Guardians is set in the near future and follows the life of a young girl, Kathy, who suffers a head injury which gives her some amazing psychic abilities, and then, through various extraordinary circumstances, ends up in a small town near Roswell, New Mexico. Along the way, she joins up with Megan, another psychic who is also being drawn to that same town.

When they arrive, Kathy is abducted by a UFO and after some alien technological wizardry, she gives birth to a hybrid baby. In the meantime, the aliens are surprised at how strong the psychic force is in some humans and fear that this power could destroy them, so they use the hybrid baby in a plot to wipe out the entire human race before anyone discovers they are here. Kathy dares to resist them and fights to save her hybrid child.

But in the end, it is the child, himself—half alien / half human—who will determine which race will live, and which will die.