everything

34:32

unravels with the FDA and as these things push

34:34

for approval in different avenues, but it's

34:36

like a fascinating topic and one that hopefully we

34:38

get to do more follow-up in the future as

34:40

those pieces start to unravel. For people who want

34:43

to keep learning more about peptides, I know you

34:45

have a lot of resources available online. Where can

34:47

people find you and keep learning from you? So

34:50

the best place to go is my website,

34:53

which is natnittem.com. And

34:55

on that website, there's a tab

34:57

at the top that says BSP

34:59

Community, like Bob, Susan, and Peter

35:02

Community. And that

35:04

community is a private membership community that I

35:06

run on Mighty Networks. And if

35:08

you join as an annual member, you

35:11

actually get access to my peptide crash

35:13

course, which I put together a

35:15

couple of years ago just really to help

35:17

people kind of get their footing in

35:21

this whole peptide space and really understand the

35:23

basics about some of the most common peptides.

35:26

And you can

35:28

also follow me on Instagram, which is just

35:30

my name, Natalie Nittem. And

35:32

then I've got a Facebook group that I

35:35

started about four years ago, I want to

35:37

say that I'm not in as much anymore,

35:39

but it's a really, it's

35:42

a, I'll call it a very vibrant

35:45

and active community. It's

35:47

gotten pretty big. It's around 22,000

35:49

members right now. And so it's

35:51

called Optimizing Superhuman Performance. And

35:54

mostly it's run by a couple of admins, but I'm

35:56

in there every once in a while as well. Awesome.

36:00

of those are linked in the show notes for

36:02

you guys listening on the go. And this has

36:04

been such a fun conversation and like I said,

36:06

this is a new area for me. I'm just

36:08

beginning experimentation with it. So, we can have follow-up

36:10

conversations in the future, but thank you so much

36:12

for your time and for everything you shared today.

36:14

Thank you, Katie. It's been a pleasure. Thank you so

36:17

much for having me. And thanks

36:19

to all of you for listening and I hope that

36:21

you will join me again on the next episode of

36:23

the Wellness Mama podcast. If

36:26

you're enjoying these interviews, would you please take two

36:28

minutes to leave a rating or review on iTunes

36:30

for me? Doing this helps more

36:32

people to find the podcast, which means even

36:34

more moms and families could benefit from the

36:36

information. I really appreciate your time and

36:39

thanks as always for listening.