Featuring articles on testosterone treatment and fractures in men, long-term resynchronization–defibrillation therapy for heart failure, azithromycin to prevent infant mortality in Burkina Faso, oral simnotrelvir for adult patients with Covid-19, understanding liability risk from health care AI tools, and the rise of house staff unions; a review article on syphilis during pregnancy and congenital syphilis; a case report of a woman with melanoma and fever; and Perspective articles on responding to medical errors, on looking AHEAD to state global budgets for health care, and on broken both ways.