From 18 to 21 September 2012, experts from business and science were discussing the subject of "21st Century Learning for 21st Century Skills" as part of the Seventh European Conference on Technology Enhanced Learning (EC-TEL 2012) on the campus of Saarland University, Saarbrücken. The internationally oriented European Conference on Technology Enhanced Learning (EC-TEL 2012, 18 to 21 September 2012, Saarbrücken) has succeeded in attracting eminent keynote speakers whose contributions enriched the conference programme. Keynote talks have been held by Prof. Dr. Richard Noss (University of London), Prof. Dr. Dr. h.c. mult. Wolfgang Wahlster (German Research Center for Artificial Intelligence), Prof. Dr. Ruimin Shen (Shanghai Jiao Tong University) and Prof. Dr. Mary Lou Maher (University of North Caroline Charlotte).