Bishnu Subedi
'Why we do What we do in Cardiology'Episodes
Episodes of 'Why we do What we do in Cardiology'
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2024 HCM Guidelines Focus on Cardiac Myosin Inhibitors and ExerciseMavacamten: Class 1 recommendation for symptomatic obstructive HCM.Exercise: Now allows for "vigorous" activity; competitive level still limited.Pediatric Section: Separ
Key Points: Positive Aspects of DOACs: DOACs are acknowledged for their convenience, efficacy, and safety in conditions like atrial fibrillation (AF) and venous thromboembolism (VTE). The review supports their use in stroke prevention, AF, re
Background: Traditional practice requires fasting before cardiac catheterization, but there's no evidence to support it.Objective: This study compared a heart-healthy pre-procedure diet with fasting to determine best practices.Methods: 197 pa
Key PointsIn patients not taking antianginal meds, PCI alleviated some—but not all—symptomsBackground:Percutaneous coronary intervention (PCI) is commonly used to alleviate stable angina symptoms.Uncertainty exists regarding whether PCI
Study: STRONG-HF trial examined rapid up-titration of heart failure medications (GDMT) after hospitalization.Goal: Reach optimal GDMT doses within 2 weeks after discharge.Findings:Over 90% of patients achieved medium-to-high GDMT doses withi
Key Points from "Treat to Target or With Intensity? Both Statin Tactics Cut MACE: LODESTAR":The study compares two strategies for managing LDL cholesterol in coronary artery disease (CAD):Treat-to-target: aiming for LDL levels between 50-70 m
Key Points of the Study:T-TEER with the TriClip device significantly improved health status in patients with severe tricuspid regurgitation (TR) compared to medical therapy alone.This improvement was seen in both the short-term (1 month) and
Key Points from PROMISE 2 Trial:• Problem: 20% of CLTI patients have no revascularization options, leading to amputations.• Solution: Transcatheter arterialization of deep veins creates an artery-to-vein connection, delivering oxygenated bloo
Key Points from this trial:The CLASP IID trial, the first randomized controlled trial comparing the PASCAL system and the MitraClip system in prohibitive-risk patients with significant symptomatic degenerative mitral regurgitation (DMR), aime
Key points of the DANPACE II study on atrial pacing and atrial fibrillation in sinus node dysfunction:1. Minimizing atrial pacing in pacemakers doesn't prevent atrial fibrillation (AF):• 46% of patients regardless of pacing rate (40bpm or 60b
Major Trends:Independent Medical Board: Cardiologists seek a new board separate from the ABIM due to concerns with MOC requirements.Scope of Practice Debates: Tensions arise over advanced nurse practitioners performing complex procedures l
Key Points of Coronary Artery Disease Studies in 2023:• ORBITA-2: Confirmed PCI's role in relieving angina symptoms for stable patients.• SELECT: Semaglutide (Ozempic) reduced cardiovascular events in overweight/obese patients with existing C
A quick rundown of the key developments:Trials:STEP-HFpEFCASTLE-HTxHEART FIDDAPA-MIPolicy and Guidelines:ESC cardiomyopathy guidelinesInflation Reduction ActFDA approvals: dapagliflozin and sotagliflozinOther Highlight
Focus on Valves:TAVI vs. SAVR: Long-term data showed mixed results. PARTNER 3 (Sapien 3 valve) benefits declined over time, while Evolut Low Risk (CoreValve, Evolut R/PRO) favoured TAVI. Experts advise caution in direct comparison.Aortic R
Key Highlights:Lodoco is the first anti-inflammatory approved for reducing cardiovascular events in ASCVD patients.Bempedoic acid offers an alternative for high-risk patients who can't tolerate statins.Semaglutide has emerged as a powerf
Key Points of Endovascular Procedures and Devices in 2023:FDA Actions:Lifted restrictions on paclitaxel-coated balloons and stents for PAD after updated data showed no increased mortality risk.Approved coverage of carotid artery stenting
Heart Rhythm 2023: Innovations in Ablation, Devices, and Conduction System Pacing.Catheter Ablation and LAAO Advance:CASTLE-HTx: Ablation for AF proved beneficial in patients with advanced heart failure, potentially paving the way for wide
Key Points:Multi-vessel coronary disease (MVD) in acute myocardial infarction (AMI) is still a difficult condition to manage.Complete revascularization improves outcomes for hemodynamically stable patients without any safety concerns.A p
Key findings of the FRAIL-AF trial: * Switching from vitamin K antagonist (VKA) to non-vitamin K antagonist oral anticoagulant (NOAC) therapy was associated with an increased risk of major and clinically relevant bleeding (hazard ratio [HR] 1
Summary of the STEP-HFpEF trial 2023 published in Nature MedicineThe STEP-HFpEF trial was a study of semaglutide in patients with obesity phenotype of heart failure and preserved ejection fraction (HFpEF).Semaglutide improved symptoms, phy
Key points of the FIRE trial: The study was a randomized trial of complete revascularization vs. culprit-only revascularization in older patients (≥75 years of age) with myocardial infarction and multi-vessel disease.A total of 1445 patie
These are the key points from this 2023 ACC/AHA guideline in managing chronic coronary disease. Patients with chronic coronary disease should receive care from a team of healthcare professionals (Team-based, patient-centered care)All pati
The ATTRibute-CM trial was a randomized, double-blind, placebo-controlled trial that evaluated the efficacy and safety of acoramidis in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). The trial enrolled 632 patients with symptomat
Key Points from ARREST trial findings:The study included 862 patients who were resuscitated after a cardiac arrest.The patients were randomly assigned to be taken to either a well-resourced cardiac arrest center or the nearest emergency de
Here is a summary of the key points from the 2023 ESC guidelines for the management of endocarditis:Prevention: People at high risk of endocarditis should take steps to prevent it, such as taking antibiotics before dental procedures.Diagno
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