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The failed promise of egg freezing

The failed promise of egg freezing

Released Monday, 29th April 2024
 1 person rated this episode
The failed promise of egg freezing

The failed promise of egg freezing

The failed promise of egg freezing

The failed promise of egg freezing

Monday, 29th April 2024
 1 person rated this episode
Rate Episode

Episode Transcript

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0:03

Have you ever wanted to freeze time

0:08

to preserve life? For

0:12

the past 12 or so years, the

0:14

option of freezing eggs has been popular

0:16

for women who may want kids but

0:18

don't want them right now. If the

0:20

perennial question is, can women have it

0:23

all, could the

0:25

answer be egg freezing? Some

0:27

companies even started to offer to pay for

0:29

the procedure, on average about $11,000 per

0:32

cycle, as a perk of employment. With

0:34

the great resignation and full swing, it's

0:36

become hard for companies to hang on

0:38

to their people. And so

0:40

now we're seeing egg freezing, IVF

0:43

and others emerging as

0:45

a whole new category of benefits up for grabs.

0:47

And now, a dozen years on, we're getting

0:50

the data on how well this process has

0:52

been working for women and for families, and

0:54

those outcomes are coming up on Today Explained.

1:00

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cable provider and kindly demand today

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explained. My

2:32

name is Anna North.

2:34

I'm a senior correspondent for vox.com, where

2:37

I cover American family life, child care,

2:39

education, and a whole lot of other

2:41

things. You recently wrote

2:44

a piece for Vox about women freezing

2:46

their eggs. And you noted

2:48

in this piece that women sometimes

2:51

talk about freezing their eggs as kind

2:53

of an insurance policy against time.

2:56

You know, I freeze now and then I

2:58

fertilize when it's convenient. Is

3:01

it working the way we seem to think it is working?

3:03

We now have more data than ever about

3:06

the effectiveness of egg freezing. And while it

3:09

is working for some people, and you know, some

3:11

people go and have a great experience, it

3:13

has failed to live up to some of its early

3:16

hype. I think at the beginning, you

3:18

know, it was thought this was going

3:20

to usher in this new era of

3:22

gender equality. Tech giants Facebook and Apple

3:25

confirming they will pay for female employees

3:27

to freeze their eggs, telling ABC News

3:29

we want to empower women at Apple

3:31

to do the best work of their

3:33

lives. It seemed sort

3:36

of careless of me not to take advantage of

3:38

the fact that I can't stop myself from aging.

3:40

I can't fall in love

3:43

overnight, but I am

3:45

able to stop the aging of my eggs.

3:47

It's going to free people to pursue

3:49

careers in a really different way. But

3:52

now there are a lot of concerns with

3:54

some experts saying this procedure really just serves

3:56

as another way for companies to make money

3:59

from stoking women's anxieties. What

4:02

was the promise? Like, if you could boil it

4:04

down to a few words, when women were sold

4:06

on freezing their eggs, what were they told? Around

4:09

2014, when this procedure was really becoming

4:11

more mainstream, there was a thought that

4:13

it would be as big as the

4:15

birth control pill in terms of how

4:17

much it would change people's lives. And

4:19

then there's this really famous 2014 Bloomberg

4:22

Businessweek cover story that used the phrase,

4:24

freeze your eggs, free your career. In

4:27

a world in which life isn't dictated by

4:29

a biological clock, if a 25-year-old banks

4:32

her eggs and 35 is up for

4:34

a huge promotion, she can go for

4:36

it wholeheartedly without worrying about missing out

4:38

on having a baby. So there

4:41

was this idea it's going to upend

4:43

gender roles, it's going to upend, you

4:45

know, the way that women might be

4:47

discriminated against in the workplace. Indeed,

4:49

if you look at the dominant marriage

4:51

strategy in 1980, it was for men

4:53

to delay their parenthood and then marry

4:56

and impregnate younger women. Now

4:58

in the 2010s, we actually

5:00

have a more gender equitable strategy

5:02

where both partners can invest in

5:04

themselves and delay. It's going to

5:06

change everything almost the way that birth

5:09

control changed everything in the 1940s. The

5:15

first successful births from frozen eggs were actually all

5:17

the way back in 1986, a pair

5:20

of twins born in Australia. That

5:22

turned out to be kind of difficult to replicate for

5:25

a long time. So egg freezing

5:27

doesn't really take off until the 1990s

5:29

starting at a clinic in Italy. So

5:32

the Italian government was about to pass a law

5:34

restricting the use of frozen embryos. So

5:36

that's when the egg is fertilized with sperm and starts to

5:38

grow. Restricting the use of

5:40

frozen embryos on the ground, they constituted human

5:42

life. And so freezing

5:44

the eggs instead became a way to

5:46

get around this law and still treat

5:48

patients with infertility. When

5:50

we fast forward a little bit in the

5:53

early 2000s, the procedure starts to spread more

5:55

to the United States, around the world. Probably when

5:57

this comes into its own, it will be more

5:59

liberal. to women than the

6:02

oral contraceptives were back in the 1960s.

6:05

A lot of people who were freezing

6:07

their eggs had a medical condition that

6:09

really made it necessary in some ways

6:12

to preserve fertility. So for example, people

6:14

who were about to undergo chemotherapy

6:16

for cancer, which might impact

6:19

their fertility. It starts to really get

6:21

a lot of mainstream interest in 2012

6:23

when the American Society for Reproductive Medicine

6:25

announced it should no longer be considered

6:27

experimental. It said babies born from frozen

6:29

eggs are as healthy as those from

6:31

fresh eggs, but the committee said the

6:33

procedure should be limited in its use.

6:36

In 2012, what really changed is

6:39

people started to freeze their eggs more

6:41

because they weren't in a position to have children

6:43

right then. They didn't necessarily have a medical condition,

6:46

but they hadn't met the right partner,

6:48

there were career concerns. I thought

6:50

it would be really nice if I could make

6:53

it so that I had a baby when my

6:55

life was ready instead of just because my body

6:57

is ready. So there's this big change in the

6:59

way that egg freezing was used. How

7:04

does this process actually work? The procedure starts

7:06

with 10 to 14 days of hormone injections,

7:08

often two or three per day, to kind

7:11

of stimulate the ovaries to produce more eggs

7:13

than normal. Typically, in

7:15

a cycle, the body is producing

7:18

one, maybe two eggs, but in

7:20

order to harvest eggs for egg freezing, you want the

7:22

ovaries to make a bunch more. So you're taking these

7:24

medications, you're either injecting them yourself, if

7:26

you have a partner, you can get the partner to do

7:28

it, you can get a friend to do it, but it's

7:30

needles. And then you're

7:33

typically going to a clinic two to three

7:35

times a week for ultrasounds, blood work, you're

7:37

monitoring the whole process. Finally,

7:40

when the eggs are the right size, the doctor says you're ready,

7:42

you take another injection, a

7:44

trigger shot, that's designed to complete

7:46

that maturation process. About

7:48

36 hours after that trigger shot, and this

7:50

has to be timed really well, you'll go

7:52

in, a doctor will extract

7:54

the eggs using a needle that actually

7:57

threads up through the vagina into the

7:59

ovary. And, you

8:01

know, it's not a super

8:03

risky procedure, but there's a small risk.

8:05

There can be complications. You

8:07

can experience blood clots. You can have something

8:09

called an ovarian torsion, which is as bad

8:12

as it sounds. But if everything

8:14

goes well, if you're under 38, you

8:16

might get between 10 and 20 eggs. And

8:20

then they put the eggs on liquid nitrogen.

8:22

They put them on ice. And

8:25

you basically store them away until at some point maybe

8:27

you want to use them. Okay.

8:29

So you just walked us through what it's like

8:31

to do that process one time. What

8:33

would that one time cost? It's a lot of money,

8:36

usually five figures. Wow. Between $10,000 and $15,000 a cycle,

8:38

one patient I talked to, she froze her eggs in

8:40

2022. So

8:45

pretty recently cost her about $14,000. And

8:49

that included some storage fees. Now

8:51

storage fees are going up. They

8:54

can be about $800 a year or more. So

8:56

you do that initial 10K-ish round, right? But

9:00

you're still paying in the hundreds

9:02

every year to keep those eggs and

9:04

make sure they're safe for when you might want to use

9:06

them. One of the big promises,

9:08

as you've laid out, is that freezing your

9:10

eggs allows you time to

9:13

do things at your own pace. Is

9:17

that true? How long do a

9:19

woman's eggs actually remain viable once they've

9:21

been frozen? The freezing

9:23

process has gotten better over time. But

9:27

eggs contain a lot of water. So

9:30

they're a little harder to freeze than

9:32

some other tissues in the human body,

9:35

including actually fertilized embryos. So

9:37

there's going to be some potentially that are lost when

9:39

you saw them. It's not a perfect process. It's

9:42

also the case that your

9:44

own body, you can't necessarily support a

9:46

pregnancy forever. So at a certain point,

9:49

if you're looking at after 45, things

9:51

like this, it might be harder and

9:53

harder to be pregnant. It's

9:55

less about how long the eggs Last

9:58

once, they're frozen and more.. About

10:00

how old were you when you frozen

10:02

and how good quality were they when

10:04

they were frozen and how many where

10:07

they you know if you only for.

10:09

As for. Then you

10:11

gotta hope that. One. Of

10:13

those fertilizers, it's just it's a numbers game.

10:16

Okay, so we have an expensive

10:18

process and typically things do things

10:20

like this to get cheaper overtime.

10:22

They go from being like a

10:24

super rare thing to more com

10:26

and this has become a huge

10:29

growth industry. Didn't you talk us

10:31

through the process of being very

10:33

rare to it being. Highly

10:35

available to to anybody. last five

10:38

figures. Soon. Twenty Twelve After

10:40

the American Society Reproductive Medicine says this

10:42

is no. longer, experimental. From there we.

10:44

Can I get this explosion and media

10:46

coverage? And so now we're seeing Egg

10:48

Freezing or National Medical Group decided that

10:50

freezing eggs are selling a lot of

10:52

promise and them are also seeing these

10:55

new companies spring up specifically to to

10:57

offer a market. Egg Freezing is. Kind

10:59

by the is reinventing the women's health

11:01

care experienced modern. Fertility

11:04

which has long since when he sixteen

11:06

offered Instagram influencers reduced rates in exchange

11:08

for posting about egg freezing and there

11:11

was a quote unquote Fertility Studio called

11:13

Trellis ah that open in the flat

11:15

iron in Manhattan and twenty teen called

11:17

us off the equinox of egg freezing

11:20

the sort of kind body which is

11:22

also launched and twenty a team had

11:24

like parties of drinks and scented candles.

11:27

The women invited to this party all

11:29

have something in common. they're successful in

11:31

their careers with no immediate plans to

11:33

have children's but they know their eggs

11:36

will never be as healthy as they

11:38

are now. I feel like there's a

11:40

lot of pressure to find the right

11:43

person and the clock is ticking and

11:45

you don't wanna be resting. Nine Eleven

11:47

companies would have kind of a distinctly

11:49

like millennial twenty hens ethos and is

11:52

hagglund like plan your path or it's

11:54

really about like empowerment and women's empowerment.

11:56

There was a girl boss vibe I

11:58

think to this. It's

12:02

just about hanging out and realizing that

12:04

you're not alone. There are a lot

12:06

of women out there just like you.

12:08

Who are you targeting specifically? Anyone with

12:10

a question about whether egg freezing is

12:12

for them? And we do get

12:15

this real skyrocketing popularity, so the

12:17

figure that I've seen is about 2,500 people

12:19

were freezing their eggs in 2012, and by 2020, that was 13,000.

12:35

Boxes Anna North, she'll be back along

12:37

with writer Maymay Fox, who was among

12:39

the thousands of women who were told

12:41

that freezing eggs was a way to

12:43

buy them more time. Mimi's

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always wanted to have children my entire

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life, and I love being

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around kids. I desperately want

16:44

to have my own, but I have gone through

16:46

a divorce when I was in my early 30s

16:50

that left me single at this stage of

16:52

my life. I

16:55

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Brokaw, and we went into the

17:00

office of a fertility doctor, Dr.

17:03

Jamie Griffo at NYU, to

17:05

interview him about fertility issues.

17:09

And at this point, I'm 37 years old, and I'm in

17:11

excellent health. So

17:14

I'm just thinking that I'm not going to

17:16

have any trouble getting pregnant if and when

17:18

I finally meet the love of my life.

17:22

So we go into the office, and

17:24

he sits us down at a table,

17:26

and he shows us a chart. This

17:29

is a graph that illustrates

17:32

the rate of infertility of

17:35

women after the age of 35. And

17:38

it isn't a gradual

17:40

decline in fertility, as I had imagined.

17:43

It is an exponential curve.

17:45

So with each passing month

17:48

after the age of 35, your

17:50

chances of conceiving a child are

17:53

exponentially less. And I'm able

17:55

to ask Dr. Griffo, well, what about me?

17:57

I'm in perfect health. I do yoga. I

17:59

eat well. like I've never been a

18:01

smoker, like this isn't true for me, right?

18:04

And he's just like, no, that has nothing

18:06

to do with it. These eggs have been

18:08

in your body since you were born. And

18:11

this is a degradation that happens to every

18:13

woman as a result of age. I

18:18

am shocked and

18:20

devastated. And my eyes are wide. And then

18:22

we're talking to him about what are your

18:24

options. And one of

18:26

the options at this time was still

18:29

considered an experimental procedure, freezing your eggs.

18:34

I wanted to have children with a partner.

18:36

But I was single,

18:38

and I didn't have a partner. So I was

18:40

like, gosh, I better freeze my eggs. There

18:43

was starting to be a lot of

18:45

chatter in the media. And there are

18:47

people like there were women throwing egg

18:49

freezing parties. And it

18:51

was very much seen as

18:54

your insurance policy. Why

18:57

wouldn't you do this? Why wouldn't you

18:59

go get insurance? If you have

19:01

a choice, if you have, you know, it's medically you're

19:03

able to do it and financially you're able to do

19:05

it, why wouldn't you? So

19:12

I scratched up $10,000. So a lot

19:14

of money for me at the time.

19:16

And I went through the process of

19:18

freezing my eggs. And it

19:20

was very successful. I was told I

19:23

had 18 frozen eggs. It

19:25

was a terrific number

19:28

for my age. They all looked

19:30

healthy. I had really great hormone

19:32

numbers and everything looks strong. So

19:35

I had my insurance policy. That

19:38

piece of it was really important

19:40

to me that psychologically at

19:42

that point, I relaxed a

19:45

little bit about the ticking clock. And

19:47

I was able to go

19:50

back to dating with more

19:52

confidence and more calm

19:55

and more presence to just like, let's

19:58

enjoy this process. instead of being in

20:00

a blind panic about, oh my God, I

20:02

have to meet a guy so I can get married

20:04

and have kids. Shortly

20:07

thereafter, went to Costa Rica to learn

20:09

to surf and to write, and I

20:11

met the love of my life, my

20:13

husband, Kiran Ramchandran. And

20:16

it still took us a

20:18

few years to get together. We

20:21

were both involved in sort of

20:23

on-again, off-again relationships. And eventually, three

20:25

years later, I moved down to

20:28

LA, and we decided

20:30

to get married and immediately start trying to

20:32

have kids, because I was rapidly

20:34

approaching my 40th birthday, and he was

20:36

a little bit older, at 42. We

20:40

got pregnant, we were

20:42

thrilled over the moon, and

20:44

then I miscarried, which was

20:46

devastating. And at that point,

20:48

we went in to see the fertility doctor in

20:50

LA, and he said, "'Look,

20:53

why don't you use those frozen eggs?

20:55

"'This is the perfect opportunity.'" And

20:59

I thought, that's a great idea, let's do

21:01

it. So we arranged for them to be

21:03

shipped from Stanford facility

21:05

in San Francisco down to

21:08

LA. And

21:10

the morning that my eggs arrived in Los

21:12

Angeles was the worst day of my life.

21:19

I get a call from the fertility doctor,

21:22

and he says, I've bad news.

21:25

Are you sitting down? All

21:28

your eggs were destroyed in

21:31

shipping. And

21:33

as you might imagine, my

21:36

first reaction was just confusion. I

21:38

asked a million questions. Why,

21:41

what happened? He said, well, it looks

21:43

like they were misspacked. I

21:46

was like, what are you talking about? He said, do you wanna

21:48

come in and see? And I said,

21:50

absolutely. So, Ciaran and I

21:53

drove to the doctor's office in LA,

21:55

and he showed us these vials where

21:57

the tops had not been appropriate. at

22:00

least sealed, it had not been packaged. So if you

22:02

can imagine taking eggs that you

22:04

buy from the store and instead of

22:06

them being carefully packaged in cartons that

22:08

protect them during shipping, they're just kind

22:10

of all tossed into one bin together.

22:13

I was so heartbroken. I

22:16

mean, I really cried

22:18

and felt angry at the universe

22:23

and had to do a lot

22:25

of work to get past it. One

22:31

of my decisions actually was to

22:33

file a lawsuit against Stanford for

22:36

medical negligence. And

22:38

we actually did file a lawsuit and it went

22:40

to court and the judge threw it out because

22:42

he said it was an experimental procedure. No

22:46

one told me there was any risk involved

22:49

in shipping and that would have been so

22:51

easily solved. I mean, I was in LA

22:53

and I could have easily

22:56

flown up to San Francisco and

22:58

had the procedure done

23:00

entirely there if I had been told

23:02

that there was a risk in shipping, which I was

23:04

not. That

23:11

was Maymay Fox. She's a New York Times

23:14

bestselling author and editor and a contributor

23:16

to Forbes. All right, Vox's Anna

23:18

North is back with us now. So Anna

23:20

Maymay was a source in your Vox story

23:23

about egg freezing. That's how we met her.

23:25

Can you tell us how common stories

23:28

like hers really are? She's

23:30

not the only person to have encountered

23:32

problems with egg transportation or egg storage.

23:34

There was a 2022 study that found at least

23:37

nine storage tank failures over 15 years affecting

23:40

1,800 patients. And

23:42

then, you know, those are sort of the

23:45

technological problems. These are accidents, maybe things that

23:47

wouldn't be expected. But

23:49

egg freezing patients also kind of have to

23:51

contend with the fact that the human body

23:54

itself is unpredictable, even with this

23:56

new technology. So there's just

23:58

really a lot of points at which egg freezing can be. fail

24:01

and the doctor who studies this really walked me through

24:03

it. First of all, the ovaries

24:05

might not produce enough eggs. Even with the medications that

24:07

are supposed to make them do that, the

24:10

eggs might not survive the freezing process. When

24:13

they're thawed, they might not fertilize

24:15

properly. And then if

24:18

they're fertilized, those embryos might not

24:20

implant properly in the uterus. So,

24:22

you know, just like with anything around pregnancy

24:25

and fertility, there's a lot of uncertainty is

24:27

really baked into the process. Are

24:29

any of these companies able to tell you or is

24:31

any of the data able to tell you like how

24:35

frequently this happens? So is it possible to

24:38

say if you freeze your eggs about half

24:40

the time, it's not going to result in

24:42

a viable pregnancy? Do we have numbers like that?

24:45

Increasingly, we have data. There's a 2022 study

24:48

out of NYU that got a lot

24:50

of attention. They found that the chance

24:52

of a live birth from frozen eggs

24:54

overall was about 39%. Now, that

24:58

chance goes up if the

25:00

person is younger when they freeze eggs. And it

25:02

also goes up the more eggs you freeze. So

25:05

if you freeze a lot, you have a better

25:07

chance of some of them fertilizing and becoming viable.

25:10

But what the study author Sarah Cascante told me

25:12

is there isn't a guarantee of having a baby

25:14

from egg freezing. Would

25:17

you characterize it as a necessary thing to

25:19

do or who would it be necessary for?

25:21

I think it's so complicated. When I talked

25:23

to doctors, there sort of was a sweet

25:25

spot of like a person that they might

25:27

counsel to consider egg freezing. But,

25:31

you know, that person is not 22, right?

25:33

Because someone who's quite young, they have

25:36

a lot of time to build their

25:38

life in different ways. They have a lot of

25:41

time to conceive without assistance. There's

25:43

not really a need, even though there are some

25:45

companies that have marketed to very young people about

25:47

this. There's not really a need, a

25:49

lot of experts told me, for someone who's quite

25:52

young to go through this whole process that costs

25:54

thousands of dollars, that involves giving yourself shots, that

25:56

involves some risk of getting sick, you know, for

25:58

something that they're probably not going to eat. use.

26:01

Even for people who freeze their eggs, they're

26:03

not typically going back and using them.

26:05

Only about 12% of patients worldwide actually

26:08

go back to use those frozen eggs.

26:11

So a lot of times they're

26:13

conceiving without assistance or they're

26:15

deciding not to become parents or maybe

26:17

they're becoming parents through adoption or they're

26:20

becoming parents through partnering with someone who

26:22

has children of their own. You know,

26:24

it's, it's something that I do

26:26

think a lot of people like to have and

26:28

people who freeze their eggs typically report kind of

26:30

a feeling of empowerment and a feeling like

26:32

their stress levels went down. They did something

26:34

for themselves, but it's actually not something

26:36

that people are using biologically for

26:39

the most part to build their families.

26:45

All of that was really a dark,

26:47

dark period in my life. I will

26:49

say that the good news is we

26:51

went on to do

26:53

several rounds of IVF and on

26:55

the third round we were successful

26:58

and not only that, but we tried

27:01

for twins and we succeeded and

27:03

I now have beautiful, healthy twin

27:05

boys. So the story has a

27:08

happy ending, but it

27:10

was definitely not what I expected. That

27:27

was Mae Mae Fox. We're all very happy for

27:29

her. And you also heard from Vox senior

27:31

correspondent Anna North. Victoria Chamberlain produced

27:33

today's show and Amina El-Sadi

27:35

edited Patrick Boyd engineered facts

27:38

by Laura Bullard. Amna-Well King,

27:40

it's today explained. you

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