Dot Weir, RN, CWON, CWS and Catherine Milne, APRN, MSN, ANP/ACNS-BC, CWOCN-AP review the normal healing process and pathophysiology of non‐healing wounds, apply evidence‐based methods of wound bed preparation and dressing based on clinical assessment, examine current treatment modalities for wound care highlighting compression therapy, negative pressure wound therapy, advanced wound care dressings, and skin protectants, and determine when and on which types of wounds to use various advanced wound care modalities.