This episode features Dr. Robert Wood discussing the results of a trial of oral immunotherapy with a manufactured peanut protein product for peanut desensitization, and its potential role in clinical practice. Dr. Nancy Sokol hosts.Dr. Wood i

Digoxin levels and mortality in patients with atrial fibrillation

May 23rd, 2018 15m 6s

Dr. Leonard Ganz discusses pharmacologic rate control of atrial fibrillation (AF) and findings of a recent study published in the Journal of the American College of Cardiology regarding the use of digoxin and mortality in patients with AF. Dr.

PERC criteria for ruling out pulmonary embolism

May 15th, 2018 20m 46s

Dr. Christopher Kabrhel discusses the PERC rule for evaluating patients with suspected pulmonary embolism and a trial exploring the effects of implementing the PERC rule in emergency departments in France, published in JAMA in February 2018. Dr

Under-recognition of fetal alcohol spectrum disorders

May 8th, 2018 13m 57s

This episode features Dr. Carol Weitzman discussing a recent study showing a higher incidence of fetal alcohol spectrum disorders in children than previously thought, as well as methods to raise awareness and improve detection. Dr. April Eichle

Time window for mechanical thrombectomy after acute ischemic stroke

May 1st, 2018 15m 32s

This episode features Dr. Jose Biller discussing two recent studies showing that intra-arterial mechanical thrombectomy improves neurologic outcomes when performed up to 24 hours after symptom onset for selected patients with ischemic stroke. D

Indications for surgery after a first episode of acute diverticulitis

Apr 24th, 2018 11m 26s

Dr. John Pemberton discusses a cohort study of patients with acute diverticulitis followed for 4 years for recurrence rates and need for surgery following the initial episode, published in Diseases of the Colon & Rectum in March 2018. Dr. Nancy

Catheter ablation for atrial fibrillation with heart failure

Apr 17th, 2018 15m 55s

Dr. Brian Olshansky discusses a paper in the February 2018 New England Journal of Medicine regarding a trial of catheter ablation for atrial fibrillation with heart failure. Dr. Nancy Sokol hosts.Dr. Olshansky is Professor Emeritus of Interna

Vaccination to prevent herpes zoster

Apr 10th, 2018 13m 53s

This episode features Dr. Kenneth Schmader discussing new guidelines from the Advisory Committee on Immunization Practices regarding the herpes zoster vaccines. Dr. Sadhna Vora hosts.Dr. Schmader is a Professor of Medicine and Chief of the Di

Partially closed loop glucose monitoring in children and adolescents with type 1 diabetes

Apr 3rd, 2018 14m 11s

This episode features Dr. Joseph Wolfsdorf discussing advances in devices to manage children and adolescents with type 1 diabetes. Dr. Sadhna Vora hosts.Dr. Wolfsdorf is a Professor of Pediatrics at Harvard Medical School and Director of the

Third dose of MMR vaccine for prevention of mumps in an outbreak setting

Mar 27th, 2018 15m 54s

This episode features Dr. Sheldon Kaplan discussing the use of a third dose of the MMR vaccine for the prevention of mumps in an outbreak setting. Dr. Jennifer Mitty hosts.Dr. Kaplan is Professor of Pediatrics and head of the Pediatric Infect

Naltrexone versus buprenorphine for opioid use disorder

Mar 20th, 2018 16m 25s

This episode features Dr. Andrew Saxon discussing treatments for opioid use disorder. Dr. Jennifer Mitty hosts.Dr. Saxon is a Professor in the Department of Psychiatry and Behavioral Sciences at the University of Washington in Seattle, and he

Monoclonal antibodies to prevent migraine; Oral fecal microbiota transplant for C. diff infection

Mar 6th, 2018 29m 32s

Today’s episode of UpToDate Talk features Dr. Jerry Swanson discussing novel monoclonal antibody therapies to prevent migraines, and Dr. Ciarán Kelly discussing oral fecal microbiota transplantation for the treatment of C. difficile infection.

Edoxaban vs low molecular weight heparin in cancer-related VTE; New treatment for cystic fibrosis

Feb 20th, 2018 25m 38s

Today’s UpToDate Talk episode features discussions related to three papers published in the New England Journal of Medicine. Dr. Jess Mandel discusses anticoagulation options for cancer-associated venous thromboembolism, and Dr. George Mallory

Management of suicide risk in children and adolescents; Increasing prevalence of syphilis in the US

Feb 6th, 2018 38m 24s

Today’s episode of UpToDate Talk features Dr. Gregory Simon discussing the management of suicide risk in children and adolescents, and Dr. Khalil Ghanem discussing the increasing prevalence of syphilis in the United States. The second segment b

Frequency for dosing of oral iron; Risk of late recurrence after endocrine therapy for breast cancer

Jan 23rd, 2018 31m 4s

In this episode of UpToDate Talk, Dr. Stanley Schrier joins us to discuss an article from Lancet Haematology on a new paradigm for the dosing of oral iron, and Dr. Dan Hayes discusses his meta-analysis from the New England Journal of Medicine o

Revised recommendations for endoscopy in dyspepsia; New hypertension criteria in ACC/AHA guidelines

Jan 10th, 2018 37m 54s

This edition of UpToDate Talk features Dr. Nicholas Talley, who joins us to discuss the evaluation and management of dyspepsia in adults, and Dr. William White, who discusses the new ACC/AHA guidelines for the evaluation and management of high

PFO closure for prevention of recurrent stroke; Cost-effectiveness of triple therapy in RA

Dec 13th, 2017 28m 6s

This episode of UpToDate Talk begins with Dr. Scott Kasner, who outlines three recent NEJM studies investigating the effects of PFO device closure on recurrent stroke risk. The second segment features Dr. James O’Dell, discussing the cost effec

PFO closure for prevention of recurrent stroke; Cost-effectiveness of triple therapy in RA

Dec 13th, 2017 28m 6s

Investigational gene editing in human embryos to prevent disease; Tests for diagnosis of influenza

Nov 29th, 2017 30m 49s

This episode features Dr. Benjamin Raby discussing a recent paper on correcting a pathogenic gene mutation in human embryos, and Dr. Martin Hirsch discussing testing for diagnosing influenza. Dr. Nancy Sokol hosts.

Prevention of HIV in high risk adolescents; ICDs for treatment of nonischemic cardiomyopathy

Nov 15th, 2017 30m 37s

This episode features Dr. Kenneth Mayer, discussing use of pre-exposure HIV prophylaxis for high-risk adolescents, and Dr. Samuel Lévy, discussing use of an implantable cardioverter defibrillator for the primary prevention of sudden death in pa

Zika virus prenatal infection and birth outcome; Evaluation for occult cancer in unprovoked VTE

Nov 1st, 2017 23m 2s

This episode features Dr. Karin Nielsen discussing maternal Zika virus and potential factors associated with birth outcomes, and Dr. Jess Mandel discussing screening for occult cancer in patients with unprovoked venous thromboembolism. Dr. Jen

Choice of basal insulin for management of diabetes; Evaluation of children with febrile seizures

Oct 18th, 2017 32m 28s

In this episode, Dr. David Nathan discusses choice of basal insulin for management of type 1 and type 2 diabetes, and Dr. Douglas Nordli, Jr., discusses evaluation of children with febrile seizures. Dr. Nancy Sokol hosts.

Guselkumab and tildrakizumab for plaque psoriasis; Two new investigational therapies for hemophilia

Oct 4th, 2017 35m 30s

This episode features Dr. Kristina Callis Duffin discussing the efficacy and safety of guselkumab and tildrakizumab in patients with moderate to severe plaque psoriasis, and Dr. Amy Shapiro discussing emicizumab prophylaxis in hemophilia A with

Revised follow-up for solitary pulmonary nodule; Safe sleep practices and SIDS

Sep 20th, 2017 33m 20s

This podcast features Dr. Steven Weinberger, discussing new guidelines on the management of solitary pulmonary nodules, and Dr. Michael Corwin, discussing interventions to promote safe sleep practices for infants and decrease the incidence of s

Sentinel lymph node metastasis in melanoma; Transcranial electrical stimulation for depression

Aug 31st, 2017 31m 39s

This episode features Dr. Michael Atkins discussing the management of positive sentinel lymph nodes in patients with cutaneous melanoma, and Dr. Peter Roy-Byrne discussing an investigational transcranial therapy for individuals with depression.