Jacqueline Daley HBSc, MLT, CIC, CSPDS, FAPIC and Franklin Dexter, MD, PhD, FASA explain the importance of the triad of patient preparation in reducing surgical site infections (SSIs) and complications, explore the clinical evidence supporting the use of nasal decolonization, skin preparation, and incisional drapes in SSI prevention, explain the economic impact of SSIs and the cost effectiveness of implementing a bundled approach to patient preparation, and develop an action plan for implementing a comprehensive patient preparation bundle in your healthcare facility.