Karen Laforet, RN, MClSc, CCHN(c), CCVA(c), VA-BC and Kathleen McMullen, MPH, FAPIC, CIC recognize the components of a bundle approach to prevent PIV-BSI, identify the importance of appropriate catheter insertion technique and site protection, discover strategies for dressing and cap selection and application to prevent PIV-BSI, and explain the significance of the bundle approach in reducing PIV-BSI risk.