Bryson is a beautiful, happy boy. But a mysterious illness means he can’t walk, talk, or feed himself. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motiva

An Update

Sep 7th, 2021 58m 52s

Bryson's family struggles with the trials of pandemic life. A death in the community underscores the need for a cure — and promising new research might make one possible.

Two Futures

May 25th, 2020 58m 52s

After months of waiting, the “Bryson mouse” is finally ready for lab tests that will provide new insights into treatments and cures. And Bryson’s parents explore two possible versions of Bryson’s future.For transcripts of this series, please

Pilgrimage to Boston

May 18th, 2020 40m 43s

Bryson’s parents travel to Boston/Cambridge, the global capital for rare disease research. Their goal: to ask private biotech companies to help in their search for a cure. Scientists provide new clues, but also raise difficult questions.For t

The Ethics of Cure

May 11th, 2020 49m 58s

Finding a cure for Bryson no longer seems impossible. And that raises new questions about the ethics of this journey. Bryson’s family seeks out new perspectives and learns why “cure” is a loaded term in the disability rights community.For tra

Making a Mouse

May 4th, 2020 43m

Scientists in Toronto get to work building a mouse with Bryson’s precise genetic variant. Plus, the family travels to Atlanta to provide blood samples for a researcher to create DNA-based “mini-brains” in his lab. Could this cutting edge scienc

A New Hope

Apr 27th, 2020 53m 4s

Bryson’s family travels to meet other GRIN1 patients, including Bryson’s GRIN-twin Olivia. And research on mice offers new hope for finding a cure. But a new illness means that the family now needs two medical miracles.For transcripts of this

The CRISPR Revolution

Apr 20th, 2020 33m 38s

Bryson’s parents explore CRISPR, a new technology with the potential to cure dozens of diseases once thought incurable. But gene editing comes with risks — not just for individual patients, but for the human race.For transcripts of this serie

Getting a Diagnosis

Apr 13th, 2020 45m 2s

From violent seizure-like episodes to insensitive comments from strangers, Bryson has a hard life. But after years of searching, doctors finally provide a diagnosis. The news changes everything for Bryson’s parents and provides a possible path

The Mystery Disease

Apr 12th, 2020 52m 54s

Bryson seems like a perfectly healthy baby. But soon doctors confirm his parents’ worst fears: something is wrong with Bryson’s brain. Despite dozens of tests over nearly a decade, doctors come up empty in their efforts to find a diagnosis.Fo

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