0:07

here's what my or anyone

0:09

else's opinion is, always

0:12

you care about is , the science

0:15

says what does the best available

0:17

of evidence published in the peer-reviewed medical literature

0:20

have to say right now, welcome

0:22

to the nutrition facts were on

0:25

your host dr michael greger

0:27

i

0:28

know so many people have been diagnosed

0:31

with alzheimer's disease the most common

0:33

cause of dementia i

0:36

bet you do too

0:37

one six million people in the us

0:39

having so we have

0:41

void becoming one

0:44

, those statistics that , thrust

0:46

of my forthcoming book how not the age

0:49

but meanwhile discussion of

0:51

them alone risk factors in

0:53

this our three hundred

0:56

podcast episode

0:58

the never story wish for the effect of

1:01

pesticides on also

1:05

numbers are growing list of all summer suzie

1:07

susceptibility genes even if you put them

1:09

all together they account for less than half

1:11

of all also miss cases the

1:14

single most compelling piece of data on the potential

1:16

control we have over the disease the

1:18

disease you have identical twins with

1:20

the exact same genes even have one gets

1:22

also miss the other usually does not

1:25

so we have to think about all the other contributing

1:27

factors beyond just genetics

1:30

my video on pesticides

1:32

and cancer i started on this study

1:34

and there's a list of chlorinated pesticides

1:37

including dd he metabolite

1:39

of ddt that are classified

1:41

by the be as probable human carcinogens

1:44

been a steady blood levels of dd he

1:46

and others were associate not with increased

1:49

cancer mortality it's been increased risk of

1:51

other cause mortality decide

1:53

researchers to speculate it may be due to an associate

1:56

increase risk of diabetes or

1:58

dementia

1:59

diabetes

2:02

like what about dementia elevated

2:05

soon pass and levels and risk for

2:07

alzheimer's disease

2:10

the research team at rutgers down significantly

2:12

higher blood levels of dd in

2:14

alzheimer's disease patients compared to

2:16

controls an autopsy social

2:18

blood levels are good proxy for brain

2:21

levels those , the highest levels

2:23

ward about four times yards being demented

2:26

with alzheimer's and in a petri dish

2:28

dd increases amyloid precursor

2:30

protein levels in human brain cells providing

2:32

a potential mechanism put

2:34

all these studies together and does indeed

2:37

seem to be a link consistently data

2:39

showing about data showing of risk for developing

2:41

dementia among those acutely pesticide

2:43

point among us elders ddt

2:45

and is breakdown product db are also

2:48

associated with increased risk of cognitive decline

2:50

in general did he was extensively

2:53

used in the united states from the nineteen forties

2:55

to the sixties at it's peak we're returning

2:57

out a hundred and eighty million pounds

2:59

a year and a still in our bodies

3:01

to this day contaminating the bloodstreams

3:04

of more than ninety percent of americans and

3:07

pass , linked to quadruple in the odds of

3:09

alzheimer's read the highest levels

3:12

it sooner bodies because it's still in the

3:14

food supply in my last video

3:16

on the topic i noted that the level of ddt

3:18

dd another band pesticides and plumes

3:21

were much lower and the breast milk from

3:23

a vegetarian mother to her do breastmilk

3:25

over non vegetarian sister and

3:27

the largest difference was noted for dd

3:30

which was four times lower in the vegetarian

3:32

sister these toxins build

3:34

up the foods as so it makes sense of

3:36

the most contaminated foods or me

3:38

this

3:39

dairy products five to ten times

3:42

higher levels in meat eggs

3:44

fishing dairy than what we find in plain

3:47

foods and unfortunately cooking

3:49

doesn't destroy balloons like dd

3:51

infection may make them even more concentrated

3:55

anderson's for a pesticide there may increase

3:57

the risk of alzheimer's disease as much

3:59

as carried the so hold all summers gene

4:02

though he for in

4:04

our next door it we look the role of

4:06

meat on autonomous disease

4:10

behind the dramatic increase in dementia

4:13

in japan over recent decades

4:15

maybe it's rising obesity rates are

4:17

the increases in cholesterol saturated fat an iron

4:20

from increases in animal products

4:22

and meets overall

4:24

calories just went up about ten

4:26

percent in japan where's animal fat and

4:29

meters of zeros five hundred

4:31

percent about ten times the rise

4:33

in sugary junk snub

4:35

, this tension race consumption went

4:37

down but the think he is that rather

4:40

than white race somehow being protected maybe

4:42

there is a seeing something worse instead

4:45

as like when you find fish consumption

4:48

correlate with less disease wonder if it's because

4:50

they're eating that rather than some worse

4:52

meet if you look across

4:55

multiple countries you see a similar pattern

4:57

with the most important dietary linked to alzheimer's

4:59

appearing to be meat consumption

5:01

with eggs and dairy also

5:04

may be contributing nurtures to be

5:06

a really tight correlation between alzheimer's

5:08

per capita meet supply and

5:11

then studies within countries uncover

5:13

similar findings with alzheimer's and cognitive decline

5:15

associated with midi sweetie

5:18

that he die and swears

5:21

most plant foods were so say with risk reduction

5:24

this , be for a variety of reasons animal

5:27

products and mm copper mercury lead

5:29

cadmium know full late but contained

5:31

saturn found closed off and pro

5:34

inflammatory advanced education and products

5:36

so many mechanisms many dietary modifications

5:39

may be our best bet for reducing

5:41

risk of alzheimer's disease how

5:44

do we know it's clause in the senate

5:46

and the evidence and meat consumption is causally

5:49

linked to alzheimer's seats

5:51

mother's the strength of the association that consistency

5:53

across different studies the fact

5:56

that the dietary changes preceded

5:58

the risk and demented the dos reis the more

6:00

meat linked to more risk a bunch

6:03

of plausible mechanisms of we know

6:05

meters respect for other chronic diseases

6:07

but it's never been a randomized controlled trial

6:10

to put it to the test when

6:12

you read reviews of the damaging effects

6:14

of high fat diet to the brain and

6:16

cognition a , of factors

6:18

are proposed to council high fat diet induced

6:20

damage to the brains oxidative stress

6:23

insulin resistance inflammation and change

6:25

the blood vessels of the integrity of the blood

6:27

brain barrier but these sir

6:29

based mostly on studies of

6:32

rodents yes

6:34

i said dies because energy dysfunction

6:36

in the brain based on seen

6:38

based on or i'd techniques with city

6:40

scans you can follow this intracranial

6:43

arteries to know says his brain artery

6:45

clogging overtime and father

6:47

progression from mild cognitive impairment the

6:49

all terms disease those

6:51

, only had low grades to noses

6:53

are pretty stable over time in terms of their

6:55

cognitive functions and ability

6:58

to dress themselves and other activities of daily living

7:00

whereas those with more clogging started

7:02

slipping over the years and those

7:04

who started out with the most brain atherosclerosis

7:07

rapidly went downhill and

7:09

twice as likely to progress to

7:12

full blown alzheimer's chronic

7:15

consumption standard western diets enriched

7:17

and saturated fat, and cholesterol make compromise are

7:20

cerebrovascular integrity compromised

7:22

the blood vessels in our brain show,

7:25

of course, are

7:27

recommended for mukwonago modulation

7:29

of died, induce dysfunction, but

7:32

why not tried to eat healthier

7:35

in the first place finally,

7:38

today, we look at reducing blanco

7:40

toxin intake to ward

7:43

off of hammers

7:44

each of us has about six billion

7:47

miles of dna how

7:49

does a body keep from getting all

7:51

tangled up their special proteins

7:54

called stones which act like spools

7:56

with dna as the thread enzymes

7:59

called thirty one wrap

8:01

the dna around the histone spools

8:04

and in doing so silence whatever

8:06

genes were in that stretch of

8:08

dna and surname sir twins

8:10

which stands for silencing information

8:12

regulator although , were

8:14

discovered only about a decade ago

8:16

the study of certain ones has become one of the most promising

8:19

areas of biomedicine says they

8:22

peered be involved in promoting healthy

8:24

aging and longevity suppression

8:27

of this see host defense is concerned

8:30

a central feature of alzheimer's

8:32

disease autopsies

8:34

of all time as victims are reveal that loss

8:37

of sir to an enzyme activities closely

8:39

associated with the simulation of plaques

8:41

and tangles in the brain that characteristic

8:44

of all summers disease sir

8:46

twins appeared activate pathways

8:48

that steer the brain away from

8:50

the formation of plaque untangle proteins because

8:53

a decrease in certain activities can

8:55

clearly have deleterious effects

8:57

on nerve health they're trying to come up with

9:00

drugs serb increase or to an activity

9:02

but why not just prevent

9:04

it suppression in the first

9:06

place like go

9:08

toxins in food suppress

9:11

sir to an activity the so called advanced

9:13

location and products or age ease

9:16

our modern died includes excessive

9:18

eg ease which can be neurotoxic

9:21

high levels in the blood may

9:23

predict cognitive decline

9:25

over time if

9:27

you measure the urine levels of geico toxins

9:30

flowing through the bodies of older adults those

9:32

with the highest levels went on to

9:34

suffer the greatest cognitive decline

9:37

the subsequent nine years

9:40

and as we age or brain

9:43

literally shrinks in

9:45

, sixty seventies we're losing average

9:48

of five cubic centimeters of total brain

9:50

tissue volume every year year

9:52

some lose more than others

9:56

brain atrophy may be reduced

9:58

and very healthy individuals

10:00

in a few people don't lose any brain

10:03

at all normally we lose

10:05

about two percent of brain volume every year but

10:07

that's just the average although the

10:10

average brain loss for folks in her seventies

10:12

and eighties was two point one percent some

10:14

lost more some last last

10:17

and some men and women lost none

10:19

at all over a period of four years

10:22

researchers in australia provided the first

10:24

evidence linking eg ease with this kind

10:27

of cerebral brain laws so

10:30

a limiting ones consumption of these compounds

10:32

may end up having significant public

10:34

health benefits the

10:37

biggest or twin deficiencies both

10:39

preventable and reversible by

10:41

dietary agee reduction a

10:43

therapeutic stretch it includes eating less

10:46

eg ease mail for new strategy

10:48

to combat the epidemic of

10:50

all time some

10:53

of these are geico toxins are produced internally

10:56

particularly in diabetics but anyone can get

10:58

them from smoking and eating particularly

11:01

foods high in fat

11:03

and protein in , previous

11:05

video i listen to the fifteen foods

11:08

most contaminated with

11:11

glycol texts mostly

11:13

chicken but also pork beef and fish

11:16

she may help explain why those that eat the most

11:18

meet may have may triple

11:20

the risk of getting dementia compared

11:22

to long time vegetarians we

11:25

would love it if you could share with us

11:27

your stories about reinventing your health

11:29

through evidence based nutrition good

11:31

nutrition facts dot org slash testimonials

11:34

we make sure it on our social media to help

11:36

inspire others gretchen

11:39

graphic images are studies mentioned here

11:41

please go to the nutrition facts podcast

11:43

landing page of the stereo find all

11:45

the detailed information he needs to

11:47

links to all the sources we signed

11:49

for please stop for

11:52

apparently text on the pathogens the cause

11:54

pandemics you order the

11:56

book audiobook or hard copy of my last

11:59

book how this

11:59

by a pandemic

12:01

four recipes check out my second

12:04

the last book how , to die

12:06

yet to cook book book beautifully

12:09

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12:11

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