Endeavor follows the adventures of three Starfleet officers: Lt. Commander Naomi Wildman (who grew up on the USS Voyager), Lt. Dal Lacerto (a Cardassian linguist) and Lt. Kutch (a Tellarite security officer) serving on an exciting mission to explore the Andromeda galaxy with a coalition of other Alpha Quadrant races (Klingons, Romulans, Cardassians). The series places a special emphasis on issues of neurodiversity, queer representation and the depiction of the hopeful, optimistic future that so many people turn to Star Trek to see.

It was created by Ron "AAlgar" Watt and Maggie Rowbotham, co-hosts of the Post Atomic Horror podcast (the only podcast to review the entirety of the canonical Star Trek franchise). Having spent nine years analyzing every movie and TV show, they felt uniquely qualified to deliver their own vision of what Star Trek could be.